Matthieu Schapira mostly deals with Biochemistry, Methyltransferase, Computational biology, Histone and Histone methyltransferase. His Methyltransferase research is multidisciplinary, incorporating elements of Structure–activity relationship and Transferase. Matthieu Schapira focuses mostly in the field of Structure–activity relationship, narrowing it down to matters related to DOT1L and, in some cases, Drug discovery and Chemical biology.
His work is dedicated to discovering how Computational biology, Genetics are connected with Binding selectivity and other disciplines. His Histone research incorporates elements of Multiprotein complex and Active site. In his research on the topic of Histone methyltransferase, Epigenetics, Epigenomics, Cancer epigenetics, Epigenetic regulation of neurogenesis and Epigenetics in learning and memory is strongly related with Histone methylation.
His scientific interests lie mostly in Biochemistry, Methyltransferase, Computational biology, Histone and Stereochemistry. His work on Transferase, Small molecule, Binding site and Structure–activity relationship as part of general Biochemistry research is frequently linked to Arginine, bridging the gap between disciplines. His work deals with themes such as Allosteric regulation, Cofactor, Enzyme and EZH2, which intersect with Methyltransferase.
His Computational biology research is multidisciplinary, incorporating perspectives in Genetics, Protein family, Epigenetics, Structural genomics and Drug discovery. His research in Histone focuses on subjects like Cell biology, which are connected to Protein domain. His Histone methyltransferase study also includes fields such as
His primary scientific interests are in Crystallography, Computational biology, X-ray crystallography, Methyltransferase and Histone. His Crystallography study combines topics from a wide range of disciplines, such as Viral replication and Sequence. His Computational biology research is multidisciplinary, relying on both Druggability, Methylation, Gene, Protein family and Protein degradation.
His Methyltransferase research is within the category of Biochemistry. His Binding site study in the realm of Biochemistry connects with subjects such as Genetic variability and Severe acute respiratory syndrome coronavirus 2. His Histone study combines topics in areas such as Chromatin, HEK 293 cells and Cell biology.
Matthieu Schapira mainly investigates Computational biology, Methyltransferase, Histone, Chemical biology and Small molecule. The various areas that Matthieu Schapira examines in his Computational biology study include Ubiquitin, Methylation, Protein degradation, Protein arginine methyltransferase 5 and Protein family. His Methylation study integrates concerns from other disciplines, such as Structural biology, Jurkat cells, Epigenetics and Cellular differentiation.
Methyltransferase is a subfield of Biochemistry that he tackles. His Histone study incorporates themes from HEK 293 cells and Genome instability. His Small molecule research incorporates themes from Chromatin and Tudor domain.
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Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
Heather P Harding;Isabel Novoa;Yuhong Zhang;Huiqing Zeng.
Molecular Cell (2000)
Epigenetic protein families: a new frontier for drug discovery
Cheryl H. Arrowsmith;Chas Bountra;Paul V. Fish;Kevin Lee;Kevin Lee.
Nature Reviews Drug Discovery (2012)
The promise and peril of chemical probes.
Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell.
Nature Chemical Biology (2015)
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.
Damian B. Yap;Damian B. Yap;Justin Chu;Tobias Berg;Matthieu Schapira.
Human HDAC7 Harbors a Class IIa Histone Deacetylase-specific Zinc Binding Motif and Cryptic Deacetylase Activity
Anja Schuetz;Jinrong Min;Jinrong Min;Abdellah Allali-Hassani;Matthieu Schapira;Matthieu Schapira.
Journal of Biological Chemistry (2008)
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
Wenyu Yu;Emma J. Chory;Emma J. Chory;Amy K. Wernimont;Wolfram Tempel.
Nature Communications (2012)
Recognition and specificity determinants of the human cbx chromodomains.
Lilia Kaustov;Hui Ouyang;Maria J Amaya;Alexander Lemak.
Journal of Biological Chemistry (2011)
Structural biology of human H3K9 methyltransferases
Hong Wu;Jinrong Min;Vladimir V. Lunin;Tatiana Antoshenko.
PLOS ONE (2010)
Prediction of the binding energy for small molecules, peptides and proteins.
Matthieu Schapira;Maxim Totrov;Ruben Abagyan.
Journal of Molecular Recognition (1999)
Nuclear hormone receptor targeted virtual screening.
Matthieu Schapira;Ruben Abagyan;Maxim Totrov.
Journal of Medicinal Chemistry (2003)
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