The scientist’s investigation covers issues in Cancer research, Cell biology, Androgen receptor, KDM1A and Molecular biology. His Cancer research study integrates concerns from other disciplines, such as Histone H3, Histone, Demethylase, Coactivator and Nuclear receptor. His studies deal with areas such as Syndecan 1, Cadherin, Retinoic acid receptor alpha, Retinoid X receptor and Retinoid X receptor alpha as well as Cell biology.
His biological study focuses on RNF4. The KDM1A study combines topics in areas such as Progenitor cell, Stem cell and Myeloid leukemia, Immunology. His research integrates issues of Cranial neural crest and Regulation of gene expression in his study of Molecular biology.
His main research concerns Cancer research, Cell biology, Demethylase, Biochemistry and Molecular biology. The concepts of his Cancer research study are interwoven with issues in Prostate cancer, Androgen receptor, FHL2 and Epigenetics. His Androgen receptor research includes themes of Coactivator and Nuclear receptor.
His Cell biology course of study focuses on Histone code and Histone demethylation. Roland Schüle has researched Demethylase in several fields, including Histone H3, Histone methyltransferase and Histone methylation. His Molecular biology research is multidisciplinary, incorporating perspectives in Enhancer, Histone acetyltransferase, Transcription factor, Transactivation and Promoter.
His scientific interests lie mostly in Epigenetics, Cancer research, Cell biology, Regulation of gene expression and Cell cycle. The various areas that Roland Schüle examines in his Epigenetics study include Cancer, Receptor and Pharmacology. His research in Cancer research intersects with topics in Cytotoxic T cell and Breast cancer.
His Epidermis study in the realm of Cell biology interacts with subjects such as GLIS1. His study on Regulation of gene expression also encompasses disciplines like
The scientist’s investigation covers issues in Regulation of gene expression, Cell biology, Chromatin, Methylation and Transcription factor. His Regulation of gene expression research is multidisciplinary, incorporating elements of Myeloid and Cancer research. The Stem cell research he does as part of his general Cell biology study is frequently linked to other disciplines of science, such as GLIS1, therefore creating a link between diverse domains of science.
His study in Histone code and Histone lysine methylation are all subfields of Chromatin. The study incorporates disciplines such as Histone H4, Cell cycle, Prostate cancer and Effector in addition to Methylation. His Transcription factor study combines topics in areas such as Leukemia, Myeloid leukemia, Epigenetics and Cellular differentiation.
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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.
Eric Metzger;Melanie Wissmann;Na Yin;Judith M. Müller.
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.
Melanie Wissmann;Na Yin;Judith M. Müller;Holger Greschik.
Nature Cell Biology (2007)
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology
Soyoung Lim;Andreas Janzer;Astrid Becker;Andreas Zimmer.
FHL2, a Novel Tissue-Specific Coactivator of the Androgen Receptor
Judith M. Müller;Ulrike Isele;Eric Metzger;Annette Rempel.
The EMBO Journal (2000)
Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy
Johannes H. Schulte;Soyoung Lim;Alexander Schramm;Nicolaus Friedrichs.
Cancer Research (2009)
Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence.
Philip Kahl;Lucia Gullotti;Lukas Carl Heukamp;Susanne Wolf.
Cancer Research (2006)
A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing
Yue Zhao;Guillaume Lang;Saya Ito;Jacques Bonnet.
Molecular Cell (2008)
Phosphorylation of histone H3T6 by PKCβ I controls demethylation at histone H3K4
Eric Metzger;Axel Imhof;Dharmeshkumar Patel;Philip Kahl.
Cloning and characterization of a fourth human somatostatin receptor.
Lucia Rohrer;Friedrich Raulf;Christian Bruns;Reinhard Buettner.
Proceedings of the National Academy of Sciences of the United States of America (1993)
All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.
Catherine Stehlin-Gaon;Dominica Willmann;Denis Zeyer;Sarah Sanglier.
Nature Structural & Molecular Biology (2003)
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