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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
100
Citations
32796
World Ranking
1539
National Ranking
95

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2015 - Fellow of the Royal Society, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Stephen Cusack is affiliated with the European Bioinformatics Institute in the United Kingdom. Their research spans multiple fields within Biochemistry, Genetics and Molecular Biology, as well as Medicine. The main subfields of study include Molecular Biology, Infectious Diseases, Immunology, Epidemiology, and Public Health, Environmental and Occupational Health.

Their work covers a range of topics primarily related to RNA and protein synthesis mechanisms, interferon and immune responses, and influenza virus research studies. Further topics of interest include viral infections and vectors, RNA research and splicing, RNA modifications and cancer, and mosquito-borne diseases and control.

Recent publications demonstrate a focus on viral polymerases and genome replication processes. Selected papers include:

  • "A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase," 2020, Cell
  • "The Cap-Snatching Mechanism of Bunyaviruses," 2020, Trends in Microbiology
  • "Structure and Function of Influenza Polymerase," 2020, Cold Spring Harbor Perspectives in Medicine
  • "Structural and functional characterization of the severe fever with thrombocytopenia syndrome virus L protein," 2020, Nucleic Acids Research
  • "The mechanism of genome replication and transcription in bunyaviruses," 2023, PLoS Pathogens

Frequent co-authors contributing to their research include Benoît Arragain, Tim Krischuns, Nadia Naffakh, Maria Rosenthal, and Petra Drncová. The collaboration with these researchers is reflected through multiple joint publications.

Stephen Cusack has published extensively in several prominent scientific venues, often contributing to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nucleic Acids Research
  • PLoS Pathogens
  • Cell Reports

They have received recognition in the form of prestigious awards including being named a Fellow of the Royal Society in the United Kingdom in 2015 and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

    W. Weis;J. H. Brown;S. Cusack;S. Cusack;J. C. Paulson

  • Dynamical transition of myoglobin revealed by inelastic neutron scattering.

    Wolfgang Doster;Stephen Cusack;Winfried Petry

  • The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit

    Alexandre Dias;Denis Bouvier;Thibaut Crépin;Andrew A. McCarthy

  • Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

    Eva Kowalinski;Thomas Lunardi;Andrew A. McCarthy;Jade Louber

  • A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 A.

    Stephen Cusack;Carmen Berthet-Colominas;Michael Härtlein;Nicolas Nassar

  • An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site.

    Fernando L. Rock;Weimin Mao;Anya Yaremchuk;Mikhail Tukalo

  • The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2.

    Delphine Guilligay;Franck Tarendeau;Patricia Resa-Infante;Rocío Coloma

  • The 2.9 A crystal structure of T. thermophilus seryl-tRNA synthetase complexed with tRNA(Ser).

    Valerie Biou;Anna Yaremchuk;Michael Tukalo;Stephen Cusack

  • Structure of influenza A polymerase bound to the viral RNA promoter

    Alexander Pflug;Delphine Guilligay;Stefan Reich;Stephen Cusack

  • Structural insight into cap-snatching and RNA synthesis by influenza polymerase

    Stefan Reich;Delphine Guilligay;Alexander Pflug;Hélène Malet

  • A triple beta-spiral in the adenovirus fibre shaft reveals a new structural motif for a fibrous protein.

    M.J Van Raaij;A Mitraki;G Lavigne;S. Cusack

  • Structure and Nuclear Import Function of the C- Terminal Domain of Influenza Virus Polymerase Pb2 Subunit

    Franck Tarendeau;Julien Boudet;Delphine Guilligay;Philippe J Mas

  • The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid.

    W. P. Burmeister;R. W. H. Ruigrok;S. Cusack

  • The structure of the Escherichia coli EF-Tu. EF-Ts complex at 2.5 Å resolution

    Takemasa Kawashima;Carmen Berthet-Colominas;Michael Wulff;Stephen Cusack

  • Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

    Shinya Omoto;Valentina Speranzini;Takashi Hashimoto;Takeshi Noshi

  • Structure of influenza virus RNP. I. Influenza virus nucleoprotein melts secondary structure in panhandle RNA and exposes the bases to the solvent.

    F. Baudin;C. Bach;S. Cusack;R. W. H. Ruigrok

  • Aminoacyl-tRNA synthetases.

    Stephen Cusack

  • The 2 Å crystal structure of leucyl‐tRNA synthetase and its complex with a leucyl‐adenylate analogue

    Stephen Cusack;Anna Yaremchuk;Michael Tukalo

  • Sequence, structural and evolutionary relationships between class 2 aminoacyl-tRNA synthetases

    Stephen Cusack;Michael Härtlein;Reuben Leberman

  • Determination of the elastic constants of collagen by Brillouin light scattering.

    S. Cusack;A. Miller

Frequent Co-Authors

Rob W.H. Ruigrok
Rob W.H. Ruigrok Grenoble Alpes University
Mark D. Smith
Mark D. Smith University of South Carolina
Guy Schoehn
Guy Schoehn Grenoble Alpes University
Nadia Naffakh
Nadia Naffakh Institut Pasteur
Thierry Langer
Thierry Langer University of Vienna
Raimond B. G. Ravelli
Raimond B. G. Ravelli Maastricht University
Jeremy C. Smith
Jeremy C. Smith University of Tennessee at Knoxville
Iain W. Mattaj
Iain W. Mattaj Human Technopole
Martin Karplus
Martin Karplus Harvard University
Hugues Lortat-Jacob
Hugues Lortat-Jacob Grenoble Alpes University

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