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Biology and Biochemistry

D-Index
62
Citations
14905
World Ranking
10719
National Ranking
4654

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Christopher Aiken is affiliated with Vanderbilt University Medical Center in the United States. Their research primarily focuses on the biology and treatment of HIV, contributing to fields such as immunology, microbiology, biochemistry, genetics, molecular biology, and medicine.

The main topics of their work include:

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • RNA Research and Splicing
  • Bacteriophages and microbial interactions
  • RNA Interference and Gene Delivery
  • Nuclear Structure and Function
  • Immune Cell Function and Interaction

Their subfields of study cover:

  • Virology
  • Molecular Biology
  • Infectious Diseases
  • Ecology
  • Immunology

Aiken's recent published papers include:

  • Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A, 2020, Nature Structural & Molecular Biology
  • Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis, 2020, PLoS Biology
  • Modeling HIV-1 nuclear entry with nucleoporin-gated DNA-origami channels, 2023, Nature Structural & Molecular Biology
  • CryoET structures of immature HIV Gag reveal six-helix bundle, 2021, Communications Biology
  • The HIV-1 capsid and reverse transcription, 2021, Retrovirology

Frequent co-authors collaborating with Aiken include:

  • Jiong Shi
  • Juan R. Perilla
  • Alan Engelman
  • Itay Rousso

Aiken often publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • PLoS Pathogens
  • Journal of Virology
  • Biophysical Journal
  • Nature Structural & Molecular Biology

Among distinctions, Aiken was named a Fellow of the American Association for the Advancement of Science (AAAS) in 2013.

Best Publications

  • Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain.

    Christopher Aiken;Jason Konner;Nathaniel R. Landau;Marc E. Lenburg;Marc E. Lenburg

  • Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

    Gongpu Zhao;Juan R. Perilla;Ernest L. Yufenyuy;Ernest L. Yufenyuy;Xin Meng

  • Formation of a Human Immunodeficiency Virus Type 1 Core of Optimal Stability Is Crucial for Viral Replication

    Brett M. Forshey;Uta von Schwedler;Wesley I. Sundquist;Christopher Aiken

  • Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells.

    U. Von Schwedler;Jinping Song;C. Aiken;D. Trono

  • Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.

    Christopher Aiken

  • Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis.

    C Aiken;D Trono

  • HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

    Philippe Gallay;Simon Swingler;Christopher Aiken;Didier Trono

  • Assembly Properties of the Human Immunodeficiency Virus Type 1 CA Protein

    Barbie K. Ganser-Pornillos;Uta K. von Schwedler;Kirsten M. Stray;Christopher Aiken

  • Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

    Arne Schneidewind;Mark A. Brockman;Mark A. Brockman;Ruifeng Yang;Rahma I. Adam

  • Structural convergence between Cryo-EM and NMR reveals intersubunit interactions critical for HIV-1 capsid function.

    In-Ja L. Byeon;Xin Meng;Jinwon Jung;Gongpu Zhao

  • Host Cofactors and Pharmacologic Ligands Share an Essential Interface in HIV-1 Capsid That Is Lost upon Disassembly.

    Amanda J. Price;David A. Jacques;William A. McEwan;Adam J. Fletcher

  • Coupling of Human Immunodeficiency Virus Type 1 Fusion to Virion Maturation: a Novel Role of the gp41 Cytoplasmic Tail

    Donald J. Wyma;Jiyang Jiang;Jiong Shi;Jing Zhou

  • Evidence for a Functional Link between Uncoating of the Human Immunodeficiency Virus Type 1 Core and Nuclear Import of the Viral Preintegration Complex

    David J. Dismuke;Christopher Aiken

  • Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Infection by Virus Capsid Destabilization

    Jiong Shi;Jing Zhou;Vaibhav B. Shah;Christopher Aiken

  • Evidence for a stable interaction of gp41 with Pr55(Gag) in immature human immunodeficiency virus type 1 particles.

    Donald J. Wyma;Alexander Kotov;Christopher Aiken

  • Betulinic acid derivatives as HIV-1 antivirals

    Christopher Aiken;Chin Ho Chen

  • HIV-1 uncoating: connection to nuclear entry and regulation by host proteins.

    Zandrea Ambrose;Christopher Aiken

  • Small-Molecule Inhibition of Human Immunodeficiency Virus Type 1 Replication by Specific Targeting of the Final Step of Virion Maturation

    Jing Zhou;Xiong Yuan;David Dismuke;Brett M. Forshey

  • The HIV-1 Nef Protein Acts as a Connector with Sorting Pathways in the Golgi and at the Plasma Membrane

    Aram Mangasarian;Michelangelo Foti;Christopher Aiken;Daniel Chin

  • Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes

    Christopher A. Lundquist;Minoru Tobiume;Jing Zhou;Derya Unutmaz

Frequent Co-Authors

Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh
Didier Trono
Didier Trono École Polytechnique Fédérale de Lausanne
Tatyana Polenova
Tatyana Polenova University of Delaware
Alan Engelman
Alan Engelman Harvard University
Klaus Schulten
Klaus Schulten University of Illinois at Urbana-Champaign
Chin Ho Chen
Chin Ho Chen Duke University
Philippe Gallay
Philippe Gallay Scripps Research Institute
William Furey
William Furey University of Pittsburgh
Wesley I. Sundquist
Wesley I. Sundquist University of Utah
Eric O. Freed
Eric O. Freed National Institutes of Health

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