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Chemistry

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48
Citations
7088
World Ranking
15382
National Ranking
549

Biology and Biochemistry

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56
Citations
9627
World Ranking
14587
National Ranking
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Overview

Dante Rotili is affiliated with Sapienza University of Rome in Italy, contributing extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research encompasses a wide range of topics, with a notable focus on molecular biology and several subfields including epidemiology, geriatrics and gerontology, oncology, and cancer research.

The main topics of their work include:

  • Sirtuins and Resveratrol in Medicine
  • Histone Deacetylase Inhibitors Research
  • Autophagy in Disease and Therapy
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Calcium signaling and nucleotide metabolism
  • PARP inhibition in cancer therapy

Some of the recent papers authored or co-authored by Dante Rotili are:

  • GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design (2023), published in Green Chemistry
  • Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression (2021), published in Gastroenterology
  • Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer (2020), published in Frontiers in Oncology
  • Emerging Therapeutic Potential of SIRT6 Modulators (2021), published in Journal of Medicinal Chemistry
  • The Two-Faced Role of SIRT6 in Cancer (2021), published in Cancers

Dante Rotili collaborates frequently with several researchers, including:

  • Antonello Mai
  • Francesco Fiorentino
  • Sérgio Valente
  • Emanuele Fabbrizi
  • Rossella Fioravanti

Their publications are frequently found in the following venues:

  • Journal of Medicinal Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • ChemMedChem
  • Cells
  • European Journal of Medicinal Chemistry

Best Publications

  • Histone deacetylation in epigenetics: An attractive target for anticancer therapy

    Antonello Mai;Silvio Massa;Dante Rotili;Ilaria Cerbara

  • Correction: Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma

    Sonia Coni;Anna Barbara Mancuso;Laura Di Magno;Giulia Sdruscia

  • Sirtuin functions and modulation: from chemistry to the clinic.

    Vincenzo Carafa;Dante Rotili;Mariantonietta Forgione;Mariantonietta Forgione;Francesca Cuomo

  • SIRT5 regulation of ammonia-induced autophagy and mitophagy

    Lucia Polletta;Enza Vernucci;Ilaria Carnevale;Tania Arcangeli

  • Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect

    E Lara;A Mai;V Calvanese;L Altucci

  • Inhibition of Class I Histone Deacetylases Unveils a Mitochondrial Signature and Enhances Oxidative Metabolism in Skeletal Muscle and Adipose Tissue

    Andrea Galmozzi;Nico Mitro;Alessandra Ferrari;Elise Gers

  • Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

    Antonello Mai;Silvio Massa;Riccardo Pezzi;Silvia Simeoni

  • Targeting Histone Demethylases A New Avenue for the Fight against Cancer

    Dante Rotili;Antonello Mai

  • Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC–MEF2 complexes

    Angela Nebbioso;Fabio Manzo;Marco Miceli;Mariarosaria Conte

  • Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

    Weijie You;Dante Rotili;Tie-Mei Li;Tie-Mei Li;Christian Kambach

  • Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties.

    Antonello Mai;Dante Rotili;Domenico Tarantino;Prisca Ornaghi

  • "Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.

    Andrea Savarino;Antonello Mai;Sandro Norelli;Sary El Daker

  • Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities

    Dante Rotili;Stefano Tomassi;Mariarosaria Conte;Rosaria Benedetti

  • GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design

    Unknown

  • Nitric Oxide Modulates Chromatin Folding in Human Endothelial Cells via Protein Phosphatase 2A Activation and Class II Histone Deacetylases Nuclear Shuttling

    Barbara Illi;Claudio Dello Russo;Claudia Colussi;Jessica Rosati

  • Development of 1,2,4-Oxadiazoles as Potent and Selective Inhibitors of the Human Deacetylase Sirtuin 2: Structure–Activity Relationship, X-ray Crystal Structure, and Anticancer Activity

    Sébastien Moniot;Mariantonietta Forgione;Mariantonietta Forgione;Alessia Lucidi;Gebremedhin S. Hailu

  • Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

    Gianluca Sbardella;Sabrina Castellano;Caterina Vicidomini;Dante Rotili

  • Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells.

    Sara Iachettini;Daniela Trisciuoglio;Dante Rotili;Alessia Lucidi

  • Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.

    Antonello Mai;Dante Rotili;Silvio Massa;Gerald Brosch

  • Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.

    Tuo Hu;Tuo Hu;Surendra K. Shukla;Enza Vernucci;Chunbo He

  • Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives

    Gebremedhin S. Hailu;Dina Robaa;Mariantonietta Forgione;Mariantonietta Forgione;Wolfgang Sippl

  • p300/CBP-Associated Factor Selectively Regulates the Extinction of Conditioned Fear

    Wei Wei;Carlos M. Coelho;Xiang Li;Roger Marek

Frequent Co-Authors

Antonello Mai
Antonello Mai Sapienza University of Rome
Lucia Altucci
Lucia Altucci University of Campania "Luigi Vanvitelli"
Sergio Valente
Sergio Valente Sapienza University of Rome
José A. Esté
José A. Esté Autonomous University of Barcelona
Marino Artico
Marino Artico Sapienza University of Rome
Gerald Brosch
Gerald Brosch Innsbruck Medical University
Clemens Steegborn
Clemens Steegborn University of Bayreuth
Giovanni Maga
Giovanni Maga National Research Council (CNR)
Carlo Gaetano
Carlo Gaetano Goethe University Frankfurt
Iole Venditti
Iole Venditti Roma Tre University

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