World's Best Scientists 2026 revealed!
Hugues Lortat-Jacob

Hugues Lortat-Jacob

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
12335
World Ranking
8866
National Ranking
313

Overview

Hugues Lortat-Jacob is affiliated with Grenoble Alpes University in France. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with 28 publications in this overall area. Within this domain, Lortat-Jacob's work covers Molecular Biology, Cell Biology, Organic Chemistry, Immunology, and Cancer Research.

The primary research topics addressed in their publications include:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Protease and Inhibitor Mechanisms
  • Neurobiology and Insect Physiology Research
  • Invertebrate Immune Response Mechanisms
  • Platelet Disorders and Treatments

Notable recent papers authored include:

  • Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity, 2020, Molecules
  • Structure of the human heparan sulfate polymerase complex EXT1-EXT2, 2022, Nature Communications
  • IFNγ binding to extracellular matrix prevents fatal systemic toxicity, 2023, Nature Immunology
  • Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity, 2022, Cell Reports
  • Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling, 2021, Nature Communications

Frequent co-authors in Lortat-Jacob's publications include Evelyne Gout, Rebekka Wild, Romain R. Vivès, Rabia Sadir, and Yoann Crétinon. This collaborative network reflects ongoing partnerships across various projects.

Lortat-Jacob's work has appeared predominantly in the following publication venues:

  • Nature Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • EMPIAR dataset
  • Molecules

Best Publications

  • DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2

    Pierre-Yves Lozach;Hugues Lortat-Jacob;Agnès de Lacroix de Lavalette;Isabelle Staropoli

  • Human Cytomegalovirus Binding to DC-SIGN Is Required for Dendritic Cell Infection and Target Cell trans-Infection

    Franck Halary;Ali Amara;Hugues Lortat-Jacob;Martin Messerle

  • Endocan or endothelial cell specific molecule-1 (ESM-1) : A potential novel endothelial cell marker and a new target for cancer therapy

    Stéphane Sarrazin;E. Adam;M. Lyon;F. Depontieu

  • Selective Interactions of Polyanions with Basic Surfaces on Human Immunodeficiency Virus Type 1 gp120

    Maxime Moulard;Hugues Lortat-Jacob;Isabelle Mondor;Guillaume Roca

  • Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine.

    Ali Amara;Olivier Lorthioir;Agustin Valenzuela;Aude Magerus

  • Structural diversity of heparan sulfate binding domains in chemokines.

    Hugues Lortat-Jacob;Aurélien Grosdidier;Anne Imberty

  • Sulfated polysaccharides increase plasma levels of SDF-1 in monkeys and mice: involvement in mobilization of stem/progenitor cells

    Elizabeth A. Sweeney;Hugues Lortat-Jacob;Gregory V. Priestley;Betty Nakamoto

  • Heparan sulfate-mediated binding of infectious dengue virus type 2 and yellow fever virus.

    Raphaële Germi;Jean-Marc Crance;Daniel Garin;Josette Guimet

  • Characterization of the stromal cell-derived factor-1alpha-heparin complex.

    Rabia Sadir;Françoise Baleux;Aurélien Grosdidier;Aurélien Grosdidier;Anne Imberty

  • Structural view of glycosaminoglycan-protein interactions.

    Anne Imberty;Hugues Lortat-Jacob;Serge Pérez

  • Heparan Sulfate/Heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 against Proteolysis Induced by CD26/Dipeptidyl Peptidase IV *

    Rabia Sadir;Anne Imberty;Françoise Baleux;Hugues Lortat-Jacob

  • Cellular glycosaminoglycans and low density lipoprotein receptor are involved in hepatitis C virus adsorption.

    Raphaële Germi;Jean-Marc Crance;Daniel Garin;Josette Guimet

  • The Fucose-Binding Lectin from Ralstonia Solanacearum: A New Type of {Beta}-Propeller Architecture Formed by Oligomerization and Interacting with Fucoside, Fucosyllactose, and Plant Xyloglucan.

    Nikola Kostlánová;Edward P. Mitchell;Hugues Lortat-Jacob;Stefan Oscarson

  • Molecular organization of the interferon gamma-binding domain in heparan sulphate.

    H Lortat-Jacob;Jeremy E Turnbull;J A Grimaud

  • Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence.

    Hugues Lortat-Jacob;Frederic Baltzer;Jean-Alexis Grimaud

  • Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site.

    Romain R. Vivès;Anne Imberty;Quentin J. Sattentau;Hugues Lortat-Jacob

  • A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

    Françoise Baleux;Latino Loureiro-Morais;Yael Hersant;Pascal Clayette

  • Inflammatory chemokines direct and restrict leukocyte migration within live tissues as glycan-bound gradients.

    Milka Sarris;Milka Sarris;Jean-Baptiste Masson;Jean-Baptiste Masson;Damien Maurin;Lieke M. Van der Aa;Lieke M. Van der Aa

  • Characterization of Endostatin Binding to Heparin and Heparan Sulfate by Surface Plasmon Resonance and Molecular Modeling ROLE OF DIVALENT CATIONS

    Sylvie Ricard-Blum;Olivier Féraud;Hugues Lortat-Jacob;Anna Rencurosi

  • High-affinity binding of interferon-gamma to a basement membrane complex (matrigel).

    Hugues Lortat-Jacob;H. K. Kleinman;J. A. Grimaud

Frequent Co-Authors

Fernando Arenzana-Seisdedos
Fernando Arenzana-Seisdedos Chinese Academy of Sciences
Anne Imberty
Anne Imberty Grenoble Alpes University
Philippe Lassalle
Philippe Lassalle Institut Pasteur
Catherine Picart
Catherine Picart Grenoble Alpes University
Patricia Rousselle
Patricia Rousselle Institut de Biologie et de Chimie des Protéines
Stephen Cusack
Stephen Cusack European Bioinformatics Institute
Franck Fieschi
Franck Fieschi Grenoble Alpes University
Yves Bourne
Yves Bourne Aix-Marseille University
Malcolm Lyon
Malcolm Lyon University of Manchester
Rob W.H. Ruigrok
Rob W.H. Ruigrok Grenoble Alpes University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Biology and Biochemistry can lead to diverse career paths in health sciences, research, and healthcare technology. Many students choose to enhance their expertise by pursuing further education in specialized fields, particularly through flexible online programs designed to fit busy schedules.

For those interested in human health and wellness, earning a nutrition masters online provides advanced knowledge for careers in clinical nutrition, wellness coaching, or research. Additionally, the best schools for masters in nutrition offer rigorous, accredited curricula to help students meet professional and personal goals.

If you prefer technology-driven health roles, consider ultrasound tech programs online for a pathway into medical imaging, or explore accelerated radiology tech programs online for fast-track entry to diagnostic radiology careers. These degrees offer practical skills and outstanding job prospects with strong demand across healthcare settings.

Online education makes advanced qualifications more accessible, allowing you to build your career in biology, biochemistry, nutrition, or medical technology on your own terms.

Best Scientists Citing Hugues Lortat-Jacob

Trending Scientists

Recently Published Articles