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Mitsuhiko Osaki

Mitsuhiko Osaki

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
10285
World Ranking
16640
National Ranking
1191

Overview

Mitsuhiko Osaki is affiliated with Tottori University in Japan. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions also in Medicine.

The main subfields of their work include Molecular Biology, Oncology, Epidemiology, Cancer Research, and Genetics. Their studies focus on topics such as Cancer, Hypoxia, and Metabolism; Angiogenesis and VEGF in Cancer; Cancer Cells and Metastasis; CRISPR and Genetic Engineering; Pluripotent Stem Cells Research; Extracellular vesicles in disease; and Cancer Research and Treatments.

Osaki's recent publications reflect these interests and include the following papers:

  • Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice, 2020, International Journal of Cancer
  • Inflammation-Related Carcinogenesis: Lessons from Animal Models to Clinical Aspects, 2021, Cancers
  • Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis, 2023, Nature Communications
  • AMIGO2 as a novel indicator of liver metastasis in patients with colorectal cancer, 2021, Oncology Letters
  • AMIGO2 contained in cancer cell-derived extracellular vesicles enhances the adhesion of liver endothelial cells to cancer cells, 2022, Scientific Reports

Frequent coauthors associated with Osaki's research include:

  • Futoshi Okada
  • Runa Izutsu
  • Yasuhiro Kazuki
  • Narumi Uno
  • Mitsuo Oshimura

The scientist's work has been published in a variety of venues, with several appearing multiple times. Notable frequent publication venues include:

  • Scientific Reports
  • Molecular Therapy - Nucleic Acids
  • Journal of Gynecology Obstetrics and Human Reproduction
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Research Square (Research Square)

Best Publications

  • PI3K-Akt pathway: its functions and alterations in human cancer.

    M. Osaki;M. Oshimura;H. Ito

  • Systemic Delivery of Synthetic MicroRNA-16 Inhibits the Growth of Metastatic Prostate Tumors via Downregulation of Multiple Cell-cycle Genes

    Fumitaka Takeshita;Lubna Patrawala;Mitsuhiko Osaki;Ryou U. Takahashi

  • IFATS collection : in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury

    Agnieszka Banas;Takumi Teratani;Yusuke Yamamoto;Makoto Tokuhara

  • Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure

    Agnieszka Banas;Takumi Teratani;Yusuke Yamamoto;Makoto Tokuhara

  • SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress.

    T Inoue;M Hiratsuka;M Osaki;H Yamada

  • MicroRNA-143 regulates human osteosarcoma metastasis by regulating matrix metalloprotease-13 expression

    Mitsuhiko Osaki;Fumitaka Takeshita;Yui Sugimoto;Nobuyoshi Kosaka

  • Complete Genetic Correction of iPS Cells From Duchenne Muscular Dystrophy

    Yasuhiro Kazuki;Masaharu Hiratsuka;Masato Takiguchi;Mitsuhiko Osaki

  • The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation

    Toshiaki Inoue;Masaharu Hiratsuka;Mitsuhiko Osaki;Mitsuo Oshimura

  • Aberrant expression of selenoproteins in the progression of colorectal cancer.

    Yoshiyuki Murawaki;Hiroyuki Tsuchiya;Takamasa Kanbe;Kenichi Harada

  • SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

    Yanze Li;Haruka Matsumori;Yuji Nakayama;Mitsuhiko Osaki

  • Expression of p21 (waf1/cip1/sdi1), but not p53 protein, is a factor in the survival of patients with advanced gastric carcinoma

    Yoshihito Gomyo;Mitsuyuki Ikeda;Mitsuhiko Osaki;Shigeru Tatebe

  • Cyclo-oxygenase-1 and -2 expression in human oral mucosa, dysplasias and squamous cell carcinomas and their pathological significance

    Masami Shibata;Isamu Kodani;Mitsuhiko Osaki;Kunio Araki

  • Proteomic identification of differentially‐expressed genes in human gastric carcinomas

    Ryuichi Nishigaki;Mitsuhiko Osaki;Masaharu Hiratsuka;Tosifusa Toda

  • MicroRNAs as biomarkers and therapeutic drugs in human cancer.

    M. Osaki;F. Takeshita;T. Ochiya

  • Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma

    Hideto Iwamoto;Yusuke Kanda;Takehiro Sejima;Mitsuhiko Osaki

  • High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas.

    Kazunori Kidani;Mitsuhiko Osaki;Takayuki Tamura;Kensaku Yamaga

  • Apoptosis in the human allografted kidney. Analysis by terminal deoxynucleotidyl transferase-mediated DUTP-botin nick end labeling.

    Hisao Ito;Noriko Kasagi;Kouhei Shomori;Mitsuhiko Osaki

  • Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45

    Mitsuhiko Osaki;Satoru Kase;Keiko Adachi;Ami Takeda

  • Thymidine Phosphorylase Expression Is Associated with Both Increase of Intratumoral Microvessels and Decrease of Apoptosis in Human Colorectal Carcinomas

    Takahiko Matsuura;Itaru Kuratate;Kazuki Teramachi;Mitsuhiko Osaki

  • Refined human artificial chromosome vectors for gene therapy and animal transgenesis.

    Y Kazuki;H Hoshiya;M Takiguchi;S Abe

Frequent Co-Authors

Futoshi Okada
Futoshi Okada Tottori University
Mitsuo Oshimura
Mitsuo Oshimura Tottori University
Takahiro Ochiya
Takahiro Ochiya Tokyo Medical University
Nobuyoshi Kosaka
Nobuyoshi Kosaka Tokyo Medical University
Shigeaki Ohno
Shigeaki Ohno Hokkaido University
Shigeo Mori
Shigeo Mori University of Tokyo
Thomas Tschernig
Thomas Tschernig Saarland University
Kuan-Teh Jeang
Kuan-Teh Jeang National Institutes of Health
David Mirelman
David Mirelman Weizmann Institute of Science
Atsushi Toyoda
Atsushi Toyoda National Institute of Genetics

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