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Chemistry

D-Index
48
Citations
8987
World Ranking
15175
National Ranking
1108

Overview

Mike Schutkowski is affiliated with Martin Luther University Halle-Wittenberg in Germany. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a total of 77 publications, and Medicine, with 31 publications. Within these main fields, subfields of study include Molecular Biology, Organic Chemistry, Oncology, Geriatrics and Gerontology, and Epidemiology.

The scientist's work concentrates on several main topics, including Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Peptidase Inhibition and Analysis, Sirtuins and Resveratrol in Medicine, Click Chemistry and Applications, Epigenetics and DNA Methylation, and Signaling Pathways in Disease. These areas reflect interdisciplinary approaches bridging biochemistry and medicinal chemistry.

Mike Schutkowski has contributed to publications in various journals. The most frequent publication venues are:

  • International Journal of Molecular Sciences
  • Journal of Medicinal Chemistry
  • Archiv der Pharmazie
  • Bioorganic Chemistry
  • ACS Chemical Biology

Their recent papers showcase a focus on histone deacetylase (HDAC) and related enzymatic activities, with research spanning from molecular docking and biological characterization to the development of selective inhibitors. Selected recent papers are:

  • The disordered N-terminus of HDAC6 is a microtubule-binding domain critical for efficient tubulin deacetylation, 2020, Journal of Biological Chemistry
  • Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity, 2021, International Journal of Molecular Sciences
  • Uncovering Robust Delactoylase and Depyruvoylase Activities of HDAC Isoforms, 2022, ACS Chemical Biology
  • Development of Alkylated Hydrazides as Highly Potent and Selective Class I Histone Deacetylase Inhibitors with T cell Modulatory Properties, 2022, Journal of Medicinal Chemistry
  • Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation, 2023, Journal of Medicinal Chemistry

Frequent collaborators include researchers who have coauthored multiple papers with Mike Schutkowski. Their most common coauthors are:

  • Wolfgang Sippl
  • Matthes Zessin
  • Sebastian Hilscher
  • Marat Meleshin
  • Cyril Bařinka

Best Publications

  • Sequence-specific and phosphorylation dependent proline isomerization: A potential mitotic regulatory mechanism

    Michael B. Yaffe;Mike Schutkowski;Minhui Shen;Xiao Zhen Zhou

  • MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

    Jérôme Boudeau;Annette F. Baas;Maria Deak;Nick A. Morrice

  • The speed limit for protein folding measured by triplet-triplet energy transfer.

    Oliver Bieri;Jakob Wirz;Bruno Hellrung;Mike Schutkowski

  • SIDE-CHAIN EFFECTS ON PEPTIDYL-PROLYL CIS/TRANS ISOMERISATION

    Ulf Reimer;Gerd Scherer;Mario Drewello;Susanne Kruber

  • Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

    Melanie Gertz;Frank Fischer;Giang Thi Tuyet Nguyen;Mahadevan Lakshminarasimhan

  • SIRT5 regulation of ammonia-induced autophagy and mitophagy

    Lucia Polletta;Enza Vernucci;Ilaria Carnevale;Tania Arcangeli

  • Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

    Tobias Rumpf;Matthias Schiedel;Berin Karaman;Claudia Roessler

  • ROLE OF PHOSPHORYLATION IN DETERMINING THE BACKBONE DYNAMICS OF THE SERINE/ THREONINE-PROLINE MOTIF AND PIN1 SUBSTRATE RECOGNITION

    Mike Schutkowski;Anne Bernhardt;Xiao Zhen Zhou;Minhui Shen

  • Barriers to Rotation of Secondary Amide Peptide Bonds

    Gerd Scherer;Michael L. Kramer;Mike Schutkowski;and Ulf Reimer

  • An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

    David Rauh;Frank Fischer;Melanie Gertz;Mahadevan Lakshminarasimhan;Mahadevan Lakshminarasimhan

  • Histone Deacetylase 11 Is a Fatty-Acid Deacylase

    Zsofia Kutil;Zora Novakova;Marat Meleshin;Jana Mikesova

  • Enhancing the Proline Effect: Pseudo-Prolines for Tailoring Cis/Trans Isomerization

    Michael Keller;Cédric Sager;Pascal Dumy;Mike Schutkowski

  • Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.

    Weijie You;Dante Rotili;Tie-Mei Li;Tie-Mei Li;Christian Kambach

  • Rotational Barriers of cis/trans Isomerization of Proline Analogues and Their Catalysis by Cyclophilin§

    Dorothee Kern;Mike Schutkowski;Torbjörn Drakenberg

  • Sirt1 activation by resveratrol is substrate sequence-selective.

    Mahadevan Lakshminarasimhan;David Rauh;Mike Schutkowski;Clemens Steegborn

  • Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening

    Angie S. Mah;Andrew E. H. Elia;Geeta Devgan;Jason Ptacek

  • Molecular Basis for the Substrate Specificity of NIMA-related Kinase-6 (NEK6) EVIDENCE THAT NEK6 DOES NOT PHOSPHORYLATE THE HYDROPHOBIC MOTIF OF RIBOSOMAL S6 PROTEIN KINASE AND SERUM- AND GLUCOCORTICOID-INDUCED PROTEIN KINASE IN VIVO

    Jose M. Lizcano;Maria Deak;Nick Morrice;Agnieszka Kieloch

  • The SH2 Domain Interaction Landscape

    Michele Tinti;Lars Kiemer;Stefano Costa;Martin L. Miller

  • Crystal Structure Analysis of Human Sirt2 and its Adp-Ribose Complex

    Sébastien Moniot;Mike Schutkowski;Clemens Steegborn

  • A protease-free assay for peptidyl prolyl cis/trans isomerases using standard peptide substrates.

    B. Janowski;S. Wöllner;M. Schutkowski;G. Fischer

  • High-content peptide microarrays for deciphering kinase specificity and biology.

    Mike Schutkowski;Ulf Reimer;Sören Panse;Liying Dong

Frequent Co-Authors

Gunter Fischer
Gunter Fischer Max Planck Society
Clemens Steegborn
Clemens Steegborn University of Bayreuth
Jens Schneider-Mergener
Jens Schneider-Mergener Humboldt-Universität zu Berlin
Markus Maeurer
Markus Maeurer Champalimaud Foundation
Wolfgang Sippl
Wolfgang Sippl Martin Luther University Halle-Wittenberg
Klaus Neubert
Klaus Neubert Martin Luther University Halle-Wittenberg
Franz Josef Conraths
Franz Josef Conraths Friedrich-Loeffler-Institut
Gianni Cesareni
Gianni Cesareni University of Rome Tor Vergata
Luisa Castagnoli
Luisa Castagnoli University of Rome Tor Vergata
Søren Brunak
Søren Brunak University of Copenhagen

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