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Molecular Biology
France
2026
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Genetics and Molecular Biology
France
2024

D-Index & Metrics

Molecular Biology

D-Index
101
Citations
30119
World Ranking
517
National Ranking
9

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in France Leader Award
  • 2025 - Research.com Molecular Biology in France Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in France Leader Award
  • 2023 - Research.com Molecular Biology in France Leader Award

Overview

Jean-Marc Egly is affiliated with the Institute of Genetics and Molecular and Cellular Biology in France. Their research spans multiple intersecting fields within biochemistry, genetics, molecular biology, and medicine. The scientist's work concentrates particularly on molecular and cellular mechanisms relevant to oncology and neurology.

Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these areas, the subfields of study addressed are:

  • Molecular Biology
  • Oncology
  • Epidemiology
  • Neurology
  • Cell Biology

The primary research topics covered by Jean-Marc Egly's work are:

  • Lung Cancer Research Studies
  • Neuroendocrine Tumor Research Advances
  • Ubiquitin and proteasome pathways
  • DNA Repair Mechanisms
  • Protein Degradation and Inhibitors
  • Neuroblastoma Research and Treatments
  • Microtubule and mitosis dynamics

The scientist has coauthored papers frequently with:

  • Federico Costanzo
  • Emmanuel Compe
  • Frédéric Coin
  • Marta Martínez
  • Gema Santamaría Núñez

Several recent publications highlight the scope and direction of their research. These include:

  • "Promoters of ASCL1- and NEUROD1-dependent genes are specific targets of lurbinectedin in SCLC cells" (2022) published in EMBO Molecular Medicine
  • "The Cockayne syndrome group A and B proteins are part of a ubiquitin-proteasome degradation complex regulating cell division" (2020) published in Proceedings of the National Academy of Sciences
  • "CDK7 and MITF repress a transcription program involved in survival and drug tolerance in melanoma" (2021) published in EMBO Reports
  • "CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division" (2024) published in Trends in Cell Biology
  • "Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity" (2025) published in Nature Communications

The venues where Jean-Marc Egly most frequently publishes include:

  • EMBO Molecular Medicine
  • Proceedings of the National Academy of Sciences
  • Trends in Cell Biology
  • Nature Communications
  • EMBO Reports

Best Publications

  • Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

    Abdelilah Aboussekhra;Maureen Biggerstaff;Mahmud K.K. Shivji;Juhani A. Vilpo

  • DNA repair helicase: a component of BTF2 (TFIIH) basic transcription factor

    Laurent Schaeffer;Richard Roy;Sandrine Humbert;Vincent Moncollin

  • p53 modulation of TFIIH-associated nucleotide excision repair activity.

    Xin Wei Wang;H. Yeh;L. Schaeffer;Richard Roy

  • Mechanism of open complex and dual incision formation by human nucleotide excision repair factors.

    Elizabeth Evans;Jonathan G. Moggs;Jae R. Hwang;Jean Marc Egly

  • Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II

    Hua Lu;Leigh Zawel;Laurent Fisher;Jean-Marc Egly

  • The comings and goings of nucleotide excision repair factors on damaged DNA

    Thilo Riedl;Fumio Hanaoka;Jean‐Marc Egly

  • The MO15 cell cycle kinase is associated with the TFIIH transcription-DNA repair factor

    Richard Roy;Jörg P. Adamczewski;Thierry Seroz;Wim Vermeulen

  • The ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor.

    L. Schaeffer;V. Moncollin;Richard Roy;A. Staub

  • Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences.

    Barry L. Davison;Jean-Marc Egly;Eileen R. Mulvihill;Pierre Chambon

  • Stimulation of RARα Activation Function AF-1 through Binding to the General Transcription Factor TFIIH and Phosphorylation by CDK7

    Cécile Rochette-Egly;Sylvie Adam;Mireille Rossignol;Jean-Marc Egly

  • Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK

    Sofia J. Araújo;Franck Tirode;Frederic Coin;Helmut Pospiech;Helmut Pospiech

  • Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.

    Franck Tirode;Didier Busso;Frédéric Coin;Jean-Marc Egly

  • A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A

    Giuseppina Giglia-Mari;Frederic Coin;Jeffrey A Ranish;Deborah Hoogstraten

  • TFIIH: when transcription met DNA repair

    Emmanuel Compe;Jean-Marc Egly

  • TFIIH Transcription Factor, a Target for the Rift Valley Hemorrhagic Fever Virus

    Nicolas Le May;Sandy Dubaele;Luca Proietti De Santis;Agnès Billecocq

  • Activation of Estrogen Receptor α by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7

    Dongsheng Chen;Thilo Riedl;Elinor Washbrook;Paul E. Pace

  • The multiple roles of transcription/repair factor TFIIH.

    Jesper Q. Svejstrup;Paul Vichi;Jean-Marc Egly

  • Distinct roles for the XPB/p52 and XPD/p44 subcomplexes of TFIIH in damaged DNA opening during nucleotide excision repair.

    Frédéric Coin;Valentyn Oksenych;Jean-Marc Egly

  • A yeast activity can substitute for the HeLa cell TATA box factor

    Bruno Cavallini;Janine Huet;Jean-Luc Plassat;André Sentenac

  • The Cockayne syndrome B protein, involved in transcription‐coupled DNA repair, resides in an RNA polymerase II‐containing complex

    Alain J. van Gool;Elisabetta Citterio;Suzanne Rademakers;Roselinde van Os

Frequent Co-Authors

Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Pierre Chambon
Pierre Chambon Institute of Genetics and Molecular and Cellular Biology
Dino Moras
Dino Moras Institute of Genetics and Molecular and Cellular Biology
Miria Stefanini
Miria Stefanini National Research Council (CNR)
Paul Mandel
Paul Mandel Centre national de la recherche scientifique, CNRS
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam
Sandrine Humbert
Sandrine Humbert Grenoble Alpes University
Cécile Rochette-Egly
Cécile Rochette-Egly Institute of Genetics and Molecular and Cellular Biology
Alan R. Lehmann
Alan R. Lehmann University of Sussex

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