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Molecular Biology
Switzerland
2026
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Genetics and Molecular Biology
Switzerland
2024

D-Index & Metrics

Molecular Biology

D-Index
122
Citations
67468
World Ranking
238
National Ranking
3

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in Switzerland Leader Award
  • 2025 - Research.com Molecular Biology in Switzerland Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Switzerland Leader Award
  • 2023 - Research.com Molecular Biology in Switzerland Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Switzerland Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Didier Trono is affiliated with the École Polytechnique Fédérale de Lausanne in Switzerland. Their research spans over various fields of biochemistry, genetics, molecular biology, and medicine, with significant contributions to molecular biology and infectious diseases, among other subfields.

The main areas of study in their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

The subfields of focus are:

  • Molecular Biology
  • Infectious Diseases
  • Plant Science
  • Oncology
  • Modeling and Simulation

Within these areas, Didier Trono has concentrated on several key topics:

  • SARS-CoV-2 and COVID-19 Research
  • Chromosomal and Genetic Variations
  • Genomics and Chromatin Dynamics
  • COVID-19 Clinical Research Studies
  • RNA and protein synthesis mechanisms
  • RNA modifications and cancer
  • SARS-CoV-2 detection and testing

Several frequent publication venues highlight the outlets in which their work appears most often:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Science Advances
  • Cancer Research

Frequent collaborators include:

  • Evarist Planet
  • Julien Duc
  • Charlène Raclot
  • Priscilla Turelli
  • Laurent Kaiser

Among the recent papers authored or coauthored by Didier Trono are:

  • Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study, 2020, The Lancet
  • Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes, 2020, Nature Communications
  • Changes in SARS-CoV-2 Spike versus Nucleoprotein Antibody Responses Impact the Estimates of Infections in Population-Based Seroprevalence Studies, 2020, Journal of Virology
  • De novo design of protein interactions with learned surface fingerprints, 2023, Nature
  • Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland, 2020, The Lancet Infectious Diseases

Didier Trono holds the distinction of being a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

    Luigi Naldini;Ulrike Blömer;Philippe Gallay;Daniel Ory

  • A Third-Generation Lentivirus Vector with a Conditional Packaging System

    Tom Dull;Romain Zufferey;Michael Kelly;R. J. Mandel

  • Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.

    Romain Zufferey;Dea Nagy;Ron J. Mandel;Luigi Naldini

  • Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery

    Romain Zufferey;Thomas Dull;Ronald J. Mandel;Anatoly Bukovsky

  • Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

    Luigi Naldini;Ulrike Blomer;Fred H. Gage;Didier Trono

  • Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

    Bastien Mangeat;Priscilla Turelli;Gersende Caron;Marc Friedli

  • Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors

    Romain Zufferey;John E. Donello;Didier Trono;Thomas J. Hope

  • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.

    Jeffrey H. Kordower;Marina E. Emborg;Jocelyne Bloch;Shuang Y. Ma

  • Embryonic stem cell potency fluctuates with endogenous retrovirus activity

    Todd S. Macfarlan;Wesley D. Gifford;Shawn Driscoll;Karen Lettieri

  • Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Geneva, Switzerland (SEROCoV-POP): a population-based study.

    Silvia Stringhini;Silvia Stringhini;Silvia Stringhini;Ania Wisniak;Giovanni Piumatti;Giovanni Piumatti;Andrew S Azman;Andrew S Azman

  • Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

    Christopher Aiken;Jason Konner;Nathaniel R. Landau;Marc E. Lenburg;Marc E. Lenburg

  • Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector.

    Ulrike Blömer;Luigi Naldini;Tal Kafri;Didier Trono

  • Conditional Suppression of Cellular Genes: Lentivirus Vector-Mediated Drug-Inducible RNA Interference

    Maciej Wiznerowicz;Didier Trono

  • KAP1 controls endogenous retroviruses in embryonic stem cells

    Helen M. Rowe;Johan Jakobsson;Johan Jakobsson;Daniel Mesnard;Jacques Rougemont

  • Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa

    Volker Busskamp;Jens Duebel;David Balya;Mathias Fradot;Mathias Fradot;Mathias Fradot

  • HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.

    Philippe Gallay;Thomas Hope;Daniel Chin;Didier Trono

  • Vector and method of use for nucleic acid delivery to non-dividing cells

    Inder Verma;Didier Trono;Luigi Naldini;Philippe Gallay

  • In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.

    Simon Quenneville;Gaetano Verde;Andrea Corsinotti;Adamandia Kapopoulou

  • Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells.

    U. Von Schwedler;Jinping Song;C. Aiken;D. Trono

  • HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase

    Philippe Gallay;Simon Swingler;Jinping Song;Frederic Bushman

Frequent Co-Authors

Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences
Philippe Gallay
Philippe Gallay Scripps Research Institute
Luigi Naldini
Luigi Naldini Vita-Salute San Raffaele University
François-Loïc Cosset
François-Loïc Cosset Claude Bernard University Lyon 1
Stefan Karlsson
Stefan Karlsson Lund University
Christopher Aiken
Christopher Aiken Vanderbilt University Medical Center
Bart Deplancke
Bart Deplancke École Polytechnique Fédérale de Lausanne
Olivier Michielin
Olivier Michielin University of Lausanne
Thomas J. Hope
Thomas J. Hope Northwestern University
Inder M. Verma
Inder M. Verma Salk Institute for Biological Studies

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