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Mikael Sigvardsson

Mikael Sigvardsson

D-Index & Metrics

Molecular Biology

D-Index
59
Citations
14391
World Ranking
2009
National Ranking
31

Overview

Mikael Sigvardsson is affiliated with Lund University in Sweden. Their research spans multiple fields including Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these broad areas, their work covers subfields such as Immunology, Molecular Biology, Hematology, Public Health, Environmental and Occupational Health, and Oncology.

Their contributions focus on main topics including:

  • Immune Cell Function and Interaction
  • Acute Lymphoblastic Leukemia research
  • T-cell and B-cell Immunology
  • Acute Myeloid Leukemia Research
  • CAR-T cell therapy research
  • IL-33, ST2, and ILC Pathways
  • Genomics and Chromatin Dynamics

Sigvardsson has published research papers in several peer-reviewed journals. Notable recent publications include:

  • "13q12.2 deletions in acute lymphoblastic leukemia lead to upregulation of FLT3 through enhancer hijacking," 2020, Blood
  • "IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage," 2022, Immunity
  • "EBF1 and PAX5 control pro-B cell expansion via opposing regulation of the Myc gene," 2021, Blood
  • "The transcription factor BCL-6 controls early development of innate-like T cells," 2020, Nature Immunology
  • "ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development," 2020, The Journal of Immunology

Their work commonly appears in venues such as The Journal of Immunology, Blood, Nature Immunology, Haematologica, and Frontiers in Immunology. The Journal of Immunology stands out as a frequent publication venue with seven publications.

Collaborations form an important aspect of Sigvardsson's research. Frequent coauthors include:

  • Jonas Ungerbäck
  • Barbara L. Kee
  • Johanna Tingvall-Gustafsson
  • Elizabeth T. Bartom
  • Christina T. Jensen

In addition to journal articles, Sigvardsson has contributed to book publications. One known book is titled Molecular Switches of the Immune System: The E Protein/Id Axis in Hematopoietic Development and Function, published by Frontiers Media in 2022.

Best Publications

  • Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment

    Jörgen Adolfsson;Robert Månsson;Natalija Buza-Vidas;Anne Hultquist

  • Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

    Isabel Beerman;Deepta Bhattacharya;Sasan Zandi;Mikael Sigvardsson

  • Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

    Cornelis J.H. Pronk;Derrick J. Rossi;Robert Månsson;Joanne L. Attema

  • Identification of Lin – Sca1 + kit + CD34 + Flt3 – short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients

    Liping Yang;David Bryder;Jörgen Adolfsson;Jens Martin Nygren

  • A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate

    Yin C Lin;Suchit Jhunjhunwala;Christopher Benner;Sven Heinz

  • Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

    Ross M Okamura;Mikael Sigvardsson;Juan Galceran;Sjef Verbeek

  • Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors

    Robert Månsson;Anne Hultquist;Sidinh Luc;Liping Yang

  • Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells

    Nicola Guzzi;Maciej Cieśla;Phuong Cao Thi Ngoc;Stefan Lang

  • EBF and E47 Collaborate to Induce Expression of the Endogenous Immunoglobulin Surrogate Light Chain Genes

    Mikael Sigvardsson;Mary O'Riordan;Rudolf Grosschedl

  • Critical role for Ebf1 and Ebf2 in the adipogenic transcriptional cascade.

    Maria A Jimenez;Peter Akerblad;Mikael Sigvardsson;Evan D Rosen;Evan D Rosen

  • Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

    Stephan Mathas;Martin Janz;Martin Janz;Franziska Hummel;Michael Hummel

  • E2A Proteins Promote Development of Lymphoid-Primed Multipotent Progenitors

    Sheila Dias;Robert Månsson;Sandeep Gurbuxani;Mikael Sigvardsson

  • Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging.

    Gudmundur L. Norddahl;Cornelis J. Pronk;Martin Wahlestedt;Gerd Sten

  • Complementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesis.

    Ewa Sitnicka;Cord Brakebusch;Inga-Lill Martensson;Marcus Svensson

  • EBF1 Is Essential for B-Lineage Priming and Establishment of a Transcription Factor Network in Common Lymphoid Progenitors

    Sasan Zandi;Robert Mansson;Panagiotis Tsapogas;Jenny Zetterblad

  • Induction of ID2 Expression by Hypoxia-inducible Factor-1 A ROLE IN DEDIFFERENTIATION OF HYPOXIC NEUROBLASTOMA CELLS

    Tobias Löfstedt;Annika Jögi;Mikael Sigvardsson;Katarina Gradin

  • Primary mesenchymal stem and progenitor cells from bone marrow lack expression of CD44 protein.

    Hong Qian;Hong Qian;Katarina Le Blanc;Mikael Sigvardsson

  • Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon.

    Pontus C. Holm;Michael T. Mader;Nicole Haubst;Andrea Wizenmann

  • Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia

    Rajesh Somasundaram;Mahadesh A. J. Prasad;Jonas Ungerbäck;Mikael Sigvardsson

  • Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.

    Holger Weishaupt;Mikael Sigvardsson;Mikael Sigvardsson;Joanne L. Attema

Frequent Co-Authors

David Bryder
David Bryder Lund University
Sten Eirik W. Jacobsen
Sten Eirik W. Jacobsen University of Oxford
Tomas Leanderson
Tomas Leanderson Lund University
James Hagman
James Hagman University of Colorado Anschutz Medical Campus
William W. Agace
William W. Agace University of Copenhagen
Eva Hellström-Lindberg
Eva Hellström-Lindberg Karolinska University Hospital
Thoas Fioretos
Thoas Fioretos Lund University
Cornelis Murre
Cornelis Murre University of California, San Diego
Rudolf Grosschedl
Rudolf Grosschedl Max Planck Society
Bertil Johansson
Bertil Johansson Lund University

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