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Microbiology

D-Index
80
Citations
25298
World Ranking
1152
National Ranking
522

Overview

Thomas J. Hope is affiliated with Northwestern University in the United States. Their research spans primarily the fields of Medicine and Immunology and Microbiology, with a significant focus on Infectious Diseases, Virology, Epidemiology, Immunology, and Molecular Biology. The scientist's work predominantly addresses topics related to HIV research and treatment, cytomegalovirus and herpesvirus research, and SARS-CoV-2 and COVID-19 research.

Hope's recent notable papers include:

  • Functional landscape of SARS-CoV-2 cellular restriction, 2021, Molecular Cell
  • Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2, 2022, Nature Communications
  • Recommendations for measuring HIV reservoir size in cure-directed clinical trials, 2020, Nature Medicine
  • Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA, 2022, Molecular Cell
  • Design and Testing of a Cabotegravir Implant for HIV Prevention, 2020, Journal of Controlled Release

Frequent frequent coauthors of Thomas J. Hope include Michael D. McRaven, François Villinger, Yanique Thomas, Mariluz Araínga, and Ramon Lorenzo-Redondo, reflecting active collaboration within their areas of study.

The scientist's work has been published extensively in several key venues, most frequently in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • AIDS Research and Human Retroviruses
  • Nature Communications
  • Frontiers in Immunology
  • Journal of Virology

Key research topics covered in their publications include:

  • HIV Research and Treatment
  • Cytomegalovirus and herpesvirus research
  • HIV/AIDS Research and Interventions
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • HIV/AIDS drug development and treatment
  • Immune Cell Function and Interaction

Thomas J. Hope's contributions encompass both foundational studies in viral immunology and applied research focused on developing interventions for viral infections, particularly within the context of HIV and SARS-CoV-2. Their work includes examining viral-host interactions, immune sensing mechanisms, and therapeutic delivery systems.

Best Publications

  • Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors

    Romain Zufferey;John E. Donello;Didier Trono;Thomas J. Hope

  • Visualization of the intracellular behavior of HIV in living cells

    David McDonald;Marie A. Vodicka;Ginger Lucero;Tatyana M. Svitkina

  • A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.

    Jayne M. Stommel;Natalie D. Marchenko;Gretchen S. Jimenez;Ute M. Moll

  • Recruitment of HIV and its receptors to dendritic cell-T cell junctions.

    David McDonald;Li Wu;Stacy M. Bohks;Vineet N. KewalRamani

  • HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway.

    Philippe Gallay;Thomas Hope;Daniel Chin;Didier Trono

  • Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation.

    Aisha Nazli;Olivia Chan;Wendy N. Dobson-Belaire;Michel Ouellet

  • Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

    Melissa E. Elder;Dong Lin;Jared Clever;Andrew C. Chan

  • ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

    Mirit I. Aladjem;Benjamin T. Spike;Luo Wei Rodewald;Thomas J. Hope

  • HIV-1 capsid: the multifaceted key player in HIV-1 infection

    Edward M. Campbell;Thomas J. Hope

  • Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

    Hugo Mouquet;Johannes F. Scheid;Johannes F. Scheid;Markus J. Zoller;Michelle Krogsgaard

  • Woodchuck Hepatitis Virus Contains a Tripartite Posttranscriptional Regulatory Element

    John E. Donello;Jonathan E. Loeb;Thomas J. Hope

  • A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

    Shuo Xiao;Jonathan R. Coppeta;Hunter B. Rogers;Brett C. Isenberg

  • Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II

    Wilma A. Hofmann;Ljuba Stojiljkovic;Beata Fuchsova;Gabriela M. Vargas

  • PRC1: A Human Mitotic Spindle–Associated CDK Substrate Protein Required for Cytokinesis

    Wei Jiang;Gretchen Jimenez;Nicholas J Wells;Thomas J Hope

  • Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase

    Salme Taagepera;David McDonald;Jonathan E. Loeb;Laura L. Whitaker

  • An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα

    Connie Johnson;Daniel Van Antwerp;Daniel Van Antwerp;Thomas J. Hope

  • Proteasome inhibitors uncouple rhesus TRIM5α restriction of HIV-1 reverse transcription and infection

    Xiaolu Wu;Jenny L. Anderson;Edward M. Campbell;Ajith M. Joseph

  • Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription.

    Amy E. Hulme;Omar Perez;Thomas J. Hope

  • Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif

    Maria L. Zapp;Thomas J. Hope;Tristram G. Parslow;Michael R. Green

  • Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy.

    Jonathan E. Loeb;Wendy S. Cordier;Matthew E. Harris;Matthew D. Weitzman

Frequent Co-Authors

Ronald S. Veazey
Ronald S. Veazey Tulane University
Tristram G. Parslow
Tristram G. Parslow Emory University
Didier Trono
Didier Trono École Polytechnique Fédérale de Lausanne
Anna-Lise Williamson
Anna-Lise Williamson University of Cape Town
Grant J. Jensen
Grant J. Jensen California Institute of Technology
Glenda Gray
Glenda Gray South African Medical Research Council
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Richard T. D'Aquila
Richard T. D'Aquila Northwestern University
Francesca Chiodi
Francesca Chiodi Karolinska Institute
Linda-Gail Bekker
Linda-Gail Bekker University of Cape Town

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