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Clemens Steegborn

Clemens Steegborn

D-Index & Metrics

Biology and Biochemistry

D-Index
70
Citations
22502
World Ranking
6902
National Ranking
501

Overview

Clemens Steegborn is affiliated with the University of Bayreuth in Germany. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a focused expertise in Molecular Biology, Geriatrics and Gerontology, Epidemiology, Oncology, and Physiology.

The main topics covered in their body of work include:

  • Sirtuins and Resveratrol in Medicine
  • Autophagy in Disease and Therapy
  • PARP inhibition in cancer therapy
  • Cancer, Hypoxia, and Metabolism
  • Monoclonal and Polyclonal Antibodies Research
  • Sperm and Testicular Function
  • Glycosylation and Glycoproteins Research

Steegborn has published research in several scientific journals, often contributing multiple publications to a few key venues. Frequent publication outlets for their work include:

  • Journal of Medicinal Chemistry
  • International Journal of Molecular Sciences
  • ACS Medicinal Chemistry Letters
  • Angewandte Chemie International Edition
  • Frontiers in Physiology

Their recent scientific papers cover a range of subjects within molecular biology and medical research. Notable recent publications include:

  • Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression, 2021, Gastroenterology
  • Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer, 2020, Frontiers in Oncology
  • On-demand male contraception via acute inhibition of soluble adenylyl cyclase, 2023, Nature Communications
  • Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance, 2021, Angewandte Chemie International Edition
  • Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5, 2022, Journal of Medicinal Chemistry

The scientist frequently collaborates with a select group of co-authors, suggesting a close network of research partners. These collaborators include Jochen Buck, Lonny R. Levin, Michael Weyand, Jacob Ferreira, and Peter T. Meinke, each having contributed to multiple publications alongside Steegborn.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

    Christine Schlicker;Melanie Gertz;Panagiotis Papatheodorou;Barbara Kachholz

  • SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase

    Gaëlle Laurent;Natalie J. German;Asish K. Saha;Vincent C.J. de Boer

  • Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?

    Wilfried Rossoll;Ann Kathrin Kröning;Uta Maria Ohndorf;Uta Maria Ohndorf;Clemens Steegborn;Clemens Steegborn

  • Sirtuin activators and inhibitors : Promises, achievements, and challenges

    Han Dai;David A. Sinclair;James L. Ellis;Clemens Steegborn

  • Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

    Melanie Gertz;Frank Fischer;Giang Thi Tuyet Nguyen;Mahadevan Lakshminarasimhan

  • SIRT5 regulation of ammonia-induced autophagy and mitophagy

    Lucia Polletta;Enza Vernucci;Ilaria Carnevale;Tania Arcangeli

  • Molecular details of cAMP generation in mammalian cells: a tale of two systems.

    Margarita Kamenetsky;Sabine Middelhaufe;Erin M. Bank;Lonny R. Levin

  • Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

    Tobias Rumpf;Matthias Schiedel;Berin Karaman;Claudia Roessler

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • A molecular mechanism for direct sirtuin activation by resveratrol.

    Melanie Gertz;Giang Thi Tuyet Nguyen;Frank Fischer;Benjamin Suenkel

  • Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

    Clemens Steegborn

  • Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment

    Clemens Steegborn;Tatiana N Litvin;Lonny R Levin;Jochen Buck

  • An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

    David Rauh;Frank Fischer;Melanie Gertz;Mahadevan Lakshminarasimhan;Mahadevan Lakshminarasimhan

  • The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

    Rita Machado de Oliveira;Hugo Vicente Miranda;Laetitia Francelle;Raquel Pinho;Raquel Pinho

  • Structure and Inhibition of the CO2-Sensing Carbonic Anhydrase Can2 from the Pathogenic Fungus Cryptococcus neoformans

    Christine Schlicker;Rebecca A. Hall;Daniela Vullo;Sabine Middelhaufe

  • Cryptococcus neoformans Senses CO2 through the Carbonic Anhydrase Can2 and the Adenylyl Cyclase Cac1

    Estelle Geweiss Mogensen;Guilhem Janbon;James Chaloupka;Clemens Steegborn

  • A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

    Jun Li;Michael S. Bonkowski;Sébastien Moniot;Dapeng Zhang

  • BIOCARBONATE ACTIVATION OF ADENYLYL CYCLASE VIA PROMOTION OF CATALYTIC ACTIVE SITE CLOSURE AND METAL RECRUITMENT

    C. Steegborn;T. Litvin;L. Levin;J. Buck

Frequent Co-Authors

Jochen Buck
Jochen Buck Cornell University
Mike Schutkowski
Mike Schutkowski Martin Luther University Halle-Wittenberg
Lonny R. Levin
Lonny R. Levin Cornell University
Tim Clausen
Tim Clausen Research Institute of Molecular Pathology
Robert Huber
Robert Huber Agricultural & Applied Economics Association
David A. Sinclair
David A. Sinclair Harvard University
Albrecht Messerschmidt
Albrecht Messerschmidt Max Planck Society
Antonello Mai
Antonello Mai Sapienza University of Rome
Ulrich Schweizer
Ulrich Schweizer University of Bonn
Hao Wu
Hao Wu Harvard University

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