World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
17042
World Ranking
8593
National Ranking
3860

Overview

Brian F. Volkman is affiliated with the Medical College of Wisconsin in the United States. Their research spans multiple interconnected fields within the life sciences, focusing primarily on Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. These areas are supported by a substantial body of work, including 94 publications related to Biochemistry, Genetics and Molecular Biology, 63 in Medicine, and 45 in Immunology and Microbiology.

The molecular aspects of their research are highlighted by significant contributions to subfields such as Molecular Biology, Immunology, Oncology, Radiology, Nuclear Medicine and Imaging, and Microbiology. These subfields underscore a broad engagement in both fundamental and applied biomedical science.

Key topics explored by Volkman include chemokine receptors and signaling, immunotherapy and immune responses, monoclonal and polyclonal antibodies research, T-cell and B-cell immunology, protein structure and dynamics, glycosylation and glycoproteins research, and antimicrobial peptides and activities. This range of topics reflects a diverse focus on cellular communication, immune system function, and protein biology.

Among recent publications are several papers with high visibility in well-regarded journals:

  • Evolution of fold switching in a metamorphic protein, 2020, Science
  • Rapid biosensor development using plant hormone receptors as reprogrammable scaffolds, 2022, Nature Biotechnology
  • Design of stimulus-responsive two-state hinge proteins, 2023, Science
  • A negative-feedback loop maintains optimal chemokine concentrations for directional cell migration, 2020, Nature Cell Biology
  • Tumor Derived Extracellular Vesicles Drive T Cell Exhaustion in Tumor Microenvironment through Sphingosine Mediated Signaling and Impacting Immunotherapy Outcomes in Ovarian Cancer, 2022, Advanced Science

Volkman frequently collaborates with a group of coauthors including Francis C. Peterson, Acacia F. Dishman, Davin R. Jensen, Brian C. Smith, and Angela Mathison. These collaborations have resulted in multiple joint publications contributing to the depth and breadth of their scientific output.

Their work has appeared in a variety of publication venues, with notable repeat contributions to The FASEB Journal, bioRxiv (Cold Spring Harbor Laboratory), Science, Proceedings of the National Academy of Sciences, and the Journal of Biological Chemistry. This range of journals indicates active engagement with both broad and specialized audiences in the biomedical sciences.

Best Publications

  • Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins

    Sang-Youl Park;Pauline Fung;Noriyuki Nishimura;Davin R. Jensen

  • A gate–latch–lock mechanism for hormone signalling by abscisic acid receptors

    Karsten Melcher;Ley-Moy Ng;Ley-Moy Ng;X. Edward Zhou;Fen-Fen Soon;Fen-Fen Soon

  • Two-state allosteric behavior in a single-domain signaling protein.

    Brian F. Volkman;Doron Lipson;David E. Wemmer;Dorothee Kern

  • Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

    Christopher T. Veldkamp;Christoph Seibert;Francis C. Peterson;Norberto B. De la Cruz

  • Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance

    Masanori Okamoto;Masanori Okamoto;Francis C. Peterson;Andrew Defries;Sang-Youl Park

  • Interconversion between two unrelated protein folds in the lymphotactin native state

    Robbyn L. Tuinstra;Francis C. Peterson;Snjezana Kutlesa;E. Sonay Elgin

  • Structural and functional insights into core ABA signaling.

    Joshua J Weiner;Francis C Peterson;Brian F Volkman;Sean R Cutler

  • Agrochemical control of plant water use using engineered abscisic acid receptors

    Sang-Youl Park;Francis C. Peterson;Assaf Mosquna;Assaf Mosquna;Jin Yao

  • Structure of a transiently phosphorylated switch in bacterial signal transduction

    Dorothee Kern;Brian F. Volkman;Peter Luginbühl;Michael J. Nohaile

  • Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways.

    Luke J. Drury;Joshua J. Ziarek;Stéphanie Gravel;Christopher T. Veldkamp;Christopher T. Veldkamp

  • The monomer-dimer equilibrium of stromal cell-derived factor-1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin.

    Christopher T. Veldkamp;Francis C. Peterson;Adam J. Pelzek;Brian F. Volkman

  • Structure of the N-WASP EVH1 Domain-WIP Complex: Insight into the Molecular Basis of Wiskott-Aldrich Syndrome

    Brian F. Volkman;Kenneth E. Prehoda;Jessica A. Scott;Francis C. Peterson

  • Microscopic pKa values of Escherichia coli thioredoxin.

    Peter T. Chivers;Kenneth E. Prehoda;Brian F. Volkman;Byung-Moon Kim

  • Cdc42 Regulates the Par-6 PDZ Domain through an Allosteric CRIB-PDZ Transition

    Francis C. Peterson;Rhiannon R. Penkert;Brian F. Volkman;Kenneth E. Prehoda

  • Polysialylation controls dendritic cell trafficking by regulating chemokine recognition.

    Eva Kiermaier;Christine Moussion;Christopher T. Veldkamp;Christopher T. Veldkamp;Rita Gerardy-Schahn

  • Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4.

    Michael M. Mysinger;Dahlia R. Weiss;Joshua J. Ziarek;Stéphanie Gravel

  • Three-dimensional solution structure of the N-terminal receiver domain of NTRC.

    Brian F. Volkman;Michael J. Nohaile;Nancy K. Amy;Sydney Kustu

  • Cell-free protein production and labeling protocol for NMR-based structural proteomics.

    Dmitriy A Vinarov;Betsy L Lytle;Betsy L Lytle;Francis C Peterson;Francis C Peterson;Ejan M Tyler

  • Recognition of a CXCR4 Sulfotyrosine by the Chemokine Stromal Cell-derived Factor-1α (SDF-1α/CXCL12)

    Christopher T. Veldkamp;Christoph Seibert;Francis C. Peterson;Thomas P. Sakmar

  • Dynamic control of plant water use using designed ABA receptor agonists

    Aditya S. Vaidya;Jonathan D. M. Helander;Francis C. Peterson;Dezi Elzinga

Frequent Co-Authors

John L. Markley
John L. Markley University of Wisconsin–Madison
George N. Phillips
George N. Phillips Rice University
David E. Wemmer
David E. Wemmer University of California, Berkeley
Brian G. Fox
Brian G. Fox University of Wisconsin–Madison
Sean R. Cutler
Sean R. Cutler University of California, Riverside
Samuel T Hwang
Samuel T Hwang University of California, Davis
Paolo Lusso
Paolo Lusso National Institutes of Health
Tracy M. Handel
Tracy M. Handel University of Montana
Isabel Moura
Isabel Moura Universidade Nova de Lisboa
José J. G. Moura
José J. G. Moura Universidade Nova de Lisboa

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