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Biology and Biochemistry

D-Index
72
Citations
15927
World Ranking
6408
National Ranking
451

Overview

Manfred Jung is affiliated with the University of Freiburg in Germany. Their primary research spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these fields, their work notably focuses on Molecular Biology, Oncology, Geriatrics and Gerontology, Organic Chemistry, and Physiology.

The scientist's research emphasizes several key topics including Histone Deacetylase Inhibitors Research, Protein Degradation and Inhibitors, Sirtuins and Resveratrol in Medicine, Epigenetics and DNA Methylation, Peptidase Inhibition and Analysis, Ubiquitin and proteasome pathways, and PARP inhibition in cancer therapy.

Manfred Jung has contributed to multiple recent papers. These include:

  • Proteolysis targeting chimeras (PROTACs) for epigenetics research, 2020, Current Opinion in Chemical Biology
  • Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors, 2021, Journal of Medicinal Chemistry
  • Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation, 2020, European Journal of Medicinal Chemistry
  • Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation, 2020, ACS Medicinal Chemistry Letters
  • Sirtuin 1 Inhibiting Thiocyanates (S1th)-A New Class of Isotype Selective Inhibitors of NAD+ Dependent Lysine Deacetylases, 2020, Frontiers in Oncology

The scientist has published frequently in the following venues:

  • European Journal of Medicinal Chemistry
  • Journal of Medicinal Chemistry
  • ChemMedChem
  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences

Frequent co-authors collaborating with Manfred Jung include:

  • Wolfgang Sippl
  • Matthias Schmidt
  • Oliver Einsle
  • Christophe Romier
  • Dina Robaa

Best Publications

  • Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

    Julia M. Wagner;Björn Hackanson;Michael Lübbert;Manfred Jung

  • SIRT1 regulates HIV transcription via Tat deacetylation.

    Sara Pagans;Angelika Pedal;Brian J North;Katrin Kaehlcke

  • Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

    Ludovica Morera;Michael Lübbert;Manfred Jung

  • Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

    Tobias Rumpf;Matthias Schiedel;Berin Karaman;Claudia Roessler

  • Inhibitors of Histone Deacetylase as New Anticancer Agents

    Manfred Jung

  • HDAC8: a multifaceted target for therapeutic interventions

    Alokta Chakrabarti;Ina Oehme;Olaf Witt;Guilherme Oliveira

  • Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation.

    Manfred Jung;Gerald Brosch;Doris Kölle;Hans Scherf

  • Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals)

    Matthias Schiedel;Daniel Herp;Sören Hammelmann;Sören Swyter

  • Structure–Activity Studies on Suramin Analogues as Inhibitors of NAD+-Dependent Histone Deacetylases (Sirtuins)

    Johannes Trapp;Rene Meier;Darunee Hongwiset;Matthias U. Kassack

  • Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

    Johannes Trapp;Anne Jochum;Rene Meier;Laura Saunders

  • Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.

    Robert C. Neugebauer;Urszula Uchiechowska;Rene Meier;Henning Hruby

  • The Emerging Therapeutic Potential of Histone Methyltransferase and Demethylase Inhibitors

    Astrid Spannhoff;Alexander-Thomas Hauser;Ralf Heinke;Wolfgang Sippl

  • Structural Basis for the Inhibition of Histone Deacetylase 8 (Hdac8), a Key Epigenetic Player in the Blood Fluke Schistosoma Mansoni.

    Martin Marek;Srinivasaraghavan Kannan;Alexander-Thomas Hauser;Marina de Moraes Mourão

  • Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors.

    Yin Zhang;Manfred Jung;Anatoly Dritschilo;Mira Jung

  • Target-Based Approach to Inhibitors of Histone Arginine Methyltransferases

    Astrid Spannhoff;Ralf Heinke;Ingo Bauer;Patrick Trojer

  • Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.

    Stacy W. Remiszewski;Lidia C. Sambucetti;Peter Atadja;Kenneth W. Bair

  • In vitro assays for the determination of histone deacetylase activity.

    Birgit Heltweg;Johannes Trapp;Manfred Jung

  • Subtype selective substrates for histone deacetylases.

    Birgit Heltweg;Franck Dequiedt;Brett L. Marshall;Carsten Brauch

  • Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.

    Dominica Willmann;Soyoung Lim;Stefan Wetzel;Eric Metzger

  • Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

    J M Gajer;S D Furdas;A Gründer;M Gothwal

Frequent Co-Authors

Wolfgang Sippl
Wolfgang Sippl Martin Luther University Halle-Wittenberg
Roland Schüle
Roland Schüle University of Freiburg
Oliver Einsle
Oliver Einsle University of Freiburg
Raymond J. Pierce
Raymond J. Pierce University of Lille
Michael Lübbert
Michael Lübbert University of Freiburg
Eric Verdin
Eric Verdin Buck Institute for Research on Aging
Judit Ovádi
Judit Ovádi Hungarian Academy of Sciences
Lucia Altucci
Lucia Altucci University of Campania "Luigi Vanvitelli"
Gerald Brosch
Gerald Brosch Innsbruck Medical University
Simone Fulda
Simone Fulda Goethe University Frankfurt

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