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Bryan R. Cullen

Bryan R. Cullen

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Microbiology
USA
2026
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Molecular Biology
USA
2026

D-Index & Metrics

Microbiology

D-Index
143
Citations
71407
World Ranking
45
National Ranking
23

Molecular Biology

D-Index
142
Citations
70913
World Ranking
113
National Ranking
75

Medicine

D-Index
143
Citations
71371
World Ranking
1519
National Ranking
882

Research.com Recognitions

  • 2026 - Research.com Microbiology in United States Leader Award
  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Microbiology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2011 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Bryan R. Cullen is affiliated with Duke University in the United States. Their research spans primarily biochemistry, genetics, and molecular biology, with contributions also within medicine. Key subfields include molecular biology, virology, immunology, cardiology and cardiovascular medicine, and genetics.

The scientist has extensively investigated topics related to RNA research and splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, HIV research and treatment, viral infections and immunology, T-cell and retrovirus studies, as well as cancer-related molecular mechanisms.

Recent publications demonstrate a focus on RNA biology and viral replication, with papers published from 2020 through 2023. Notable works include:

  • Acetylation of Cytidine Residues Boosts HIV-1 Gene Expression by Increasing Viral RNA Stability, 2020, Cell Host & Microbe
  • Epigenetic and epitranscriptomic regulation of viral replication, 2020, Nature Reviews Microbiology
  • Epitranscriptomic addition of m 6 A regulates HIV-1 RNA stability and alternative splicing, 2021, Genes & Development
  • RNA conformational propensities determine cellular activity, 2023, Nature
  • Probing RNA Conformational Equilibria within the Functional Cellular Context, 2020, Cell Reports

Frequent co-authors collaborating with Bryan R. Cullen include:

  • Hal P. Bogerd
  • Kevin Tsai
  • Laura R. Ganser
  • Hashim M. Al-Hashimi
  • Cecilia Martínez-Campos

The majority of Cullen's publications have appeared in venues such as bioRxiv (Cold Spring Harbor Laboratory), UNC Libraries, Nature, RNA, and Cell Host & Microbe. These platforms reflect a consistent output in molecular biology and virology research.

Professional recognition includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2011.

Best Publications

  • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

    Rui Yi;Yi Qin;Ian G. Macara;Bryan R. Cullen

  • Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs

    Xuezhong Cai;Curt H. Hagedorn;Bryan R. Cullen

  • The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA.

    Michael H. Malim;Joachim Hauber;Shu-Yun Le;Jacob V. Maizel

  • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms

    Yan Zeng;Rui Yi;Bryan R. Cullen

  • Both Natural and Designed Micro RNAs Can Inhibit the Expression of Cognate mRNAs When Expressed in Human Cells

    Yan Zeng;Eric J Wagner;Bryan R Cullen;Bryan R Cullen

  • Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1

    SS Hwang;TJ Boyle;HK Lyerly;BR Cullen;BR Cullen

  • Use of eukaryotic expression technology in the functional analysis of cloned genes

    Bryan R. Cullen

  • Transcription and Processing of Human microRNA Precursors

    Bryan R. Cullen

  • Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev function

    Michael H. Malim;Sabine Böhnlein;Joachim Hauber;Bryan R. Cullen

  • Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells.

    Joel Berger;Joachim Hauber;Regina Hauber;Reinhard Geiger

  • Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism

    Bryan R. Cullen

  • MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs

    Jennifer Lin Umbach;Martha F. Kramer;Igor Jurak;Heather W. Karnowski

  • Sequence requirements for micro RNA processing and function in human cells.

    Yan Zeng;Bryan R. Cullen

  • Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.

    Yan Zeng;Rui Yi;Bryan R Cullen;Bryan R Cullen

  • Viruses, microRNAs, and host interactions.

    Rebecca L. Skalsky;Bryan R. Cullen

  • Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells

    Xuezhong Cai;Shihua Lu;Zhihong Zhang;Carlos M. Gonzalez

  • The imprinted H19 noncoding RNA is a primary microRNA precursor

    Xuezhong Cai;Bryan R. Cullen

  • Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.

    Michael Sharon;Richard D. Klausner;Bryan R. Cullen;Richard Chizzonite

  • A viral microRNA functions as an orthologue of cellular miR-155

    Eva Gottwein;Neelanjan Mukherjee;Christoph Sachse;Corina Frenzel

  • Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed.

    Xuezhong Cai;Alexandra Schäfer;Shihua Lu;John P Bilello

Frequent Co-Authors

Hal P. Bogerd
Hal P. Bogerd Duke University
Michael H. Malim
Michael H. Malim King's College London
Warner C. Greene
Warner C. Greene University of California, San Francisco
Yibin Kang
Yibin Kang Princeton University
Paul D. Bieniasz
Paul D. Bieniasz Rockefeller University
Jacob V. Maizel
Jacob V. Maizel National Institutes of Health
Henri Jacques Delecluse
Henri Jacques Delecluse Grenoble Alpes University
Hashim M. Al-Hashimi
Hashim M. Al-Hashimi Duke University
Uwe Ohler
Uwe Ohler Max Delbrück Center for Molecular Medicine
Ronald Swanstrom
Ronald Swanstrom University of North Carolina at Chapel Hill

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