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D-Index & Metrics

Chemistry

D-Index
78
Citations
21422
World Ranking
3807
National Ranking
1221

Biology and Biochemistry

D-Index
79
Citations
21588
World Ranking
4329
National Ranking
2109

Overview

Tracy M. Handel is affiliated with the University of Montana in the United States. Their research spans multiple fields within biomedical science, focusing primarily on molecular mechanisms related to chemokine receptors and immune signaling.

The scientist's main fields of study include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Their subfields of study cover:

  • Oncology
  • Molecular Biology
  • Immunology
  • Radiology, Nuclear Medicine and Imaging
  • Cell Biology

The primary research topics addressed by Handel involve:

  • Chemokine receptors and signaling
  • Receptor Mechanisms and Signaling
  • Monoclonal and Polyclonal Antibodies Research
  • T-cell and B-cell Immunology
  • Glycosylation and Glycoproteins Research
  • Immunotherapy and Immune Responses
  • Cytokine Signaling Pathways and Interactions

Notable recent publications by Handel include:

  • Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias (2022, Science Advances)
  • Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors (2023, Cell Reports)
  • Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis (2020, Science Signaling)
  • Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity (2020, PLoS Biology)
  • Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t (2020, Journal of Biological Chemistry)

Frequent co-authors collaborating with Handel are:

  • Irina Kufareva
  • Christopher T. Schafer
  • Martin Gustavsson
  • Catherina L. Salanga
  • J.J.G. Tesmer

Common venues where Handel's work has been published include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The FASEB Journal
  • Biophysical Journal
  • Science Signaling
  • Nature

Best Publications

  • Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.

    Beili Wu;Ellen Y. T. Chien;Clifford D. Mol;Gustavo Fenalti

  • Chemokine: receptor structure, interactions, and antagonism.

    Samantha J Allen;Susan E Crown;Tracy M Handel

  • Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines

    Amanda E. I. Proudfoot;Tracy M. Handel;Zoë Johnson;Elaine K. Lau

  • Regulation of protein function by glycosaminoglycans- : As exemplified by chemokines

    T M Handel;Z Johnson;S E Crown;E K Lau

  • The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

    Morgan O'Hayre;José Vázquez-Prado;Irina Kufareva;Eric W. Stawiski

  • Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades.

    Brian A. Zabel;Brian A. Zabel;Samantha J. Allen;Paulina Kulig;Jessica A. Allen;Jessica A. Allen

  • De novo design of the hydrophobic cores of proteins.

    John R. Desjarlais;Tracy M. Handel

  • Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH

    Aaron K. Chamberlain;Tracy M. Handel;Susan Marqusee

  • Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

    Ling Qin;Irina Kufareva;Lauren G. Holden;Chong Wang

  • Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis

    Brian A. Zabel;Susumu Nakae;Luis Zúñiga;Ji-Yun Kim

  • Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment.

    Morgan O'Hayre;Catherina L. Salanga;Tracy M. Handel;Samantha J. Allen

  • Metal ion-dependent modulation of the dynamics of a designed protein

    Tracy M. Handel;Scott A. Williams;William F. DeGrado;William F. DeGrado

  • Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention.

    Z. Johnson;A.E. Proudfoot;T.M. Handel

  • Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists

    Yi Zheng;Ling Qin;Natalia V. Ortiz Zacarías;Henk de Vries

  • Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo.

    Elaine K. Lau;Chad D. Paavola;Zoë Johnson;Jean-Philippe Gaudry

  • De novo design of the hydrophobic core of ubiquitin.

    Greg A. Lazar;John R. Desjarlais;Tracy M. Handel

  • Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2B

    Chad D. Paavola;Stefan Hemmerich;Dorit Grunberger;Irene Polsky

  • Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.

    Irina Kufareva;Catherina L Salanga;Tracy M Handel

  • Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo.

    J A Hedrick;V Saylor;D Figueroa;L Mizoue

  • Energy functions for protein design: adjustment with protein-protein complex affinities, models for the unfolded state, and negative design of solubility and specificity.

    Navin Pokala;Tracy M. Handel

Frequent Co-Authors

Eugene C. Butcher
Eugene C. Butcher Stanford University
Ruben Abagyan
Ruben Abagyan University of California, San Diego
Amanda E. I. Proudfoot
Amanda E. I. Proudfoot Merck (Germany)
Yi Zheng
Yi Zheng Cincinnati Children's Hospital Medical Center
John R. Desjarlais
John R. Desjarlais Pennsylvania State University
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Anthony J. Day
Anthony J. Day University of Manchester
Brian F. Volkman
Brian F. Volkman Medical College of Wisconsin
Thomas J. Kipps
Thomas J. Kipps University of California, San Diego
William F. DeGrado
William F. DeGrado University of California, San Francisco

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