World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
26869
World Ranking
2579
National Ranking
78

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

His main research concerns Biochemistry, Genetics, Protein structure, Cell biology and Molecular biology. In most of his Biochemistry studies, his work intersects topics such as Biophysics. In general Genetics study, his work on CRISPR, Sequence alignment, DNA repair and Protein subunit often relates to the realm of CRISPR Loci, thereby connecting several areas of interest.

The various areas that he examines in his Protein structure study include Crystallization, Protein crystallization, Genomics, Structural biology and Thermotoga maritima. His studies examine the connections between Cell biology and genetics, as well as such issues in HMG-box, with regards to Origin recognition complex, Replication protein A and SeqA protein domain. His Molecular biology research is multidisciplinary, incorporating elements of Proteome, Structural proteomics, Regulator, Computational biology and Structural genomics.

His most cited work include:

  • Protein production and purification. (655 citations)
  • Architecture of RNA polymerase II and implications for the transcription mechanism. (510 citations)
  • Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination. (477 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Crystal structure, Crystallography, Biochemistry, Stereochemistry and Deposition. His Crystal structure research includes themes of Phosphatase, Biophysics, Bromodomain and Cell biology. His work is connected to Protein structure, Structural genomics, Enzyme and Escherichia coli, as a part of Biochemistry.

His research is interdisciplinary, bridging the disciplines of Ligand and Stereochemistry. He merges Deposition with Group in his study. He incorporates Group and FERM domain in his research.

He most often published in these fields:

  • Crystal structure (58.27%)
  • Crystallography (35.56%)
  • Biochemistry (24.49%)

What were the highlights of his more recent work (between 2017-2021)?

  • Crystal structure (58.27%)
  • Crystallography (35.56%)
  • Deposition (11.85%)

In recent papers he was focusing on the following fields of study:

Aled M. Edwards spends much of his time researching Crystal structure, Crystallography, Deposition, Group and Phosphatase. His studies in Crystal structure integrate themes in fields like Stereochemistry, Bromodomain, Peptide and Kinase. Aled M. Edwards studies Bromodomain, focusing on BRD4 in particular.

Aled M. Edwards integrates Crystallography and Domain in his studies. His Group research spans across into fields like FERM domain and Chemical engineering. His Pleckstrin homology domain research focuses on Space and how it relates to Group.

Between 2017 and 2021, his most popular works were:

  • Target 2035: probing the human proteome (38 citations)
  • Donated chemical probes for open science. (31 citations)
  • The RESOLUTE consortium: unlocking SLC transporters for drug discovery. (15 citations)

Best Publications

  • Protein production and purification.

    S Gräslund

  • The promise and peril of chemical probes.

    Cheryl H. Arrowsmith;James E. Audia;Christopher Austin;Jonathan Baell

  • Architecture of RNA polymerase II and implications for the transcription mechanism.

    Patrick Cramer;David A. Bushnell;Jianhua Fu;Averell L. Gnatt

  • Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.

    Masoud Vedadi;Frank H. Niesen;Abdellah Allali-Hassani;Oleg Y. Fedorov

  • Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

    Alexey Bochkarev;Richard A. Pfuetzner;Aled M. Edwards;Lori Frappier

  • A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

    Masoud Vedadi;Dalia Barsyte-Lovejoy;Feng Liu;Sylvie Rival-Gervier

  • Hepatic Gene Expression Discriminates Responders and Nonresponders in Treatment of Chronic Hepatitis C Viral Infection

    Limin Chen;Ivan Borozan;Jordan Feld;Jing Sun

  • A Call for Systematic Research on Solute Carriers

    Adrián César-Razquin;Berend Snijder;Tristan Frappier-Brinton;Ruth Isserlin

  • A proposal for validation of antibodies

    Mathias Uhlen;Anita Bandrowski;Steven Carr;Aled Edwards

  • Too many roads not taken

    Aled M Edwards;Ruth Isserlin;Gary D Bader;Stephen V Frye

  • Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.

    Vivian Saridakis;Yi Sheng;Feroz Sarkari;Melissa N. Holowaty

  • Structural proteomics of an archaeon.

    Dinesh Christendat;Adelinda Yee;Akil Dharamsi;Yuval Kluger

  • Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase family.

    Ekaterina Kuznetsova;Michael Proudfoot;Claudio F. Gonzalez;Greg Brown

  • Bridging structural biology and genomics: assessing protein interaction data with known complexes.

    Aled M Edwards;Bart Kus;Ronald Jansen;Dov Greenbaum

  • The human genome and drug discovery after a decade. Roads (still) not taken

    Ruth Isserlin;Gary D. Bader;Aled Edwards;Stephen Frye

  • A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair

    Mohan Babu;Natalia Beloglazova;Robert Flick;Chris Graham

  • Herpes Simplex Virus Triggers and Then Disarms a Host Antiviral Response

    Karen L. Mossman;Pascale F. Macgregor;Jacob J. Rozmus;Andrew B. Goryachev

  • Two dissociable subunits of yeast RNA polymerase II stimulate the initiation of transcription at a promoter in vitro.

    A M Edwards;C M Kane;R A Young;R D Kornberg

  • Structure and biochemical functions of SIRT6.

    Patricia W. Pan;Jessica L. Feldman;Mark K. Devries;Aiping Dong

  • Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

    Masoud Vedadi;Jocelyne Lew;Jennifer Artz;Mehrnaz Amani

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Opher Gileadi
Opher Gileadi Karolinska Institute
Udo Oppermann
Udo Oppermann University of Oxford
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
Alex N. Bullock
Alex N. Bullock University of Oxford
Oleg Fedorov
Oleg Fedorov University of Oxford
Alexei Savchenko
Alexei Savchenko University of Calgary
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Masoud Vedadi
Masoud Vedadi Structural Genomics Consortium

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