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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15662
World Ranking
6420
National Ranking
453

Overview

Wolfgang Sippl is affiliated with Martin Luther University Halle-Wittenberg in Germany. Their research output is situated primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

Their subfields of study include Molecular Biology, Organic Chemistry, Oncology, Pharmacology, and Geriatrics and Gerontology.

Sippl's main research topics cover areas such as Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Peptidase Inhibition and Analysis, Sirtuins and Resveratrol in Medicine, Ubiquitin and proteasome pathways, Epigenetics and DNA Methylation, and Computational Drug Discovery Methods.

The scientist has contributed several papers including:

  • "Strategies To Design Selective Histone Deacetylase Inhibitors," 2021, ChemMedChem
  • "Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target," 2022, Nature Chemical Biology
  • "The potential of anti-malarial compounds derived from African medicinal plants: a review of pharmacological evaluations from 2013 to 2019," 2020, Malaria Journal
  • "Proteolysis targeting chimeras (PROTACs) for epigenetics research," 2020, Current Opinion in Chemical Biology
  • "Pharmacoinformatic Investigation of Medicinal Plants from East Africa," 2020, Molecular Informatics

The scientist has frequently published in journals such as:

  • Journal of Medicinal Chemistry
  • International Journal of Molecular Sciences
  • European Journal of Medicinal Chemistry
  • Archiv der Pharmazie
  • Molecules

Wolfgang Sippl has collaborated notably with co-authors including Dina Robaa, Mike Schutkowski, Manfred Jung, Matthias Schmidt, and Matthes Zessin. These collaborations involve multiple joint publications, with the highest counts reaching 35 coauthored papers per collaborator.

Best Publications

  • Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

    Patrice Dubreuil;Sébastien Letard;Marco Ciufolini;Laurent Gros

  • Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

    Frédéric Colland;Etienne Formstecher;Xavier Jacq;Céline Reverdy

  • Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

    Tobias Rumpf;Matthias Schiedel;Berin Karaman;Claudia Roessler

  • Discovery of Specific Inhibitors of Human USP7/HAUSP Deubiquitinating Enzyme

    Céline Reverdy;Susan Conrath;Roman Lopez;Cécile Planquette

  • HDAC8: a multifaceted target for therapeutic interventions

    Alokta Chakrabarti;Ina Oehme;Olaf Witt;Guilherme Oliveira

  • Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

    Matthias Schiedel;Daniel Herp;Sören Hammelmann;Sören Swyter

  • AfroDb: A Select Highly Potent and Diverse Natural Product Library from African Medicinal Plants

    Fidele Ntie-Kang;Denis Zofou;Smith B. Babiaka;Rolande Meudom

  • Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)

    Johannes Trapp;Rene Meier;Darunee Hongwiset;Matthias U. Kassack

  • Activation, regulation, and inhibition of DYRK1A.

    Walter Becker;Wolfgang Sippl

  • The potential of anti-malarial compounds derived from African medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids.

    Fidele Ntie-Kang;Fidele Ntie-Kang;Pascal Amoa Onguéné;Lydia L Lifongo;Jean Claude Ndom

  • Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

    Johannes Trapp;Anne Jochum;Rene Meier;Laura Saunders

  • Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.

    Robert C. Neugebauer;Urszula Uchiechowska;Rene Meier;Henning Hruby

  • The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors

    Astrid Spannhoff;Alexander-Thomas Hauser;Ralf Heinke;Wolfgang Sippl

  • Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.

    Martin Marek;Srinivasaraghavan Kannan;Alexander-Thomas Hauser;Marina de Moraes Mourão

  • Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases

    Astrid Spannhoff;Ralf Heinke;Ingo Bauer;Patrick Trojer

  • Receptor-based 3D QSAR analysis of estrogen receptor ligands - merging the accuracy of receptor-based alignments with the computational efficiency of ligand-based methods

    Wolfgang Sippl

  • Regulation of G2/M Transition by Inhibition of WEE1 and PKMYT1 Kinases.

    Matthias Schmidt;Alexander Rohe;Charlott Platzer;Abdulkarim Najjar

  • Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

    J M Gajer;S D Furdas;A Gründer;M Gothwal

  • Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.

    Jean-Marie Contreras;Isabelle Parrot;Wolfgang Sippl;Yveline M. Rival

  • Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors.

    Wolfgang Sippl;Jean-Marie Contreras;Isabelle Parrot;Yveline M. Rival

Frequent Co-Authors

Manfred Jung
Manfred Jung University of Freiburg
Raymond J. Pierce
Raymond J. Pierce University of Lille
Roland Schüle
Roland Schüle University of Freiburg
Oliver Einsle
Oliver Einsle University of Freiburg
Judit Ovádi
Judit Ovádi Hungarian Academy of Sciences
Paavo Honkakoski
Paavo Honkakoski University of Eastern Finland
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Mike Schutkowski
Mike Schutkowski Martin Luther University Halle-Wittenberg
Arasu Ganesan
Arasu Ganesan University of East Anglia
Sergio Verjovski-Almeida
Sergio Verjovski-Almeida Universidade de São Paulo

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