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Microbiology

D-Index
57
Citations
11429
World Ranking
3579
National Ranking
314

Overview

Mark Krystal is affiliated with ViiV Healthcare in the United Kingdom and has a research focus primarily rooted in Medicine and Immunology and Microbiology. Their work spans several subfields including Infectious Diseases, Virology, Molecular Biology, Epidemiology, and Materials Chemistry.

The scientist's research centers significantly on HIV, addressing both the biological underpinnings and treatment strategies. Main topics explored include:

  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Biochemical and Molecular Research
  • HIV/AIDS Research and Interventions
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography

Mark Krystal has contributed publications within several prominent venues, with the most frequent being:

  • Journal of Medicinal Chemistry (6 publications)
  • The Cambridge Structural Database (4 publications)
  • Antimicrobial Agents and Chemotherapy (3 publications)
  • Bioorganic & Medicinal Chemistry Letters (3 publications)
  • Immunity (2 publications)

Frequent collaborators include Nicholas A. Meanwell (21 joint works), Susan Jenkins (17), Umesh Hanumegowda (15), Dawn D. Parker (14), and John F. Kadow (10).

Selected recent papers authored or co-authored by Mark Krystal include:

  • Human immunoglobulin repertoire analysis guides design of vaccine priming immunogens targeting HIV V2-apex broadly neutralizing antibody precursors, 2022, Immunity
  • Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice, 2022, Immunity
  • Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors, 2020, Journal of Medicinal Chemistry
  • The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation, 2022, Journal of Medicinal Chemistry
  • Susceptibility of global HIV-1 clinical isolates to fostemsavir using the PhenoSense® Entry assay, 2020, Journal of Antimicrobial Chemotherapy

Best Publications

  • Amplification, expression, and packaging of a foreign gene by influenza virus

    Willem Luytjes;Mark Krystal;Masayoshi Enami;Jeffrey D. Parvin

  • Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes

    Norman Arnheim;Mark Krystal;Roy Schmickel;Golder Wilson

  • Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle

    Ming-Ta Hsu;Jeffrey D. Parvin;Suresh Gupta;Mark Krystal

  • Introduction of site-specific mutations into the genome of influenza virus.

    Masayoshi Enami;Willem Luytjes;Mark Krystal;Peter Palese

  • Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in NS gene

    Deborah A. Buonagurio;Susumu Nakada;Jeffrey D. Parvin;Mark Krystal

  • A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human δ and β globin genes

    Roger Miesfeld;Mark Krystal;Norman Amheim

  • Determination of influenza virus proteins required for genome replication.

    Tao-Sheng Huang;P. Palese;M. Krystal

  • Influenza B virus evolution: Co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C viruses

    Makoto Yamashita;Mark Krystal;Walter M. Fitch;Peter Palese

  • Two nuclear location signals in the influenza virus NS1 nonstructural protein.

    D Greenspan;P Palese;M Krystal

  • Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes

    Mark Krystal;Richard M. Elliott;Edmund W. Benz;James F. Young

  • Promoter analysis of influenza virus RNA polymerase.

    J D Parvin;P Palese;A Honda;A Ishihama

  • Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity.

    M. Hagen;T. D. Y. Chung;J. A. Butcher;M. Krystal

  • Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5' ends of the viral RNAs.

    L S Tiley;M Hagen;J T Matthews;M Krystal

  • Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

    Samuel W. Gerritz;Christopher Cianci;Sean Kim;Bradley C. Pearce

  • Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

    Christopher Cianci;Kuo-Long Yu;Keith Combrink;Ny Sin

  • Rescue of a foreign gene by Sendai virus.

    Kyeong H. Park;Taosheng Huang;Frederick F. Correia;Mark Krystal

  • In Vitro Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068

    Beata Nowicka-Sans;Yi-Fei Gong;Brian McAuliffe;Ira Dicker

  • Differential Activation of the Influenza Virus Polymerase via Template RNA Binding

    C Cianci;L Tiley;M Krystal

  • Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains

    Mark Krystal;James F. Young;Peter Palese;Ian A. Wilson

  • Noncumulative sequence changes in the hemagglutinin genes of influenza C virus isolates.

    Deborah A. Buonagurio;Susumu Nakada;Ulrich Desselberger;Mark Krystal

Frequent Co-Authors

Nicholas A. Meanwell
Nicholas A. Meanwell Bristol-Myers Squibb (Germany)
Peter Palese
Peter Palese Icahn School of Medicine at Mount Sinai
Richard J. Colonno
Richard J. Colonno Bristol-Myers Squibb (Germany)
Guangxiang Luo
Guangxiang Luo University of Alabama at Birmingham
Jeffrey D. Parvin
Jeffrey D. Parvin The Ohio State University
Norman Arnheim
Norman Arnheim University of Southern California
Douglas S. Lyles
Douglas S. Lyles Wake Forest University
Robert A. Lamb
Robert A. Lamb Northwestern University
Walter M. Fitch
Walter M. Fitch University of California, Irvine
Oliver A. Ryder
Oliver A. Ryder University of California, San Diego

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