World's Best Scientists 2026 revealed!
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Best Female Scientists
2025
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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Best Female Scientists

D-Index
127
Citations
61474
World Ranking
399
National Ranking
9

Biology and Biochemistry

D-Index
128
Citations
63332
World Ranking
451
National Ranking
10

Medicine

D-Index
128
Citations
63350
World Ranking
2703
National Ranking
105

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2023 - Research.com Medicine in Canada Leader Award
  • 2022 - Research.com Biology and Biochemistry in Canada Leader Award
  • 2015 - Fellow of the Royal Society of Edinburgh
  • 1994 - Fellow of the Royal Society of Canada Academy of Science

Overview

Connie J. Eaves was affiliated with the University of British Columbia in Canada and contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. Their work focused on several subfields including molecular biology, hematology, immunology, genetics, and oncology.

The scientist's research topics covered areas such as chronic myeloid leukemia treatments, hematopoietic stem cell transplantation, acute myeloid leukemia research, epigenetics and DNA methylation, single-cell and spatial transcriptomics, T-cell and B-cell immunology, and cancer genomics and diagnostics.

Frequent publication venues included:

  • Experimental Hematology
  • Blood
  • Cancer Research
  • Leukemia
  • bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors working with Connie J. Eaves were:

  • Martin Hirst
  • Fangwu Wang
  • Susanna Tan
  • Colin A. Hammond
  • Margarita MacAldaz

Selected recent papers by this scientist include:

  • Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis, 2022, The Journal of Cell Biology
  • The miR-185/PAK6 axis predicts therapy response and regulates survival of drug-resistant leukemic stem cells in CML, 2020, Blood
  • Altered microRNA expression links IL6 and TNF-induced inflammaging with myeloid malignancy in humans and mice, 2020, Blood
  • Modification of BRCA1-associated breast cancer risk by HMMR overexpression, 2022, Nature Communications
  • Mammary epithelial cells have lineage-rooted metabolic identities, 2021, Nature Metabolism

Throughout their career, Eaves received recognition including being named a Fellow of the Royal Society of Canada in 1994 under the Academy of Science, and a Fellow of the Royal Society of Edinburgh in 2015.

Best Publications

  • Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

    Michael F. Clarke;John E. Dick;Peter B. Dirks;Connie J. Eaves

  • The clonal and mutational evolution spectrum of primary triple-negative breast cancers

    Sohrab P. Shah;Andrew Roth;Rodrigo Goya;Arusha Oloumi

  • Purification and unique properties of mammary epithelial stem cells

    John Stingl;Peter Eirew;Ian Ricketson;Mark Shackleton

  • Cancer stem cells: an evolving concept

    Long V. Nguyen;Robert Vanner;Peter Dirks;Connie J. Eaves

  • Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells.

    Ryan D Morin;Michael D O'Connor;Malachi Griffith;Florian Kuchenbauer

  • Characterization and Partial Purification of Human Marrow Cells Capable of Initiating Long-Term Hematopoiesis In Vitro

    Heather J. Sutherland;Connie J. Eaves;Allen C. Eaves;Wieslawa Dragowska

  • Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

    Heather J. Sutherland;Peter M. Lansdorp;Don H. Henkelman;Allen C. Eaves

  • Cancer stem cell definitions and terminology: the devil is in the details

    Peter Valent;Dominique Bonnet;Ruggero De Maria;Tsvee Lapidot

  • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

    G Sauvageau;U Thorsteinsdottir;C J Eaves;H J Lawrence

  • Long-term propagation of distinct hematopoietic differentiation programs in vivo.

    Brad Dykstra;Brad Dykstra;David Kent;David Kent;Michelle Bowie;Michelle Bowie;Lindsay McCaffrey

  • Correction of Sickle Cell Disease in Transgenic Mouse Models by Gene Therapy

    Robert Pawliuk;Karen A. Westerman;Mary E. Fabry;Emmanuel Payen

  • Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic–scid/scid mice

    E. Conneally;J. Cashman;A. Petzer;C. Eaves

  • Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

    Peter Eirew;Peter Eirew;Adi Steif;Adi Steif;Jaswinder Khattra;Jaswinder Khattra;Gavin Ha;Gavin Ha

  • Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines

    J S Greenberger;M A Sakakeeny;R K Humphries;C J Eaves

  • Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

    G Sauvageau;P M Lansdorp;C J Eaves;D E Hogge

  • Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Marko Škrtić;Shrivani Sriskanthadevan;Bozhena Jhas;Marinella Gebbia

  • Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia.

    Tessa Holyoake;Xiaoyan Jiang;Connie Eaves;Allen Eaves

  • Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

    Iman Fares;Jalila Chagraoui;Yves Gareau;Stéphane Gingras

  • Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin

    Kevin G. Leong;Kyle Niessen;Iva Kulic;Afshin Raouf

  • Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

    S J Szilvassy;R K Humphries;P M Lansdorp;A C Eaves

Frequent Co-Authors

Allen C. Eaves
Allen C. Eaves Stemcell Technologies
Xiaoyan Jiang
Xiaoyan Jiang University of British Columbia
Martin Hirst
Martin Hirst University of British Columbia
Peter M. Lansdorp
Peter M. Lansdorp University of British Columbia
R. Keith Humphries
R. Keith Humphries University of British Columbia
Samuel Aparicio
Samuel Aparicio University of British Columbia
Tessa L. Holyoake
Tessa L. Holyoake University of Glasgow
Marco A. Marra
Marco A. Marra University of British Columbia
Donna E. Hogge
Donna E. Hogge University of British Columbia
Ali G. Turhan
Ali G. Turhan University of Paris-Saclay

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