Jeffrey J. Babon

Overview

Best Publications

• The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

  James M. Murphy;Peter E. Czabotar;Peter E. Czabotar;Joanne M. Hildebrand;Joanne M. Hildebrand;Isabelle S. Lucet

  1187
  Citations

• The molecular details of cytokine signaling via the JAK/STAT pathway.

  Rhiannon Morris;Nadia J. Kershaw;Nadia J. Kershaw;Jeffrey J. Babon;Jeffrey J. Babon

  666
  Citations

• Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

  Joanne M. Hildebrand;Maria C. Tanzer;Isabelle S. Lucet;Isabelle S. Lucet;Samuel N. Young

  553
  Citations

• Leukemia inhibitory factor (LIF).

  Nicos A. Nicola;Nicos A. Nicola;Jeffrey J. Babon;Jeffrey J. Babon

  434
  Citations

• CIS is a potent checkpoint in NK cell–mediated tumor immunity

  Rebecca B. Delconte;Tatiana B Kolesnik;Laura F. Dagley;Laura F. Dagley;Jai Rautela;Jai Rautela

  394
  Citations

• The molecular basis of JAK/STAT inhibition by SOCS1

  Nicholas P. D. Liau;Nicholas P. D. Liau;Artem Laktyushin;Artem Laktyushin;Isabelle S. Lucet;Isabelle S. Lucet;James M. Murphy;James M. Murphy

  360
  Citations

• The molecular regulation of Janus kinase (JAK) activation.

  Jeffrey J. Babon;Jeffrey J. Babon;Isabelle S. Lucet;Isabelle S. Lucet;James M. Murphy;James M. Murphy;Nicos A. Nicola;Nicos A. Nicola

  332
  Citations

• Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

  Jeffrey J Babon;Nadia J Kershaw;Nadia J Kershaw;James M Murphy;James M Murphy;Leila N Varghese;Leila N Varghese

  311
  Citations

• SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

  Nadia J Kershaw;James M Murphy;James M Murphy;Nicholas P D Liau;Nicholas P D Liau;Leila N Varghese;Leila N Varghese

  300
  Citations

• A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.

  James M. Murphy;James M. Murphy;Qingwei Zhang;Samuel N. Young;Michael L. Reese

  280
  Citations

• Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections.

  Xavier Lauth;Jeffrey J. Babon;Jason A. Stannard;Satendra Singh

  264
  Citations

• Suppression of cytokine signaling: The SOCS perspective

  Edmond M. Linossi;Jeffrey J. Babon;Jeffrey J. Babon;Douglas J. Hilton;Douglas J. Hilton;Sandra E. Nicholson;Sandra E. Nicholson

  222
  Citations

• Inhibition of IL-6 family cytokines by SOCS3.

  Jeffrey J. Babon;Leila N. Varghese;Nicos A. Nicola

  212
  Citations

• The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability

  Jeffrey J. Babon;Edward J. McManus;Shenggen Yao;David P. DeSouza

  187
  Citations

• Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein.

  Caterina Alfano;Domenico Sanfelice;Jeff Babon;Geoff Kelly

  182
  Citations

• Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

  Akshay D'Cruz;Jeffrey Babon;Jeffrey Babon;Raymond Stanley Norton;Nicos A Nicola;Nicos A Nicola

  160
  Citations

• The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.

  Jeffrey J Babon;Jennifer K Sabo;Jian-Guo Zhang;Nicos A Nicola

  159
  Citations

• The biology and mechanism of action of suppressor of cytokine signaling 3.

  Jeffrey J Babon;Nicos A Nicola

  138
  Citations

• Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element.

  Amanda Jacks;Jeff Babon;Geoff Kelly;Ioannis Manolaridis

  129
  Citations

• The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

  Jeffrey J Babon;Jennifer K Sabo;Alfreda Soetopo;Shenggen Yao

  128
  Citations