World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
68
Citations
16199
World Ranking
7803
National Ranking
69

Overview

Sang Kook Lee is affiliated with Seoul National University in South Korea. Their research spans multiple disciplines within the biomedical and chemical sciences, focusing largely on the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine.

Their scientific contributions cover several subfields including Molecular Biology, Pharmacology, Organic Chemistry, Biotechnology, and Oncology. Lee's work encompasses a diverse range of topics, with significant focus on Microbial Natural Products and Biosynthesis, Marine Sponges and Natural Products, Cancer Mechanisms and Therapy, Genomics and Phylogenetic Studies, Ubiquitin and proteasome pathways, Bioactive Compounds and Antitumor Agents, and Microtubule and mitosis dynamics.

The scientist has published extensively in a range of journals, with frequent publications in:

  • Journal of Natural Products
  • Marine Drugs
  • Pharmaceuticals
  • The Cambridge Structural Database
  • Angewandte Chemie International Edition

Lee's recent papers include the following:

  • Catalytic and Enantioselective Control of the C-N Stereogenic Axis via the Pictet-Spengler Reaction, 2021, Angewandte Chemie International Edition
  • Terminalia chebula Retz. extract ameliorates the symptoms of atopic dermatitis by regulating anti-inflammatory factors in vivo and suppressing STAT1/3 and NF-ĸB signaling in vitro, 2022, Phytomedicine
  • Discovery and Biosynthesis of Cihunamides, Macrocyclic Antibacterial RiPPs with a Unique C−N Linkage Formed by CYP450 Catalysis, 2023, Angewandte Chemie International Edition
  • Antitumor Activity of Ohmyungsamycin A through the Regulation of the Skp2-p27 Axis and MCM4 in Human Colorectal Cancer Cells, 2020, Journal of Natural Products
  • Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms, 2020, Science Advances

The scientist collaborates frequently with several coauthors, prominently including:

  • Dong-Chan Oh
  • Eun Seo Bae
  • Woong Sub Byun
  • Yeo Joon Yoon
  • Suckchang Hong

Best Publications

  • Evaluation of the antioxidant potential of natural products.

    S K Lee;Z H Mbwambo;H Chung;L Luyengi

  • Circular RNAs in Cancer

    Duc Hiep Bach;Sang Kook Lee;Anil K. Sood

  • Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells.

    Chae Hee Hong;Sun Kyung Hur;O-Jin Oh;Sun Sook Kim

  • Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells

    Sun Suk Kim;O-Jin Oh;Hye-Young Min;Eun-Jung Park

  • The role of exosomes and miRNAs in drug-resistance of cancer cells.

    Duc-Hiep Bach;Ji-Young Hong;Hyen Joo Park;Sang Kook Lee

  • Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta[b]benzofuran lignans isolated from Aglaia elliptica.

    Sang Kook Lee;Baoliang Cui;Rajeshwari R Mehta;A.Douglas Kinghorn

  • The Dual Role of Bone Morphogenetic Proteins in Cancer

    Duc-Hiep Bach;Hyen Joo Park;Sang Kook Lee

  • Antioxidant flavonoid glycosides from Daphniphyllum calycinum

    E. J. C. Gamez;L. Luyengi;S. K. Lee;L.-F. Zhu

  • Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities

    Myoung Ju Moon;Sang Kook Lee;Jong-Won Lee;Woo Keun Song

  • Biologic evaluation of curcumin and structural derivatives in cancer chemoprevention model systems

    Stefan Gafner;Sang-Kook Lee;Muriel Cuendet;Sophie Barthélémy

  • Flavonoid constituents of Chorizanthe diffusa with potential cancer chemopreventive activity.

    Chung Hs;Chang Lc;Lee Sk;Shamon La

  • Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase.

    C Gerhäuser;W Mar;W Mar;S K Lee;N Suh

  • Long noncoding RNAs in cancer cells.

    Duc-Hiep Bach;Sang Kook Lee

  • Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells

    In-Kyung Bae;Hye-Young Min;Ah-Reum Han;Eun-Kyoung Seo

  • Cancer Chemopreventive Activity Mediated by 4′-Bromoflavone, a Potent Inducer of Phase II Detoxification Enzymes

    Lynda L. Song;Jerome W. Kosmeder;Sang Kook Lee;Clarissa Gerhäuser

  • Activity-guided isolation of antioxidative constituents of Cotinus coggygria.

    H. E. Westenburg;K. J. Lee;S. K. Lee;H. H S Fong

  • Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-activated protein kinases and/or the nuclear factor-κB

    Won Yoon Chung;Jae Hee Park;Mi Jeong Kim;Heui Ok Kim

  • Ultrasonication-assisted extraction of resveratrol from grapes

    Yong-Jin Cho;Ji-Young Hong;Hyang Sook Chun;Sang Kook Lee

  • Solid phase combinatorial synthesis of benzothiazoles and evaluation of topoisomerase II inhibitory activity

    Suk June Choi;Hyen Joo Park;Sang Kook Lee;Sang Woong Kim

  • Isolation and Characterization of Flaxseed (Linum usitatissimum) Constituents

    Sheng-Xiang Qiu;Zhi-Zhen Lu;Lumonadio Luyengi;Sang Kook Lee

Frequent Co-Authors

Lak Shin Jeong
Lak Shin Jeong Seoul National University
Sanghee Kim
Sanghee Kim Seoul National University
John M. Pezzuto
John M. Pezzuto Western New England University
Yeong Shik Kim
Yeong Shik Kim Seoul National University
Sam Sik Kang
Sam Sik Kang Seoul National University
Yong Chul Kim
Yong Chul Kim Gwangju Institute of Science and Technology
A. Douglas Kinghorn
A. Douglas Kinghorn The Ohio State University
Jae-Kwan Hwang
Jae-Kwan Hwang Yonsei University
KiHwan Bae
KiHwan Bae Chungnam National University
Kenneth A. Jacobson
Kenneth A. Jacobson National Institutes of Health

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