2010 - Fellow of the Royal Society, United Kingdom
Molecular biology, Genetics, DNA repair, Nucleotide excision repair and Xeroderma pigmentosum are his primary areas of study. His work carried out in the field of Molecular biology brings together such families of science as Mutation, DNA ligase and Ku Protein, Protein kinase A. His studies examine the connections between DNA repair and genetics, as well as such issues in Cancer research, with regards to Radiation sensitivity.
He works mostly in the field of Nucleotide excision repair, limiting it down to topics relating to DDB1 and, in certain cases, Gene cluster, Therapeutic gene modulation and Ku80. His work in the fields of Xeroderma pigmentosum, such as Cockayne syndrome and Trichothiodystrophy, intersects with other areas such as Ultraviolet light. His DNA polymerase research integrates issues from Proliferating cell nuclear antigen, DNA replication and Cell biology.
His primary areas of investigation include Genetics, Molecular biology, DNA repair, Xeroderma pigmentosum and DNA. His work deals with themes such as Mutation, Mutant, DNA polymerase, Proliferating cell nuclear antigen and DNA replication, which intersect with Molecular biology. His DNA polymerase research includes elements of Polymerase and DNA polymerase eta.
His research in DNA repair is mostly focused on Nucleotide excision repair. His research in Xeroderma pigmentosum intersects with topics in Complementation, Cancer research and Skin cancer. The DNA study combines topics in areas such as Cell culture and Mutagenesis.
Alan R. Lehmann mostly deals with DNA repair, Genetics, Molecular biology, Xeroderma pigmentosum and Cell biology. His work on Nucleotide excision repair as part of general DNA repair research is often related to DNA clamp, thus linking different fields of science. The concepts of his Molecular biology study are interwoven with issues in DNA polymerase, Replication factor C, DNA repair protein XRCC4 and Proliferating cell nuclear antigen.
Alan R. Lehmann has researched Xeroderma pigmentosum in several fields, including Dermatology, Disease and Skin cancer. His Cell biology research incorporates elements of Chromatin, DNA damage and DNA replication, Eukaryotic DNA replication. His research in Cockayne syndrome intersects with topics in ERCC8, Surgery and Mutation.
Alan R. Lehmann mainly focuses on DNA repair, Molecular biology, Xeroderma pigmentosum, Nucleotide excision repair and DNA damage. His DNA repair study introduces a deeper knowledge of Genetics. His Molecular biology research includes themes of Replication protein A, DNA replication and Proliferating cell nuclear antigen.
His study looks at the intersection of Xeroderma pigmentosum and topics like Dermatology with Disease, Skin cancer and Pathology. His Nucleotide excision repair research includes elements of RNA, Lymphoblast, Deoxyuridine and DNA mismatch repair. His DNA damage research is multidisciplinary, incorporating elements of G2-M DNA damage checkpoint, Cell biology and DNA polymerase.
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Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity
A. M. R. Taylor;D. G. Harnden;C. F. Arlett;S. A. Harcourt.
Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA: A Possible Mechanism for the Polymerase Switch in Response to DNA Damage
Patricia L Kannouche;Jonathan Wing;Alan R Lehmann.
Molecular Cell (2004)
Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.
A. R. Lehmann;S. Kirk-Bell;C. F. Arlett;M. C. Paterson.
Proceedings of the National Academy of Sciences of the United States of America (1975)
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Marzena Bienko;Catherine M. Green;Nicola Crosetto;Fabian Rudolf.
Y-family DNA polymerases and their role in tolerance of cellular DNA damage
Julian E. Sale;Alan R. Lehmann;Roger Woodgate.
Nature Reviews Molecular Cell Biology (2012)
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
Guillermo E. Taccioli;Tanya M. Gottlieb;Tracy Blunt;Anne Priestley.
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
Alan R. Lehmann.
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
Karla A. Henning;Lei Li;Narayan Iyer;Lisa D. McDaniel.
DNA polymerase η is an A-T mutator in somatic hypermutation of immunoglobulin variable genes
Xianmin Zeng;David B. Winter;Cynthia Kasmer;Kenneth H. Kraemer.
Nature Immunology (2001)
Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum
Lynne V. Mayne;Alan R. Lehmann.
Cancer Research (1982)
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