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Molecular Biology

D-Index
93
Citations
40946
World Ranking
668
National Ranking
18

Overview

David L. Vaux is a researcher affiliated with the Walter and Eliza Hall Institute of Medical Research in Australia. Their scholarly work centers predominantly on biochemistry, genetics, and molecular biology, with additional focus areas in medicine. A significant portion of their research is situated within subfields such as molecular biology, epidemiology, oncology, genetics, and computational theory and mathematics.

The primary topics that characterize their studies include:

  • Cell death mechanisms and regulation
  • RNA interference and gene delivery
  • CRISPR and genetic engineering
  • Pluripotent stem cells research
  • Virus-based gene therapy research
  • Autophagy in disease and therapy
  • PARP inhibition in cancer therapy

David L. Vaux has contributed to several research papers published in notable venues. These include:

  • "Cell Death in the Origin and Treatment of Cancer," 2020, Molecular Cell
  • "Targeting triple-negative breast cancers with the Smac-mimetic birinapant," 2020, Cell Death and Differentiation
  • "Glucocorticoids can induce BIM to trigger apoptosis in the absence of BAX and BAK1," 2020, Cell Death and Disease
  • "The BCL-2 protein family: from discovery to drug development," 2025, Cell Death and Differentiation
  • "Easy Multiple Sequential CRISPR/Cas9 Knockouts in Cell Lines Using a Cre/LoxP Re-Cyclable Vector," 2021, Research Square (Research Square)

Their collaborative network includes frequent co-authors such as Andreas Strasser, Nima Etemadi, Dong Li, Margaret C. Cummings, and Ruth M. Kluck.

David L. Vaux's research outputs frequently appear in prominent scientific journals, with multiple publications in Cell Death and Differentiation, and additional works in Molecular Cell, Cell Death and Disease, Research Square, and bioRxiv.

Best Publications

  • Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.

    David L. Vaux;Suzanne Cory;Jerry M. Adams

  • Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

    Anne M Verhagen;Paul G Ekert;Paul G Ekert;Miha Pakusch;John Silke

  • CELL DEATH IN DEVELOPMENT

    David L Vaux;Stanley J Korsmeyer

  • The molecular biology of apoptosis.

    D L Vaux;A Strasser

  • IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

    James E. Vince;W. Wei-Lynn Wong;Nufail Khan;Rebecca Feltham

  • Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease

    Andreas Strasser;Senga Whittingham;David L. Vaux;Mary L. Bath

  • Error bars in experimental biology

    Geoffrey David. Cumming;Fiona Margaret. Fidler;David. Vaux

  • An evolutionary perspective on apoptosis.

    David L. Vaux;Georg Haecker;Andreas Strasser

  • Toward an understanding of the molecular mechanisms of physiological cell death.

    David L. Vaux

  • Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2

    David L. Vaux;Irving L. Weissman;Stuart K. Kim

  • HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

    Anne M Verhagen;John Silke;Paul G Ekert;Paul G Ekert;Miha Pakusch

  • IAPs, RINGs and ubiquitylation

    David L. Vaux;John Silke

  • Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies

    Alex R. D. Delbridge;Stephanie Grabow;Andreas Strasser;David L. Vaux

  • Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

    Vanessa S. Marsden;Liam O'Connor;Liam O'Connor;Lorraine A. O'Reilly;John Silke

  • Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype

    Anthony G. Uren;Lee Lee Wong;Miha Pakusch;Kerry J. Fowler

  • Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

    Anthony G. Uren;Miha Pakusch;Christine J. Hawkins;Kirsten L. Puls

  • RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

    Kate E. Lawlor;Nufail Khan;Alison Mildenhall;Motti Gerlic

  • RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis.

    James A Rickard;James A Rickard;Joanne A O'Donnell;Joanne A O'Donnell;Joseph M Evans;Joseph M Evans;Najoua Lalaoui;Najoua Lalaoui

  • Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.

    Anne M Verhagen;Elizabeth J Coulson;David L Vaux

  • Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts.

    Janette Allison;Harry M. Georgiou;Andreas Strasser;David L. Vaux

Frequent Co-Authors

John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Paul G Ekert
Paul G Ekert University of New South Wales
James E. Vince
James E. Vince Walter and Eliza Hall Institute of Medical Research
Andreas Strasser
Andreas Strasser Walter and Eliza Hall Institute of Medical Research
Kate E. Lawlor
Kate E. Lawlor Hudson Institute of Medical Research
James M. Murphy
James M. Murphy Walter and Eliza Hall Institute of Medical Research
Warren S. Alexander
Warren S. Alexander Walter and Eliza Hall Institute of Medical Research
Jerry M. Adams
Jerry M. Adams Walter and Eliza Hall Institute of Medical Research
Lorraine A. O'Reilly
Lorraine A. O'Reilly Walter and Eliza Hall Institute of Medical Research
Suzanne Cory
Suzanne Cory Walter and Eliza Hall Institute of Medical Research

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