Lak Shin Jeong

Overview

Best Publications

• Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

  R F Schinazi;C K Chu;A Peck;A McMillan

  409
  Citations

• Deoxycytidine deaminase-resistant stereoisomer is the active form of (+/-)-2',3'-dideoxy-3'-thiacytidine in the inhibition of hepatitis B virus replication.

  C.N. Chang;S.L. Doong;J.H. Zhou;J.W. Beach

  355
  Citations

• Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

  J. Warren Beach;Lak S. Jeong;Antonio J. Alves;Douglas Pohl

  291
  Citations

• Asymmetric synthesis and biological evaluation of beta-L-(2R,5S)- and alpha-L-(2R,5R)-1,3-oxathiolane-pyrimidine and -purine nucleosides as potential anti-HIV agents.

  L. S. Jeong;R. F. Schinazi;J. W. Beach;H. O. Kim

  232
  Citations

• Overactivated Neddylation Pathway as a Therapeutic Target in Lung Cancer

  Lihui Li;Mingsong Wang;Guangyang Yu;Ping Chen;Ping Chen

  203
  Citations

• c-Cbl-Mediated Neddylation Antagonizes Ubiquitination and Degradation of the TGF-β Type II Receptor

  Wei Zuo;Fei Huang;Y. Jeffrey Chiang;Meng Li

  171
  Citations

• L-.beta.-(2S,4S)- and L-.alpha.-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships

  H. O. Kim;R. F. Schinazi;Kirupathevy Shanmuganathan;L. S. Jeong

  166
  Citations

• Improved and alternative synthesis of d- and l-cyclopentenone derivatives, the versatile intermediates for the synthesis of carbocyclic nucleosides

  Hyung Ryong Moon;Won Jun Choi;Hea Ok Kim;Lak Shin Jeong

  143
  Citations

• Potent anti-HIV and anti-HBV activities of (−)-L-β-dioxolane-C and (+)-L-β-dioxolane-T and their asymmetric syntheses.

  Hea O. Kim;Kirupathevy Shanmuganathan;Antonio J. Alves;Lak S. Jeong

  140
  Citations

• Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.

  Lak Shin Jeong;Seung Ah Choe;Prashantha Gunaga;Hea Ok Kim

  133
  Citations

• Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics

  Dnyandev B Jarhad;Karishma K Mashelkar;Hong-Rae Kim;Minsoo Noh

  132
  Citations

• A highly stereoselective synthesis of anti-HIV 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxynucleosides

  J. Warren Beach;Hea O. Kim;Lak S. Jeong;Satyanarayana Nampalli

  117
  Citations

• Enantiomeric synthesis of (+)-BCH-189 [(+)-(2S,5R)-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine] from D-mannose and its anti-HIV activity

  Chung K. Chu;J. Warren Beach;Lak S. Jeong;Bo G. Choi

  116
  Citations

• N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.

  Lak Shin Jeong;Dong Zhe Jin;Hea Ok Kim;Dae Hong Shin

  111
  Citations

• Structure-activity relationships of .beta.-D-(2S,5R)- and .alpha.-D-(2S,5S)-1,3-oxathiolanyl nucleosides as potential anti-HIV agents

  L. S. Jeong;R. F. Schinazi;J. W. Beach;H. O. Kim

  109
  Citations

• Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity.

  Won Jun Choi;Hyung Ryong Moon;Hea Ok Kim;Byul Nae Yoo

  107
  Citations

• Design, Synthesis, and Biological Evaluation of Fluoroneplanocin A as the Novel Mechanism-Based Inhibitor of S-Adenosylhomocysteine Hydrolase

  Lak Shin Jeong;Su Jeong Yoo;Kang Man Lee;Mi Jeong Koo

  103
  Citations

• Recent Advances in the Synthesis of the Carbocyclic Nucleosides as Potential Antiviral Agents

  Lak Shin Jeong;Jeong A Lee

  98
  Citations

• Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.

  Lak Shin Jeong;Hyuk Woo Lee;Kenneth A. Jacobson;Hea Ok Kim

  94
  Citations

• Syntheses of D- and L-cyclopentenone derivatives using ring-closing metathesis: versatile intermediates for the synthesis of D- and L-carbocyclic nucleosides.

  Won Jun Choi;Jae Gyu Park;Su Jeong Yoo;Hea Ok Kim

  93
  Citations

• Asymmetric synthesis of enantiomerically pure (−)-(1′R,4′R)-dioxolane-thymine and its anti-HIV activity.

  Chung K. Chu;Soon K. Ahn;H.O. Kim;J.Warren Beach

  89
  Citations

• A highly stereoselective glycosylation of 2-(phenylselenenyl)-2,3-dideoxyribose derivative with thymine: synthesis of 3'-deoxy-2',3'-didehydrothymidine and 3'-deoxythymidine

  Chung K. Chu;J. Ramesh Babu;J. Warren Beach;Soon K. Ahn

  88
  Citations