D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 93 Citations 30,130 174 World Ranking 584 National Ranking 75

Research.com Recognitions

Awards & Achievements

Fellow of The Academy of Medical Sciences, United Kingdom

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • DNA
  • Mutation

The scientist’s investigation covers issues in Molecular biology, DNA repair, DNA damage, DNA and Cell biology. Her work deals with themes such as Mutant, Endonuclease, Nucleotide excision repair, Phosphorylation and Ku Protein, which intersect with Molecular biology. Her DNA repair study deals with the bigger picture of Genetics.

Her DNA damage study combines topics in areas such as Ataxia Telangiectasia Mutated Proteins and DNA-binding protein. While the research belongs to areas of DNA, she spends her time largely on the problem of Mutation, intersecting her research to questions surrounding Cell culture. Her Cell biology study incorporates themes from Chromatin, Cell cycle checkpoint and Radiosensitivity.

Her most cited work include:

  • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. (836 citations)
  • A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci (732 citations)
  • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. (684 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of investigation include DNA repair, Molecular biology, Cell biology, DNA and Genetics. Her study in DNA repair is interdisciplinary in nature, drawing from both Ku80 and DNA damage. Her work focuses on many connections between DNA damage and other disciplines, such as Cancer research, that overlap with her field of interest in Radiation therapy.

Her Molecular biology research is multidisciplinary, incorporating elements of Chinese hamster ovary cell, Mutation, Mutant, DNA ligase and Ataxia Telangiectasia Mutated Proteins. Her Cell biology research integrates issues from CHEK1, Cell cycle checkpoint, G2-M DNA damage checkpoint, Homologous recombination and Chromatin. Her Double strand, Heterochromatin and Endonuclease study in the realm of DNA connects with subjects such as Resection.

She most often published in these fields:

  • DNA repair (39.91%)
  • Molecular biology (38.63%)
  • Cell biology (39.06%)

What were the highlights of her more recent work (between 2013-2021)?

  • Cell biology (39.06%)
  • DNA (34.76%)
  • Chromatin (13.73%)

In recent papers she was focusing on the following fields of study:

Penny A. Jeggo mainly focuses on Cell biology, DNA, Chromatin, Homologous recombination and DNA repair. The Cell biology study combines topics in areas such as Ataxia-telangiectasia, DNA damage and Genetics, Apoptosis. Penny A. Jeggo regularly ties together related areas like Molecular biology in her DNA studies.

Her research in Molecular biology focuses on subjects like Exonuclease, which are connected to MRE11 Homologue Protein, MRN complex and Endonuclease. The study incorporates disciplines such as RAD51, Histone and Cell cycle in addition to Chromatin. Penny A. Jeggo usually deals with DNA repair and limits it to topics linked to Genome instability and Transcription factor, Cell cycle checkpoint, Cancer cell and Transcription.

Between 2013 and 2021, her most popular works were:

  • DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities. (326 citations)
  • DNA repair, genome stability and cancer: a historical perspective (302 citations)
  • DNA DSB repair pathway choice: an orchestrated handover mechanism (179 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Mutation

Penny A. Jeggo focuses on Cell biology, Homologous recombination, DNA repair, Genetics and DNA. She has included themes like Replication protein A and Exonuclease in her Homologous recombination study. Her DNA repair study which covers Genome instability that intersects with Transcription factor and Transcription.

Her study in Genetics concentrates on DNA damage and Chromatin. In most of her DNA studies, her work intersects topics such as Plasma protein binding. Her work carried out in the field of Non-homologous end joining brings together such families of science as Molecular biology, PLK3 and DNA repair protein XRCC4.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

Tom Stiff;Mark O’Driscoll;Nicole Rief;Kuniyoshi Iwabuchi.
Cancer Research (2004)

1316 Citations

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

Enriqueta Riballo;Martin Kühne;Nicole Rief;Aidan Doherty.
Molecular Cell (2004)

929 Citations

ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

Aaron A. Goodarzi;Angela T. Noon;Dorothee Deckbar;Yael Ziv.
Molecular Cell (2008)

891 Citations

A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

Mark O'Driscoll;Victor L Ruiz-Perez;C Geoffrey Woods;Penny A Jeggo.
Nature Genetics (2003)

876 Citations

The role of double-strand break repair - insights from human genetics

Mark O'Driscoll;Penny A. Jeggo.
Nature Reviews Genetics (2006)

744 Citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

Guillermo E. Taccioli;Tanya M. Gottlieb;Tracy Blunt;Anne Priestley.
Science (1994)

712 Citations

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

Markus Löbrich;Penny A. Jeggo.
Nature Reviews Cancer (2007)

695 Citations

γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

Markus Löbrich;Atsushi Shibata;Andrea Beucher;Anna Fisher.
Cell Cycle (2010)

643 Citations

Impairment of V(D)J recombination in double-strand break repair mutants

Guillermo E. Taccioli;Gary Rathbun;Eugene Oltz;Thomas Stamato.
Science (1993)

635 Citations

The life and death of DNA-PK

Spencer J Collis;Theodore L DeWeese;Penelope A Jeggo;Antony R Parker.
Oncogene (2005)

563 Citations

Editorial Boards

DNA Repair
(Impact Factor: 4.354)

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