World's Best Scientists 2026 revealed!

Overview

Chin Ho Chen is affiliated with Duke University in the United States and has contributed to research primarily in the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their work spans several subfields including Molecular Biology, Infectious Diseases, Virology, Pharmacology, and Biotechnology.

The focus of Chen's research centers around topics such as:

  • Bioactive Natural Diterpenoids Research
  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Natural product bioactivities and synthesis
  • Marine Sponges and Natural Products
  • Biological Activity of Diterpenoids and Biflavonoids
  • Phytochemistry and Biological Activities

Chen has published numerous papers, with research articles appearing frequently in several scientific journals. Notable recent publications include:

  • Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities (2020, European Journal of Medicinal Chemistry)
  • Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities (2020, Journal of Medicinal Chemistry)
  • Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors (2021, European Journal of Medicinal Chemistry)
  • Bioactive ent-isopimarane diterpenoids from Euphorbia neriifolia (2020, Phytochemistry)
  • Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora (2020, Journal of Natural Products)

The frequent venues for Chen's publications include:

  • Journal of Natural Products
  • UNC Libraries
  • European Journal of Medicinal Chemistry
  • Journal of Natural Medicines
  • OPAL (Open@LaTrobe) (La Trobe University)

Chen collaborates often with multiple coauthors. Frequent collaborators are:

  • Kuo-Hsiung Lee
  • Li Huang
  • Kouharu Otsuki
  • Wei Li
  • Susan L. Morris-Natschke

Best Publications

  • Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents

    Y. Kashiwada;F. Hashimoto;L. M. Cosentino;Chin-Ho Chen

  • Delayed cytotoxicity and selective loss of mitochondrial DNA in cells treated with the anti-human immunodeficiency virus compound 2',3'-dideoxycytidine.

    C H Chen;Y C Cheng

  • Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity.

    Chin-Ho Chen;M. Vazquez-Padua;Yung-Chi Cheng

  • A molecular clasp in the human immunodeficiency virus (HIV) type 1 TM protein determines the anti-HIV activity of gp41 derivatives: implication for viral fusion.

    Chin-Ho Chen;T. J. Matthews;C. B. Mcdanal;D. P. Bolognesi

  • Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.

    Sun Ic;Wang Hk;Kashiwada Y;Shen Jk

  • Betulinic acid derivatives as HIV-1 antivirals

    Christopher Aiken;Chin Ho Chen

  • Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.

    Fumio Hashimoto;Fumio Hashimoto;Yoshiki Kashiwada;L. Mark Cosentino;Chin Ho Chen

  • Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

    Donglei Yu;Yojiro Sakurai;Chin Ho Chen;Fang Rong Chang

  • Anti-AIDS Agents. 15. Synthesis and Anti-HIV Activity of Dihydroseselins and Related Analogs

    Li Huang;Y. Kashiwada;L. M. Cosentino;Sharon Fan

  • The role of cytoplasmic deoxycytidine kinase in the mitochondrial effects of the anti-human immunodeficiency virus compound, 2',3'-dideoxycytidine.

    Chin-Ho Chen;Yung-Chi Cheng

  • Activation and inhibition of the proteasome by betulinic acid and its derivatives

    Li Huang;Phong Ho;Chin-Ho Chen

  • Proteasome regulators: activators and inhibitors

    Li Huang;Chin Ho Chen

  • Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives

    Li Huang;Phong Ho;Kuo Hsiung Lee;Chin Ho Chen

  • Role of Human Immunodeficiency Virus (HIV) Type 1 Envelope in the Anti-HIV Activity of the Betulinic Acid Derivative IC9564

    Sonia L. Holz-Smith;I-Chen Sun;Lei Jin;Thomas J. Matthews

  • Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.

    Jing Zhou;Li Huang;David L. Hachey;Chin Ho Chen

  • Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents.

    Donglei Yu;§ Chin-Ho Chen;and Arnold Brossi;‡ Kuo-Hsiung Lee

  • Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid

    I-Chen Sun;Chin-Ho Chen;Yoshiki Kashiwada;Jiu-Hong Wu

  • Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L.

    Yoshihisa Asada;Aya Sukemori;Takashi Watanabe;Kuber J. Malla

  • Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

    Ye Tian;Zhaoqiang Liu;Jinghan Liu;Boshi Huang

  • Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

    Keduo Qian;Donglei Yu;Chin Ho Chen;Li Huang

Frequent Co-Authors

Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Susan L. Morris-Natschke
Susan L. Morris-Natschke University of North Carolina at Chapel Hill
Peng Zhan
Peng Zhan Shandong University
Xinyong Liu
Xinyong Liu Shandong University
Yoshiki Kashiwada
Yoshiki Kashiwada University of Tokushima
Dani P. Bolognesi
Dani P. Bolognesi Duke University
Kent J. Weinhold
Kent J. Weinhold Duke University
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Christopher Aiken
Christopher Aiken Vanderbilt University Medical Center
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research

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