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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Molecular Biology

D-Index
107
Citations
39963
World Ranking
415
National Ranking
27

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom

Overview

Penny A. Jeggo is affiliated with the University of Sussex in the United Kingdom. Their research primarily focuses on biochemistry, genetics, and molecular biology with significant contributions in medicine. The scientist's work emphasizes molecular biology, oncology, cancer research, pulmonary and respiratory medicine, and immunology.

The research topics covered in their publications include:

  • DNA Repair Mechanisms
  • Carcinogens and Genotoxicity Assessment
  • Radiation Therapy and Dosimetry
  • Cancer-related Molecular Pathways
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy
  • Effects of Radiation Exposure

Recent publications by Penny A. Jeggo include:

  • Roles for 53BP1 in the repair of radiation-induced DNA double strand breaks (2020), DNA Repair
  • ATM's Role in the Repair of DNA Double-Strand Breaks (2021), Genes
  • Roles for the DNA-PK complex and 53BP1 in protecting ends from resection during DNA double-strand break repair (2020), Journal of Radiation Research
  • Canonical DNA non-homologous end-joining; capacity versus fidelity (2020), British Journal of Radiology
  • DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling (2020), Genome Instability & Disease

The most frequent publication venues for their work are:

  • DNA Repair
  • British Journal of Radiology
  • Genes
  • Journal of Radiation Research
  • Genome Instability & Disease

Penny A. Jeggo has collaborated regularly with other researchers, including:

  • Atsushi Shibata
  • Navita Somaiah
  • Jessica A. Downs
  • Lisa Woodbine
  • Kaye J. Williams

Among the recognitions, Penny A. Jeggo has been awarded fellowship status as a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

    Tom Stiff;Mark O’Driscoll;Nicole Rief;Kuniyoshi Iwabuchi

  • Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation

    Tracy Blunt;Nicholas J Finnie;Guillermo E Taccioli;Guillermo E Taccioli;Graeme C.M Smith

  • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

    Enriqueta Riballo;Martin Kühne;Nicole Rief;Aidan Doherty

  • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

    Aaron A. Goodarzi;Angela T. Noon;Dorothee Deckbar;Yael Ziv

  • A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

    Mark O'Driscoll;Victor L Ruiz-Perez;C Geoffrey Woods;Penny A Jeggo

  • The role of double-strand break repair - insights from human genetics

    Mark O'Driscoll;Penny A. Jeggo

  • The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

    Markus Löbrich;Penny A. Jeggo

  • Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

    Guillermo E. Taccioli;Tanya M. Gottlieb;Tracy Blunt;Anne Priestley

  • DNA repair, genome stability and cancer: a historical perspective

    Penny A. Jeggo;Laurence H. Pearl;Antony M. Carr

  • γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

    Markus Löbrich;Atsushi Shibata;Andrea Beucher;Anna Fisher

  • Impairment of V(D)J recombination in double-strand break repair mutants

    Guillermo E. Taccioli;Gary Rathbun;Eugene Oltz;Thomas Stamato

  • DNA repair is limiting for haematopoietic stem cells during ageing

    Anastasia Nijnik;Lisa Woodbine;Caterina Marchetti;Caterina Marchetti;Sara Dawson

  • ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

    Andrea Beucher;Julie Birraux;Leopoldine Tchouandong;Olivia Barton

  • DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities.

    Atsushi Shibata;Atsushi Shibata;Davide Moiani;Davide Moiani;Andrew S. Arvai;Andrew S. Arvai;Jefferson Perry;Jefferson Perry;Jefferson Perry

  • DNA Ligase IV Mutations Identified in Patients Exhibiting Developmental Delay and Immunodeficiency

    Mark O'Driscoll;Karen M. Cerosaletti;Pierre M. Girard;Yan Dai

  • The life and death of DNA-PK

    Spencer J Collis;Theodore L DeWeese;Penelope A Jeggo;Antony R Parker

  • DNA breakage and repair.

    Jeggo Pa

  • Factors determining DNA double-strand break repair pathway choice in G2 phase.

    Atsushi Shibata;Sandro Conrad;Julie Birraux;Verena Geuting

  • X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents.

    P.A. Jeggo;L.M. Kemp

  • Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

    Atsushi Hirao;Alison Cheung;Gordon Duncan;Pierre Marie Girard

Frequent Co-Authors

Markus Löbrich
Markus Löbrich Technical University of Darmstadt
Mark O'Driscoll
Mark O'Driscoll University of Sussex
Andrew R. Gennery
Andrew R. Gennery Newcastle University
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Aidan J. Doherty
Aidan J. Doherty University of Sussex
Alan R. Lehmann
Alan R. Lehmann University of Sussex
Andrew P. Jackson
Andrew P. Jackson University of Edinburgh
Patrick Concannon
Patrick Concannon University of Florida
Antony M. Carr
Antony M. Carr University of Sussex
Peter Hoskin
Peter Hoskin University of Manchester

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