2026 Matthieu Schapira: Biology and Biochemistry Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Biology and Biochemistry	61	11154	10278	386	351	272	18724

Overview

Matthieu Schapira is affiliated with the University of Toronto in Canada and has contributed extensively to the field of Biochemistry, Genetics and Molecular Biology, with a total of 143 publications. Their research spans several subfields, including Molecular Biology, Computational Theory and Mathematics, Oncology, Infectious Diseases, and Organic Chemistry.

Their main research topics cover a wide array of specialized areas such as:

Computational Drug Discovery Methods
Protein Degradation and Inhibitors
Ubiquitin and proteasome pathways
RNA and protein synthesis mechanisms
Epigenetics and DNA Methylation
Peptidase Inhibition and Analysis
Histone Deacetylase Inhibitors Research

Notable recent publications by Matthieu Schapira include:

Protein arginine methylation: from enigmatic functions to therapeutic targeting, 2021, Nature Reviews Drug Discovery
Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase, 2021, Nature Communications
A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization, 2021, Nature Chemical Biology
Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors, 2021, SLAS DISCOVERY
CACHE (Critical Assessment of Computational Hit-finding Experiments): A public-private partnership benchmarking initiative to enable the development of computational methods for hit-finding, 2022, Nature Reviews Chemistry

Their frequent co-authors include:

C.H. Arrowsmith
Rachel Harding
Suzanne Ackloo
Peter J. Brown
Masoud Vedadi

Matthieu Schapira's research has been published in multiple venues, with notable frequency in the following:

bioRxiv (Cold Spring Harbor Laboratory)
Zenodo (CERN European Organization for Nuclear Research)
Journal of Medicinal Chemistry
Journal of Chemical Information and Modeling
UNC Libraries

Best Publications

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Heather P Harding;Isabel Novoa;Yuhong Zhang;Huiqing Zeng

3684
Citations
Epigenetic protein families: a new frontier for drug discovery

Cheryl H. Arrowsmith;Chas Bountra;Paul V. Fish;Kevin Lee;Kevin Lee

1486
Citations
The promise and peril of chemical probes.

Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

883
Citations
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Damian B. Yap;Damian B. Yap;Justin Chu;Tobias Berg;Matthieu Schapira

682
Citations
Targeted protein degradation: expanding the toolbox.

Matthieu Schapira;Matthieu Schapira;Matthew F Calabrese;Alex N Bullock;Craig M Crews

663
Citations
A systematic analysis of atomic protein–ligand interactions in the PDB

Renato Ferreira de Freitas;Matthieu Schapira;Matthieu Schapira

429
Citations
Recognition and specificity determinants of the human cbx chromodomains.

Lilia Kaustov;Hui Ouyang;Maria J Amaya;Alexander Lemak

341
Citations
Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity

Anja Schuetz;Jinrong Min;Jinrong Min;Abdellah Allali-Hassani;Matthieu Schapira;Matthieu Schapira

319
Citations
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Wenyu Yu;Emma J. Chory;Emma J. Chory;Amy K. Wernimont;Wolfram Tempel

303
Citations
Structural biology of human H3K9 methyltransferases

Hong Wu;Jinrong Min;Vladimir V. Lunin;Tatiana Antoshenko

292
Citations
Protein arginine methylation: from enigmatic functions to therapeutic targeting.

Qin Wu;Matthieu Schapira;Cheryl H Arrowsmith;Cheryl H Arrowsmith;Cheryl H Arrowsmith;Dalia Barsyte-Lovejoy;Dalia Barsyte-Lovejoy

287
Citations
Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins *

Chao Xu;Ke Liu;Hazem Ahmed;Peter Loppnau

282
Citations
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

Mohammad S. Eram;Yudao Shen;Magdalena M. Szewczyk;Hong Wu

252
Citations
WD40 repeat domain proteins: a novel target class?

Matthieu Schapira;Mike Tyers;Maricel Torrent;Cheryl H. Arrowsmith;Cheryl H. Arrowsmith

251
Citations
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Florian Grebien;Masoud Vedadi;Masoud Vedadi;Matthäus Getlik;Roberto Giambruno

231
Citations
BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence

Lei Gu;Sandra C Frommel;Christopher C Oakes;Ronald Simon

231
Citations
Nuclear hormone receptor targeted virtual screening.

Matthieu Schapira;Ruben Abagyan;Maxim Totrov

229
Citations
Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking

Matthieu Schapira;Bruce M. Raaka;Sharmistha Das;Li Fan

226
Citations
Prediction of the binding energy for small molecules, peptides and proteins.

Matthieu Schapira;Maxim Totrov;Ruben Abagyan

223
Citations
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.

Dalia Barsyte-Lovejoy;Fengling Li;Menno J. Oudhoff;John H. Tatlock

182
Citations