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Mette M. Rosenkilde

Mette M. Rosenkilde

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
19652
World Ranking
6271
National Ranking
56

Overview

Mette M. Rosenkilde is affiliated with the University of Copenhagen in Denmark. Their research spans several interconnected areas within medicine and biochemistry, focusing particularly on endocrinology, diabetes, and metabolism.

Their work primarily addresses the mechanisms and therapeutic potential of receptor signaling in diabetes treatment, with a strong emphasis on pancreatic function. They explore molecular interactions related to neuropeptides and chemokine receptors, as well as broader topics at the intersection of metabolism, diabetes, and cancer.

The main fields of study associated with Rosenkilde include:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, the subfields of study cover:

  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Oncology
  • Cellular and Molecular Neuroscience

Their research topics further extend to:

  • Diabetes Treatment and Management
  • Receptor Mechanisms and Signaling
  • Pancreatic function and diabetes
  • Neuropeptides and Animal Physiology
  • Metabolism, Diabetes, and Cancer
  • Chemokine receptors and signaling
  • Cytomegalovirus and herpesvirus research

Rosenkilde has contributed to multiple scholarly articles, with recent papers including:

  • "Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist," 2020, JCI Insight
  • "GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists," 2020, The Journal of Clinical Endocrinology & Metabolism
  • "Dendritic Cells and CCR7 Expression: An Important Factor for Autoimmune Diseases, Chronic Inflammation, and Cancer," 2021, International Journal of Molecular Sciences
  • "GLP-1 and GIP receptor signaling in beta cells - A review of receptor interactions and co-stimulation," 2022, Peptides
  • "The Role of Incretins on Insulin Function and Glucose Homeostasis," 2021, Endocrinology

Their collaborative network includes frequent coauthors such as:

  • Jens J. Holst
  • Bolette Hartmann
  • Lærke S. Gasbjerg
  • Filip K. Knop
  • Alexander H. Sparre-Ulrich

In terms of publication venues, Rosenkilde has regularly published in:

  • British Journal of Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Clinical Endocrinology & Metabolism
  • ACS Pharmacology & Translational Science
  • Communications Biology

Best Publications

  • International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

    Francoise Bachelerie;Adit Ben-Baruch;Amanda M. Burkhardt;Christophe Combadiere

  • Potent Inhibition of HIV-1 Infectivity in Macrophages and Lymphocytes by a Novel CCR5 Antagonist

    Graham Simmons;Paul R. Clapham;Laurent Picard;Robin E. Offord

  • A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus

    Thomas N. Kledal;Mette M. Rosenkilde;Florence Coulin;Graham Simmons

  • MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL

    Thue W Schwartz;Thomas M Frimurer;Birgitte Holst;Mette M Rosenkilde

  • Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

    Natalie Signoret;Joanne Oldridge;Annegret Pelchen-Matthews;Per J. Klasse

  • Ligand binding and micro-switches in 7TM receptor structures

    Rie Nygaard;Thomas M. Frimurer;Birgitte Holst;Mette M. Rosenkilde

  • The chemokine system -- a major regulator of angiogenesis in health and disease.

    Mette M. Rosenkilde;Thue W. Schwartz

  • The impact of short chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

    Charlotte Bayer Christiansen;Maria Buur Nordskov Gabe;Berit Svendsen;Lars Ove Dragsted

  • Molecular Mechanism of AMD3100 Antagonism in the CXCR4 Receptor: TRANSFER OF BINDING SITE TO THE CXCR3 RECEPTOR

    Mette M. Rosenkilde;Lars-Ole Gerlach;Janus S. Jakobsen;Renato T. Skerlj

  • 2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.

    Katrine B. Hansen;Mette M. Rosenkilde;Filip K. Knop;Niels Wellner

  • Insulin Secretion Depends on Intra-islet Glucagon Signaling

    Berit Svendsen;Olav Larsen;Maria Buur Nordskov Gabe;Charlotte Bayer Christiansen

  • Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28

    Thomas N Kledal;Mette M Rosenkilde;Thue W Schwartz

  • Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

    Francis S. Willard;Jonathan D. Douros;Maria B.N. Gabe;Aaron D. Showalter

  • Agonists and Inverse Agonists for the Herpesvirus 8-encoded Constitutively Active Seven-transmembrane Oncogene Product, ORF-74

    Mette M. Rosenkilde;Thomas N. Kledal;Hans Bräuner-Osborne;Thue W. Schwartz

  • Physical activity plays an important role in body weight regulation.

    Jean-Philippe Chaput;Lars Klingenberg;Mads Rosenkilde;Jo-Anne Gilbert

  • GPR119 as a fat sensor

    Harald S Hansen;Mette M Rosenkilde;Jens Juul Holst;Thue W Schwartz

  • Biased and G Protein-Independent Signaling of Chemokine Receptors

    Anne Steen;Olav Larsen;Stefanie Thiele;Mette M. Rosenkilde

  • Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

    Rune E Kuhre;Nicolai J Wewer Albrechtsen;Olav Larsen;Sara L Jepsen

  • Differential regulation of CXCR4 and CCR5 endocytosis

    N. Signoret;M.M. Rosenkilde;P.J. Klasse;T.W. Schwartz

  • Body fat loss and compensatory mechanisms in response to different doses of aerobic exercise—a randomized controlled trial in overweight sedentary males

    Mads Rosenkilde;Pernille Landrock Auerbach;Michala Holm Reichkendler;Thorkil Ploug

Frequent Co-Authors

Jens J. Holst
Jens J. Holst University of Copenhagen
Thue W. Schwartz
Thue W. Schwartz University of Copenhagen
Filip K. Knop
Filip K. Knop University of Copenhagen
Trond Ulven
Trond Ulven University of Copenhagen
Sten Madsbad
Sten Madsbad University of Copenhagen
Carolyn F. Deacon
Carolyn F. Deacon University of Copenhagen
Harald S. Hansen
Harald S. Hansen University of Copenhagen
Christian Berg
Christian Berg University of Copenhagen
Gary J. Bridger
Gary J. Bridger Liminal BioSciences (Canada)

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