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Biology and Biochemistry

D-Index
65
Citations
17448
World Ranking
9059
National Ranking
656

Overview

Roland Schüle is affiliated with the University of Freiburg in Germany and focuses their research on molecular biology and medicine, particularly investigating epigenetics, cancer-related gene regulation, and enzymatic pathways relevant to oncology and metabolic regulation.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these, their subfields of concentration are:

  • Molecular Biology
  • Surgery
  • Oncology
  • Immunology
  • Genetics

Roland Schüle's research topics cover a range of biological and pathological processes, including:

  • Epigenetics and DNA Methylation
  • Cancer-related gene regulation
  • Bladder and Urothelial Cancer Treatments
  • Peptidase Inhibition and Analysis
  • Ubiquitin and proteasome pathways
  • Sirtuins and Resveratrol in Medicine
  • Urinary and Genital Oncology Studies

Frequent co-authors collaborating with Schüle are:

  • Eric Metzger
  • Manfred Jung
  • Manuela Sum
  • Holger Greschik
  • Oliver Einsle

Their work has been published primarily in journals such as:

  • Journal of Medicinal Chemistry
  • International Journal of Molecular Sciences
  • Osteoarthritis and Cartilage
  • Carcinogenesis
  • Cancer Cell International

Selected recent papers include:

  • Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death, 2020, Cancer Cell International
  • Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases, 2021, Carcinogenesis
  • Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration, 2022, RSC Chemical Biology
  • Nutrient regulation of the islet epigenome controls adaptive insulin secretion, 2023, Journal of Clinical Investigation
  • Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells, 2020, ChemBioChem

Best Publications

  • LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.

    Eric Metzger;Melanie Wissmann;Na Yin;Judith M. Müller

  • Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor

    Roland Schüle;Pundl Rangarajan;Steven A Kliewer;Lynn J. Ransone

  • Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

    Roland Schüle;Kazuhiko Umesono;David J. Mangelsdorf;Jack Bolado

  • Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression.

    Melanie Wissmann;Na Yin;Judith M. Müller;Holger Greschik

  • Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

    Soyoung Lim;Andreas Janzer;Astrid Becker;Andreas Zimmer

  • Lysine-Specific Demethylase 1 Is Strongly Expressed in Poorly Differentiated Neuroblastoma: Implications for Therapy

    Johannes H. Schulte;Soyoung Lim;Alexander Schramm;Nicolaus Friedrichs

  • Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence.

    Philip Kahl;Lucia Gullotti;Lukas Carl Heukamp;Susanne Wolf

  • FHL2, a Novel Tissue-Specific Coactivator of the Androgen Receptor

    Judith M. Müller;Ulrike Isele;Eric Metzger;Annette Rempel

  • A TFTC/STAGA Module Mediates Histone H2A and H2B Deubiquitination, Coactivates Nuclear Receptors, and Counteracts Heterochromatin Silencing

    Yue Zhao;Guillaume Lang;Saya Ito;Jacques Bonnet

  • All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta.

    Catherine Stehlin-Gaon;Dominica Willmann;Denis Zeyer;Sarah Sanglier

  • Cloning and characterization of a fourth human somatostatin receptor.

    Lucia Rohrer;Friedrich Raulf;Christian Bruns;Reinhard Buettner

  • Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.

    Eric Metzger;Na Yin;Melanie Wissmann;Natalia Kunowska

  • The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus

    Judith M. Müller;Eric Metzger;Holger Greschik;Anja-Katrin Bosserhoff

  • FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/β-catenin signaling-dependent Runx2 expression

    Zahia Hamidouche;Eric Haÿ;Pascal Vaudin;Pierre Charbord

  • Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation.

    A Sprüssel;J H Schulte;S Weber;M Necke

  • The SRF Target Gene Fhl2 Antagonizes RhoA/MAL-Dependent Activation of SRF

    Ulrike Philippar;Gerhard Schratt;Christoph Dieterich;Judith M. Müller

  • Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern.

    Stefan Bagheri-Fam;Francisco Barrionuevo;Ulrike Dohrmann;Thomas Günther

  • Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism.

    Sherif A. Ibrahim;George W. Yip;Christian Stock;Jun-Wei Pan

  • Extracellular Signal-Regulated Kinase 2 Interacts with and Is Negatively Regulated by the LIM-Only Protein FHL2 in Cardiomyocytes

    Nicole H. Purcell;Dina Darwis;Orlando F. Bueno;Judith M. Müller

  • Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation

    Eric Metzger;Na Yin;Melanie Wissmann;Natalia Kunowska

Frequent Co-Authors

Manfred Jung
Manfred Jung University of Freiburg
Wolfgang Sippl
Wolfgang Sippl Martin Luther University Halle-Wittenberg
Michael Lübbert
Michael Lübbert University of Freiburg
Hubert Serve
Hubert Serve Goethe University Frankfurt
Axel Imhof
Axel Imhof Ludwig-Maximilians-Universität München
Emmanuel Barillot
Emmanuel Barillot Institute Curie
Oleg Fedorov
Oleg Fedorov University of Oxford
Udo Oppermann
Udo Oppermann University of Oxford
Simone Fulda
Simone Fulda Goethe University Frankfurt
Edith Heard
Edith Heard Collège de France

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