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Genetics and Molecular Biology
China
2024
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Molecular Biology
China
2023

D-Index & Metrics

Molecular Biology

D-Index
111
Citations
46025
World Ranking
355
National Ranking
207

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in China Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in China Leader Award
  • 2023 - Research.com Molecular Biology in China Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in China Leader Award

Overview

David J. Chen is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a specific focus on Molecular Biology, Pulmonary and Respiratory Medicine, Oncology, Surgery, and Cancer Research.

The scientist's main research topics include:

  • Epigenetics and DNA Methylation
  • Histone Deacetylase Inhibitors Research
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • COVID-19 and healthcare impacts
  • Pneumothorax, Barotrauma, Emphysema
  • Respiratory Support and Mechanisms

David J. Chen has contributed to a number of scientific publications, with recent papers highlighting a diverse range of areas within surgery, oncology, and molecular biology. Selected recent works include:

  • "Thoracic surgery outcomes for patients with Coronavirus Disease 2019," 2021, Journal of Thoracic and Cardiovascular Surgery
  • "Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system," 2024, Nature Communications
  • "Modified Warden operation using aortic homograft," 2020, JTCVS Techniques
  • "Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting," 2024, npj Precision Oncology
  • "Femoral artery homograft for coronary artery plasty following arterial switch operation," 2020, JTCVS Techniques

Publications frequently appear in venues such as npj Precision Oncology, JTCVS Techniques, bioRxiv (Cold Spring Harbor Laboratory), Journal of Thoracic and Cardiovascular Surgery, and Nature Communications.

The scientist has collaborated often with several co-authors, including Sándor Spisák, Pornlada Likasitwatanakul, Nilay S. Sethi, James M. Cleary, and Khoa Doan. These repeated collaborations suggest a consistent research network and multidisciplinary engagement across related fields.

Best Publications

  • Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

    Fredrick S. Leach;Nicholas C. Nicolaides;Nickolas Papadopoulos;Bo Liu

  • ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

    Sandeep Burma;Benjamin P. Chen;Michael Murphy;Akihiro Kurimasa

  • Stimulation of bone formation in vitro and in rodents by statins.

    G. Mundy;R. Garrett;S. Harris;J. Chan

  • Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

    Utz Herbig;Wendy A Jobling;Benjamin P.C Chen;David J Chen

  • The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.

    Bao N. Puente;Wataru Kimura;Shalini A. Muralidhar;Jesung Moon

  • XRCC2 and XRCC3, New Human Rad51-Family Members, Promote Chromosome Stability and Protect against DNA Cross-Links and Other Damages

    Nan Liu;Jane E. Lamerdin;Robert S. Tebbs;David Schild

  • Genomic instability in laminopathy-based premature aging

    Baohua Liu;Jianming Wang;Kui Ming Chan;Wai Mui Tjia

  • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase

    Klaus Dittmann;Claus Mayer;Birgit Fehrenbacher;Martin Schaller

  • DNA double strand break repair via non-homologous end-joining

    Anthony J. Davis;David J. Chen

  • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.

    Doug W. Chan;Doug W. Chan;Benjamin Ping Chi Chen;Sheela Prithivirajsingh;Akihiro Kurimasa;Akihiro Kurimasa

  • Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages.

    D. Chen;X. Ji;M.A. Harris;J.Q. Feng

  • Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

    Naoya Uematsu;Eric Weterings;Ken Ichi Yano;Keiko Morotomi-Yano

  • The endless tale of non-homologous end-joining.

    Eric Weterings;David J Chen

  • Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

    Sandeep Burma;Benjamin P.C. Chen;David J. Chen

  • DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

    Susan M. Bailey;Julianne Meyne;David J. Chen;Akihiro Kurimasa

  • Differential effects of equiaxial and uniaxial strain on mesenchymal stem cells.

    Jennifer S. Park;Julia S.F. Chu;Catherine Cheng;Fanqing Chen

  • Ku is associated with the telomere in mammals

    Hsin Ling Hsu;David Gilley;David Gilley;Elizabeth H. Blackburn;David J. Chen

  • Ku acts in a unique way at the mammalian telomere to prevent end joining

    Hsin Ling Hsu;David Gilley;Sanjeev A. Galande;M. Prakash Hande

  • Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks

    Lilach Moyal;Yaniv Lerenthal;Mali Gana-Weisz;Gilad Mass

  • Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

    Akihiro Kurimasa;Satoshi Kumano;Satoshi Kumano;Nikolai V. Boubnov;Michael D. Story

Frequent Co-Authors

Benjamin P C Chen
Benjamin P C Chen The University of Texas Southwestern Medical Center
Gloria C. Li
Gloria C. Li Memorial Sloan Kettering Cancer Center
Hatsumi Nagasawa
Hatsumi Nagasawa Colorado State University
John B. Little
John B. Little Harvard University
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Yosef Shiloh
Yosef Shiloh Tel Aviv University
Mitsuo Oshimura
Mitsuo Oshimura Tottori University
Robert K. Moyzis
Robert K. Moyzis University of California, Irvine
Sankar Mitra
Sankar Mitra Houston Methodist
Yuan Chen
Yuan Chen University of Sydney

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