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Sten Eirik W. Jacobsen

Sten Eirik W. Jacobsen

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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
97
Citations
36581
World Ranking
1744
National Ranking
111

Medicine

D-Index
97
Citations
36581
World Ranking
9247
National Ranking
899

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award

Overview

Sten Eirik W. Jacobsen is affiliated with the University of Oxford in the United Kingdom. Their research primarily focuses on fields within medicine and biochemistry, genetics, and molecular biology. Within these broader domains, Jacobsen's work is concentrated on hematology, immunology, molecular biology, genetics, and cancer research.

The scientist's work covers several main topics, including acute myeloid leukemia research, hematopoietic stem cell transplantation, single-cell and spatial transcriptomics, cancer genomics and diagnostics, immune cell function and interaction, T-cell and B-cell immunology, and platelet disorders and treatments.

Jacobsen has contributed to various scientific publications, notably in venues such as Blood, bioRxiv (Cold Spring Harbor Laboratory), Experimental Hematology, Nature Communications, and Cell Research. The research presence in these journals indicates a focus on hematological and molecular biology-related studies.

Among recent papers, several highlight different aspects of cellular behavior, immune function, and cancer biology:

  • Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution, 2023, Nature Genetics
  • Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart, 2021, Development
  • Chemotherapy induces canalization of cell state in childhood B-cell precursor acute lymphoblastic leukemia, 2021, Nature Cancer
  • Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice, 2021, Nature Communications
  • The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition, 2021, Cell Reports

Frequent collaborators include Petter Woll, Tetsuichi Yoshizato, Joana Carrelha, Gunilla Walldin, and Francesca Grasso, with varying degrees of collaboration counts indicating substantial joint work over time.

Best Publications

  • A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

    Christian Schulz;Elisa Gomez Perdiguero;Laurent Chorro;Heather Szabo-Rogers

  • Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment

    Jörgen Adolfsson;Robert Månsson;Natalija Buza-Vidas;Anne Hultquist

  • Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation.

    Jens Martin Nygren;Stefan Jovinge;Martin Breitbach;Petter Säwén

  • c-kit Ligand and Flt3 Ligand: Stem/Progenitor Cell Factors With Overlapping Yet Distinct Activities

    Stewart D. Lyman;Sten Eirik W. Jacobsen

  • Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

    Jörgen Adolfsson;Ole Johan Borge;David Bryder;Kim Theilgaard-Mönch

  • Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia

    Nicolas Goardon;Emanuele Marchi;Ann Atzberger;Lynn Quek

  • Potential risks of bone marrow cell transplantation into infarcted hearts

    Martin Breitbach;Toktam Bostani;Wilhelm Roell;Ying Xia

  • The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

    Monika Mortensen;Elizabeth Jane Soilleux;Gordana Djordjevic;Rebecca Tripp

  • Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

    Alejandra Sanjuan-Pla;Iain C. Macaulay;Christina T. Jensen;Petter S. Woll

  • Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

    Hong Qian;Natalija Buza-Vidas;Natalija Buza-Vidas;Craig D. Hyland;Christina T. Jensen;Christina T. Jensen

  • Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

    K Hestdal;F W Ruscetti;J N Ihle;S E Jacobsen

  • Identification of Lin – Sca1 + kit + CD34 + Flt3 – short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients

    Liping Yang;David Bryder;Jörgen Adolfsson;Jens Martin Nygren

  • Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block

    Peggy Kirstetter;Kristina Anderson;Bo T Porse;Sten Eirik W Jacobsen

  • Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis.

    Robert E Iosif;Christine T Ekdahl;Henrik Ahlenius;Cornelis J H Pronk

  • DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

    Ann-Marie Bröske;Lena Vockentanz;Shabnam Kharazi;Matthew R Huska

  • Distinct patterns of hematopoietic stem cell involvement in acute lymphoblastic leukemia

    Anders Castor;Lars Nilsson;Ingbritt Astrand-Grundström;Miranda Buitenhuis

  • Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke.

    Pär Thored;Ursula Heldmann;Walace Gomes-Leal;Walace Gomes-Leal;Ramiro Gisler

  • Engraftment of engineered ES cell–derived cardiomyocytes but not BM cells restores contractile function to the infarcted myocardium

    Eugen Kolossov;Toktam Bostani;Wilhelm Roell;Martin Breitbach

  • Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors

    Robert Månsson;Anne Hultquist;Sidinh Luc;Liping Yang

  • Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia

    Alice Giustacchini;Supat Thongjuea;Nikolaos Barkas;Petter S Woll

Frequent Co-Authors

Claus Nerlov
Claus Nerlov University of Oxford
Eva Hellström-Lindberg
Eva Hellström-Lindberg Karolinska University Hospital
David Bryder
David Bryder Lund University
Mikael Sigvardsson
Mikael Sigvardsson Lund University
Lennart Nilsson
Lennart Nilsson Karolinska Institute
Tariq Enver
Tariq Enver University College London
Paresh Vyas
Paresh Vyas University of Oxford
Francis W. Ruscetti
Francis W. Ruscetti National Institutes of Health
Peter Hokland
Peter Hokland Aarhus University
Erlend B. Smeland
Erlend B. Smeland Oslo University Hospital

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