What is he best known for?
The fields of study he is best known for:
Wolfgang Sippl mainly focuses on Biochemistry, Histone, Docking, NAD+ kinase and Histone deacetylase.
His is involved in several facets of Biochemistry study, as is seen by his studies on Sirtuin, Enzyme, SIRT2, Methyltransferase and Enzyme inhibitor.
The study incorporates disciplines such as Cell cycle, Epigenetics and Lysine in addition to Histone.
Docking is a subfield of Stereochemistry that he explores.
He has included themes like Homology modeling and G protein-coupled receptor in his Stereochemistry study.
As a part of the same scientific family, Wolfgang Sippl mostly works in the field of Nicotinamide adenine dinucleotide, focusing on Histone deacetylase 5 and, on occasion, HDAC8 and Histone Demethylases.
His most cited work include:
- Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT (265 citations)
- Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells (234 citations)
- Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme (181 citations)
What are the main themes of his work throughout his whole career to date?
Wolfgang Sippl spends much of his time researching Biochemistry, Docking, Stereochemistry, Drug discovery and Histone.
Enzyme, NAD+ kinase, Sirtuin, Kinase and SIRT2 are the subjects of his Biochemistry studies.
Wolfgang Sippl combines subjects such as Quantitative structure–activity relationship, In vitro, Structure–activity relationship and HDAC8 with his study of Docking.
His Stereochemistry research incorporates themes from Receptor and Binding site.
His studies deal with areas such as Medicinal plants and Traditional medicine as well as Drug discovery.
Computational biology is closely connected to Epigenetics in his research, which is encompassed under the umbrella topic of Histone.
He most often published in these fields:
- Biochemistry (34.75%)
- Docking (27.87%)
- Stereochemistry (18.03%)
What were the highlights of his more recent work (between 2018-2021)?
- Docking (27.87%)
- Computational biology (12.13%)
- Drug discovery (14.10%)
In recent papers he was focusing on the following fields of study:
His main research concerns Docking, Computational biology, Drug discovery, Biochemistry and Stereochemistry.
His Docking study combines topics in areas such as Apocynaceae, Voacanga africana, Alkaloid, Enzyme and HDAC8.
His studies deal with areas such as Binding free energy, Molecular model, Pharmacophore, In silico and Epigenetics as well as Computational biology.
The concepts of his Drug discovery study are interwoven with issues in Histone deacetylase, Natural product and Medicinal plants.
His work on Lysine, Butyrylcholinesterase and Small molecule as part of his general Biochemistry study is frequently connected to Monoamine oxidase B and Urolithin, thereby bridging the divide between different branches of science.
Wolfgang Sippl interconnects Tertiary amine, Biological activity and Bacteria in the investigation of issues within Stereochemistry.
Between 2018 and 2021, his most popular works were:
- Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors (37 citations)
- Computational Drug Repurposing: Current Trends. (24 citations)
- Proteolysis targeting chimeras (PROTACs) for epigenetics research. (17 citations)
In his most recent research, the most cited papers focused on:
His primary scientific interests are in Drug discovery, Computational biology, Biochemistry, Cancer research and Docking.
His Drug discovery research is multidisciplinary, incorporating perspectives in Natural product and Class iii.
His Computational biology research incorporates themes from Sirtuin, Protein degradation, Proteolysis and Proteasome.
Wolfgang Sippl conducted interdisciplinary study in his works that combined Biochemistry and Side chain.
His Cancer research research includes themes of Virtual screening, In vitro, Growth inhibition, Histone and Regulation of gene expression.
His Docking research is multidisciplinary, relying on both Acetylation, Phenothiazine, HDAC1, HDAC4 and HDAC6.
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