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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Genetics

D-Index
104
Citations
36237
World Ranking
651
National Ranking
98

Molecular Biology

D-Index
104
Citations
36237
World Ranking
469
National Ranking
34

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2010 - Fellow of the Royal Society, United Kingdom

Overview

Alan R. Lehmann is affiliated with the University of Sussex in the United Kingdom. Their primary research focus lies within the broad field of Biochemistry, Genetics, and Molecular Biology, with significant contributions to Molecular Biology, Genetics, Cancer Research, Neurology, and Cellular and Molecular Neuroscience.

Their scientific investigations prominently address topics such as DNA repair mechanisms, RNA regulation and disease, cancer genomics and diagnostics, RNA modifications and cancer, molecular biology techniques and applications, mitochondrial function and pathology, and genetics and neurodevelopmental disorders.

Lehmann's research has been disseminated through numerous papers across various prestigious venues. Some notable recent publications include:

  • "Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy," 2021, Human Molecular Genetics
  • "Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients," 2023, Nature Communications
  • "Neurological disease in xeroderma pigmentosum: prospective cohort study of its features and progression," 2023, Brain
  • "Molecular analysis directs the prognosis, management and treatment of patients with xeroderma pigmentosum," 2020, DNA Repair
  • "The Spectrum of MORC2-Related Disorders: A Potential Link to Cockayne Syndrome," 2023, Pediatric Neurology

Frequent coauthors who have collaborated with Lehmann include Hiva Fassihi, Robert Sarkany, Shehla Mohammed, Tomoo Ogi, and Heather Fawcett.

Their work is published in a variety of scientific journals, with repeated contributions to the British Journal of Dermatology, bioRxiv (Cold Spring Harbor Laboratory), Journal of Investigative Dermatology, Journal of Clinical Investigation, and Human Molecular Genetics.

Across their career, Alan R. Lehmann has received recognition such as being named a Fellow of the Royal Society in the United Kingdom in 2010.

Best Publications

  • Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

    A. M. R. Taylor;D. G. Harnden;C. F. Arlett;S. A. Harcourt

  • Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA: A Possible Mechanism for the Polymerase Switch in Response to DNA Damage

    Patricia L Kannouche;Jonathan Wing;Alan R Lehmann

  • Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.

    A. R. Lehmann;S. Kirk-Bell;C. F. Arlett;M. C. Paterson

  • Y-family DNA polymerases and their role in tolerance of cellular DNA damage

    Julian E. Sale;Alan R. Lehmann;Roger Woodgate

  • Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

    Marzena Bienko;Catherine M. Green;Nicola Crosetto;Fabian Rudolf

  • Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

    Guillermo E. Taccioli;Tanya M. Gottlieb;Tracy Blunt;Anne Priestley

  • DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.

    Alan R. Lehmann

  • The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

    Karla A. Henning;Lei Li;Narayan Iyer;Lisa D. McDaniel

  • Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

    A. de Klein;M. Muijtjens;R. van Os;Y. Verhoeven

  • DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

    Xianmin Zeng;David B. Winter;Cynthia Kasmer;Kenneth H. Kraemer

  • Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum

    Lynne V. Mayne;Alan R. Lehmann

  • Trading places: how do DNA polymerases switch during translesion DNA synthesis?

    Errol C. Friedberg;Alan R. Lehmann;Robert P.P. Fuchs

  • The xeroderma pigmentosum group D (XPD) gene: one gene, two functions, three diseases

    Alan R. Lehmann

  • Identification and characterization of new elements involved in checkpoint and feedback controls in fission yeast.

    F. Al-Khodairy;E. Fotou;K. S. Sheldrick;D. J. F. Griffiths

  • Translesion synthesis: Y-family polymerases and the polymerase switch

    Alan R. Lehmann;Atsuko Niimi;Tomoo Ogi;Stephanie Brown

  • Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient

    Riballo E;Critchlow Se;Teo Sh;Doherty Aj

  • Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

    Tomoo Ogi;Siripan Limsirichaikul;Siripan Limsirichaikul;René M. Overmeer;Marcel Volker

  • Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

    Tracy Blunt;David Gell;Margaret Fox;Guillermo E Taccioli

  • Domain structure, localization, and function of DNA polymerase η, defective in xeroderma pigmentosum variant cells

    Patricia Kannouche;Bernard C. Broughton;Marcel Volker;Fumio Hanaoka

  • Erratum: Trading places: How do DNA polymerases switch during translesion DNA synthesis? (Molecular Cell (May 27, 2005) 18 (499-505) PII: S1097-2765(05)01276-1 and DOI: 10.1016/j.molcel.2005.03.032)

    Errol C. Friedberg;Alan R. Lehmann;Robert P P Fuchs

Frequent Co-Authors

Colin F. Arlett
Colin F. Arlett University of Sussex
Miria Stefanini
Miria Stefanini National Research Council (CNR)
Antony M. Carr
Antony M. Carr University of Sussex
Alain Sarasin
Alain Sarasin Institut Gustave Roussy
Nicolaas G. J. Jaspers
Nicolaas G. J. Jaspers Erasmus University Rotterdam
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Wim Vermeulen
Wim Vermeulen Erasmus University Rotterdam
Michael H.L. Green
Michael H.L. Green University of Brighton
Robert P. P. Fuchs
Robert P. P. Fuchs Centre national de la recherche scientifique, CNRS
Fumio Hanaoka
Fumio Hanaoka National Institute of Genetics

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