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Biology and Biochemistry
Australia
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
93
Citations
40173
World Ranking
2070
National Ranking
45

Medicine

D-Index
93
Citations
40162
World Ranking
10738
National Ranking
333

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Australia Leader Award
  • 2019 - Fellow of the Australian Academy of Science
  • 2015 - Fellow of the Australian Academy of Health and Medical Science

Overview

Warren S. Alexander is affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their research spans multiple areas within medicine, with significant contributions to immunology, hematology, molecular biology, oncology, and genetics. Their work encompasses both basic and translational science, focusing on mechanisms underlying immune cell functions, hematopoietic stem cell biology, and disease processes involving inflammation and cancer.

Alexander's publications have appeared frequently in prominent scientific journals. Key venues featuring their work include:

  • Nature Communications
  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Experimental Medicine
  • Nature Immunology

Their recent papers cover various aspects of cell death, hematopoiesis, and immune regulation. Notable publications include:

  • A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction (2020, Nature Communications)
  • Membrane budding is a major mechanism of in vivo platelet biogenesis (2020, The Journal of Experimental Medicine)
  • The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal (2021, Blood)
  • Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice (2020, Cell Death and Differentiation)
  • An Erg-driven transcriptional program controls B cell lymphopoiesis (2020, Nature Communications)

Alexander frequently collaborates with several researchers. Regular coauthors include:

  • Andrew J. Kueh
  • Jeffrey J. Babon
  • Alexandra L. Garnham
  • Ashley P. Ng
  • Pradnya Gangatirkar

Their main fields of study reflect a strong emphasis on medicine and life sciences:

  • Medicine
  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Within these broader fields, Alexander's work focuses on specific subfields including:

  • Immunology
  • Hematology
  • Molecular Biology
  • Oncology
  • Genetics

Their research topics incorporate critical areas such as:

  • Immune Cell Function and Interaction
  • Platelet Disorders and Treatments
  • Immunotherapy and Immune Responses
  • Cytokine Signaling Pathways and Interactions
  • Hematopoietic Stem Cell Transplantation
  • Myeloproliferative Neoplasms: Diagnosis and Treatment
  • Interferon and Immune Responses

Alexander has received recognition for their contribution to science, including being named a Fellow of the Australian Academy of Health and Medical Science in 2015 and a Fellow of the Australian Academy of Science in 2019.

Best Publications

  • A family of cytokine-inducible inhibitors of signalling

    Robyn Starr;Tracy A. Willson;Elizabeth M. Viney;Leecia J. L. Murray

  • The c- myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

    J. M. Adams;A. W. Harris;C. A. Pinkert;L. M. Corcoran

  • The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

    James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

  • The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response.

    Warren S. Alexander;Douglas J. Hilton

  • SOCS3 negatively regulates IL-6 signaling in vivo.

    Ben A Croker;Danielle L Krebs;Jian-Guo Zhang;Sam Wormald

  • Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells.

    Timothy Gainsford;Tracy A. Willson;Donald Metcalf;Emanuela Handman

  • SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

    Warren S Alexander;Robyn Starr;Robyn Starr;Jennifer E Fenner;Clare L Scott;Clare L Scott

  • Twenty proteins containing a C-terminal SOCS box form five structural classes

    Douglas J. Hilton;Rachael T. Richardson;Warren S. Alexander;Elizabeth M. Viney

  • Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression

    Belinda Phipson;Stanley Lee;Ian J. Majewski;Warren S. Alexander

  • Suppressors of cytokine signalling (SOCS) in the immune system.

    Warren S. Alexander

  • The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

    Jian Guo Zhang;Alison Farley;Sandra E. Nicholson;Tracy A. Willson

  • Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice

    Ygal Haupt;Warren S. Alexander;Gina Barri;S. Peter Klinken

  • Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-Mpl

    Warren S. Alexander;Andrew W. Roberts;Nicos A. Nicola;Ruili Li

  • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

    Kate E. Lawlor;Nufail Khan;Alison Mildenhall;Motti Gerlic

  • Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells

    Hong Qian;Natalija Buza-Vidas;Natalija Buza-Vidas;Craig D. Hyland;Christina T. Jensen;Christina T. Jensen

  • RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

    James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

  • Gigantism in mice lacking suppressor of cytokine signalling-2

    Donald Metcalf;Christopher J. Greenhalgh;Elizabeth Viney;Tracy A. Willson

  • The SOCS box: a tale of destruction and degradation

    Benjamin T Kile;Brenda A Schulman;Warren S Alexander;Nicos A Nicola

  • Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

    Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

  • Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

    Sandra E. Nicholson;Tracy A. Willson;Alison Farley;Robyn Starr

Frequent Co-Authors

Douglas J. Hilton
Douglas J. Hilton Walter and Eliza Hall Institute of Medical Research
Donald Metcalf
Donald Metcalf Walter and Eliza Hall Institute of Medical Research
Nicos A. Nicola
Nicos A. Nicola Walter and Eliza Hall Institute of Medical Research
Benjamin T. Kile
Benjamin T. Kile University of Adelaide
Andrew W. Roberts
Andrew W. Roberts Walter and Eliza Hall Institute of Medical Research
Jian-Guo Zhang
Jian-Guo Zhang Beijing Institute for Brain Disorders
Tracy A. Willson
Tracy A. Willson Walter and Eliza Hall Institute of Medical Research
Gordon K. Smyth
Gordon K. Smyth Walter and Eliza Hall Institute of Medical Research
John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research

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