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Biology and Biochemistry

D-Index
80
Citations
34893
World Ranking
3997
National Ranking
78

Overview

Markus G. Manz is affiliated with the University of Zurich in Switzerland. Their research primarily centers on the field of Medicine, with a particular focus on hematology, immunology, oncology, molecular biology, and genetics. Within these subfields, they have contributed extensively to studies related to hematopoietic stem cell function, immune responses, and cancer dynamics.

The scientist's recent publications include:

  • Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection (2021) in The Journal of Experimental Medicine
  • Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents (2020) in Nature Medicine
  • Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors (2021) in Cell Host & Microbe
  • IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice (2021) in Blood
  • The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support (2021) in Cancer Cell

Repeated contributions have appeared in the following publication venues:

  • Blood
  • HemaSphere
  • Blood Advances
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Leukemia

Frequent collaborators with whom Markus G. Manz has co-authored research include:

  • Bob Löwenberg
  • Christian Pellegrino
  • Gert J. Ossenkoppele
  • Renier Myburgh
  • Jacqueline Cloos

Markus G. Manz's work engages with several main research topics such as:

  • Acute Myeloid Leukemia Research
  • CAR-T cell therapy research
  • Hematopoietic Stem Cell Transplantation
  • Immune Cell Function and Interaction
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Immunotherapy and Immune Responses
  • Cancer Genomics and Diagnostics

The scope of their research covers the regulation and function of hematopoietic stem cells under conditions of disease and aging, mechanisms of immune modulation, and innovative approaches to cancer treatment including cellular therapies. Their studies often integrate molecular biology with clinical implications to investigate hematological malignancies and immune system-related cancers.

Best Publications

  • Development of Monocytes, Macrophages, and Dendritic Cells

    Frederic Geissmann;Markus G. Manz;Steffen Jung;Michael H. Sieweke

  • Granulocyte-Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML

    Catriona H M Jamieson;Laurie E Ailles;Scott J Dylla;Manja Muijtjens

  • Development of a human adaptive immune system in cord blood cell-transplanted mice.

    Elisabetta Traggiai;Laurie Chicha;Luca Mazzucchelli;Lucio Bronz

  • Biology of hematopoietic stem cells and progenitors: implications for clinical application.

    Motonari Kondo;Amy J. Wagers;Markus G. Manz;Susan S. Prohaska

  • Langerhans cells renew in the skin throughout life under steady-state conditions

    Miriam Merad;Markus G. Manz;Holger Karsunky;Amy Wagers

  • Identification of clonogenic common Flt3 + M-CSFR + plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow

    Nobuyuki Onai;Aya Obata-Onai;Michael A Schmid;Toshiaki Ohteki

  • Development and function of human innate immune cells in a humanized mouse model

    Anthony Rongvaux;Tim Willinger;Jan Martinek;Till Strowig

  • Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo

    Holger Karsunky;Miriam Merad;Antonio Cozzio;Irving L. Weissman

  • Prospective isolation of human clonogenic common myeloid progenitors

    Markus G. Manz;Toshihiro Miyamoto;Koichi Akashi;Irving L. Weissman

  • Molecular Minimal Residual Disease in Acute Myeloid Leukemia

    Mojca Jongen-Lavrencic;Tim Grob;Diana Hanekamp;François G Kavelaars

  • Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal

    Eric M. Pietras;Cristina Mirantes-Barbeito;Sarah Fong;Dirk Loeffler

  • Dendritic cell potentials of early lymphoid and myeloid progenitors.

    Markus G. Manz;David Traver;David Traver;Toshihiro Miyamoto;Toshihiro Miyamoto;Irving L. Weissman;Irving L. Weissman

  • Development of CD8α-Positive Dendritic Cells from a Common Myeloid Progenitor

    David Traver;Koichi Akashi;Markus Manz;Miriam Merad

  • Dendritic cell homeostasis

    Miriam Merad;Markus G. Manz

  • BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups

    Marie-Luise Berres;Karen Phaik Har Lim;Tricia Peters;Jeremy Price

  • Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease

    Miriam Merad;Petra Hoffmann;Petra Hoffmann;Erik Ranheim;Sarah Slaymaker

  • Demand-adapted regulation of early hematopoiesis in infection and inflammation

    Hitoshi Takizawa;Steffen Boettcher;Markus G. Manz

  • Human Hemato-Lymphoid System Mice: Current Use and Future Potential for Medicine

    Anthony Rongvaux;Hitoshi Takizawa;Till Strowig;Tim Willinger

  • Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

    Hitoshi Takizawa;Roland R. Regoes;Chandra S. Boddupalli;Sebastian Bonhoeffer

  • BIOLOGY OF HEMATOPOIETIC STEM CELLS AND PROGENITORS: Implications for

    Motonari Kondo;Amy J. Wagers;Markus G. Manz;Susan S. Prohaska

Frequent Co-Authors

Richard A. Flavell
Richard A. Flavell Yale University
Bob Löwenberg
Bob Löwenberg Erasmus MC
Till Strowig
Till Strowig Helmholtz Centre for Infection Research
Jakob Passweg
Jakob Passweg University Hospital of Basel
Irving L. Weissman
Irving L. Weissman Stanford University
Peter J. M. Valk
Peter J. M. Valk Erasmus University Rotterdam
Miriam Merad
Miriam Merad Icahn School of Medicine at Mount Sinai
Mathias Heikenwalder
Mathias Heikenwalder German Cancer Research Center
Dario Neri
Dario Neri Philogen (Italy)
Madhav V. Dhodapkar
Madhav V. Dhodapkar Emory University

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