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Biology and Biochemistry

D-Index
54
Citations
10334
World Ranking
15647
National Ranking
239

Overview

Opher Gileadi is affiliated with the Karolinska Institute in Sweden. Their research primarily lies within the broad domain of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Cell Biology, Infectious Diseases, Organic Chemistry, and Immunology as significant subfields of study.

The scientist's main research topics include:

  • SARS-CoV-2 and COVID-19 Research
  • Protein Kinase Regulation and GTPase Signaling
  • DNA Repair Mechanisms
  • Proteoglycans and glycosaminoglycans research
  • Click Chemistry and Applications
  • Computational Drug Discovery Methods
  • Glycosylation and Glycoproteins Research

Opher Gileadi has contributed to several research articles, including the following recent papers:

  • Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase, 2021, Nature Communications
  • Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification, 2021, Nucleic Acids Research
  • STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers, 2020, Life Science Alliance
  • Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • The SNM1A DNA repair nuclease, 2020, DNA repair

The frequent coauthors contributing to Opher Gileadi's publications include:

  • J.A. Newman
  • V.L. Katis
  • W.J. Bradshaw
  • Y. Yosaatmadja
  • Paul E. Brennan

The most common venues where Gileadi's research is published are:

  • Zenodo (CERN European Organization for Nuclear Research)
  • bioRxiv (Cold Spring Harbor Laboratory)
  • UNC Libraries
  • Nucleic Acids Research
  • Methods in molecular biology

Best Publications

  • Protein production and purification.

    S Gräslund

  • Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study

    Nicola A. Burgess-Brown;Sujata Sharma;Frank Sobott;Christoph Loenarz

  • Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

    Stanley S. Ng;Kathryn L. Kavanagh;Michael A. McDonough;Danica Butler

  • High-throughput production of human proteins for crystallization: the SGC experience.

    Pavel Savitsky;James Bray;Christopher D.O. Cooper;Brian D. Marsden

  • Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.

    S K Sieberts;T M Perumal;M M Carrasquillo;M Allen

  • CTD kinase associated with yeast RNA polymerase II initiation factor b

    William J. Feaver;Opher Gileadi;Yang Li;Roger D. Kornberg

  • Scanning electron microscopy of cells and tissues under fully hydrated conditions

    Stephan Thiberge;Amotz Nechushtan;David Sprinzak;Opher Gileadi

  • Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

    Peter Canning;Christopher D.O. Cooper;Tobias Krojer;James W. Murray

  • Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states

    Chitra A. Shintre;Ashley C. W. Pike;Qiuhong Li;Jung-In Kim

  • An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae.

    Michael S Kobor;Jacques Archambault;William Lester;Frank C.P Holstege

  • Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair

    Bruno Vaz;Marta Popovic;Joseph A. Newman;John Fielden

  • Structural Basis of Metallo-β-Lactamase Inhibition by Captopril Stereoisomers

    Jürgen Brem;Sander S. van Berkel;David Zollman;Sook Y. Lee

  • Reversible Sequestration of Active Site Cysteines in a 2Fe-2S-bridged Dimer Provides a Mechanism for Glutaredoxin 2 Regulation in Human Mitochondria

    Catrine Johansson;Kathryn L. Kavanagh;Opher Gileadi;Udo Oppermann

  • Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases

    Dawei Chen;Melanie Vollmar;Marianna N Rossi;Claire Phillips

  • Human SNM1A and XPF–ERCC1 collaborate to initiate DNA interstrand cross-link repair

    Anderson T. Wang;Blanka Sengerová;Emma Cattell;Takabumi Inagawa

  • Progress towards a public chemogenomic set for protein kinases and a call for contributions

    David H. Drewry;Carrow I. Wells;David M. Andrews;Richard Angell

  • Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.

    Joseph A Newman;Alice Douangamath;Setayesh Yadzani;Yuliana Yosaatmadja

  • Compaction of single DNA molecules induced by binding of integration host factor (IHF).

    B. M. Jaffar Ali;Roee Amit;Ido Braslavsky;Amos B. Oppenheim

  • A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells.

    Giang Huong Nguyen;Thomas S. Dexheimer;Andrew S. Rosenthal;Wai Kit Chu

  • Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72

    Carl Laflamme;Paul M McKeever;Rahul Kumar;Julie Schwartz

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Adrian Edwards
Adrian Edwards Cardiff University
Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Oleg Fedorov
Oleg Fedorov University of Oxford
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
Alessandro Vindigni
Alessandro Vindigni Washington University in St. Louis
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Alex N. Bullock
Alex N. Bullock University of Oxford

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