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Mitsuo Oshimura

Mitsuo Oshimura

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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Genetics

D-Index
93
Citations
31640
World Ranking
972
National Ranking
37

Molecular Biology

D-Index
93
Citations
31640
World Ranking
678
National Ranking
49

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Mitsuo Oshimura is affiliated with Tottori University in Japan and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, as well as medicine. Their research spans multiple subfields such as molecular biology, genetics, oncology, radiology, nuclear medicine and imaging, and public health, environmental and occupational health.

The scientist's work largely focuses on topics including CRISPR and genetic engineering, virus-based gene therapy research, monoclonal and polyclonal antibodies research, RNA interference and gene delivery, genomic variations and chromosomal abnormalities, pluripotent stem cells research, and viral infectious diseases and gene expression in insects.

Mitsuo Oshimura's recent noteworthy publications include:

  • A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21 (2020, eLife)
  • A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site (2021, Immunity)
  • A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features (2022, The American Journal of Human Genetics)
  • Transchromosomic technology for genomically humanized animals (2020, Experimental Cell Research)
  • Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells (2020, Journal for ImmunoTherapy of Cancer)

Frequent publication venues for their research include:

  • Scientific Reports
  • Research Square (Research Square)
  • Molecular Therapy - Nucleic Acids
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research

Collaborations have been established with several frequent co-authors, including:

  • Yasuhiro Kazuki
  • Satoshi Abe
  • Kanako Kazuki
  • Hiroyuki Satofuka
  • Kazuma Tomizuka

Best Publications

  • PI3K-Akt pathway: its functions and alterations in human cancer.

    M. Osaki;M. Oshimura;H. Ito

  • Generation of Pluripotent Stem Cells from Neonatal Mouse Testis

    Mito Kanatsu-Shinohara;Kimiko Inoue;Jiyoung Lee;Momoko Yoshimoto

  • Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts

    Yuji Shiba;Toshihito Gomibuchi;Tatsuichiro Seto;Yuko Wada

  • Dicer is essential for formation of the heterochromatin structure in vertebrate cells

    Tatsuo Fukagawa;Masahiro Nogami;Mitsuko Yoshikawa;Masashi Ikeno

  • Loss of imprinting of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith–Wiedemann syndrome and is independent of insulin-like growth factor II imprinting

    Maxwell P. Lee;Michael R. DeBaun;Kohzoh Mitsuya;Heidi L. Galonek

  • LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia

    Clyde Francks;S. Maegawa;J. Laurén;B. S. Abrahams

  • Double trans-chromosomic mice: Maintenance of two individual human chromosome fragments containing Ig heavy and κ loci and expression of fully human antibodies

    Kazuma Tomizuka;Tokuyuki Shinohara;Hitoshi Yoshida;Hiroshi Uejima

  • Functional expression and germline transmission of a human chromosome fragment in chimaeric mice.

    Kazuma Tomizuka;Hitoshi Yoshida;Hiroshi Uejima;Hiroyuki Kugoh

  • Dynamics of epigenetic regulation at the single-cell level

    Lacramioara Bintu;John Yong;Yaron E. Antebi;Kayla McCue

  • Positional cloning of the gene for Nijmegen breakage syndrome.

    Shinya Matsuura;Hiroshi Tauchi;Asako Nakamura;Noriko Kondo

  • Telomere lengths are characteristic in each human individual

    Kaiyo Takubo;Naotaka Izumiyama-Shimomura;Naoko Honma;Motoji Sawabe

  • CTCF-Dependent Chromatin Insulator Is Linked to Epigenetic Remodeling

    Ko Ishihara;Mitsuo Oshimura;Mitsuyoshi Nakao

  • Proteomics-based identification of differentially expressed genes in human gliomas: Down-regulation of SIRT2 gene

    Masaharu Hiratsuka;Toshiaki Inoue;Tosifusa Toda;Narimichi Kimura

  • Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta.

    Daisuke Kobayashi;Ichiro Ieiri;Takeshi Hirota;Hiroshi Takane

  • SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.

    T Inoue;M Hiratsuka;M Osaki;H Yamada

  • Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation

    Wenqiang Yu;Vasudeva Ginjala;Vinod Pant;Igor Chernukhin

  • Transplantation of genetically corrected human iPSC-derived progenitors in mice with limb-girdle muscular dystrophy

    Francesco Saverio Tedesco;Francesco Saverio Tedesco;Mattia F. M. Gerli;Laura Perani;Sara Benedetti

  • Genetic and epigenetic properties of mouse male germline stem cells during long-term culture

    Mito Kanatsu-Shinohara;Narumi Ogonuki;Tomohiko Iwano;Jiyoung Lee;Jiyoung Lee

  • MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression

    Mitsuhiko Osaki;Fumitaka Takeshita;Yui Sugimoto;Nobuyoshi Kosaka

  • Chromosomes and causation of human cancer and leukemia. XXIII. Near-haploidy in acute leukemia.

    Mitsuo Oshimura;Arnold I. Freeman;Avery A. Sandberg

Frequent Co-Authors

Mitsuhiko Osaki
Mitsuhiko Osaki Tottori University
J. Carl Barrett
J. Carl Barrett AstraZeneca (United Kingdom)
Avery A. Sandberg
Avery A. Sandberg Roswell Park Cancer Institute
Takashi Shinohara
Takashi Shinohara Kyoto University
Mito Kanatsu-Shinohara
Mito Kanatsu-Shinohara Kyoto University
Andrew P. Feinberg
Andrew P. Feinberg Johns Hopkins University
Vladimir Larionov
Vladimir Larionov National Institutes of Health
Giulio Cossu
Giulio Cossu University of Manchester
Atsuo Ogura
Atsuo Ogura University of Tsukuba
Dominique Smeets
Dominique Smeets Radboud University

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