World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
16138
World Ranking
14201
National Ranking
494

Overview

Gary J. Bridger is affiliated with Liminal BioSciences in Canada, where they contribute to medical research with a focus on several specialized fields.

The primary areas of study in Bridger's work include Medicine, with significant contributions across Oncology, Hematology, and Immunology and Allergy. Their research projects also cover key topics such as Chemokine receptors and signaling, Platelet Disorders and Treatments, and Cell Adhesion Molecules Research.

Among Bridger's recent scholarly output is a 2024 publication titled A phase 3 randomized trial of mavorixafor, a CXCR4 antagonist, for WHIM syndrome appearing in the journal Blood.

Frequent co-authors in Bridger's publications are:

  • Raffaele Badolato
  • Laia Alsina
  • Antoine Azar
  • Yves Bertrand
  • Audrey Anna Bolyard

In terms of publication venues, Bridger has concentrated efforts within the journal Blood, marking it as a notable platform for disseminating research findings.

The scope of Bridger's work spans investigations into molecular and cellular mechanisms underlying diseases relating to immunity and blood disorders. This includes targeted studies on receptors that mediate chemokine signaling pathways and the biological factors influencing platelet function and cell adhesion.

Best Publications

  • Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

    Hal E. Broxmeyer;Christie M. Orschell;D. Wade Clapp;Giao Hangoc

  • Phase III prospective randomized double-blind placebo-controlled trial of plerixafor plus granulocyte colony-stimulating factor compared with placebo plus granulocyte colony-stimulating factor for autologous stem-cell mobilization and transplantation for patients with non-Hodgkin's lymphoma.

    John F. DiPersio;Ivana N. Micallef;Patrick J. Stiff;Brian J. Bolwell

  • Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist.

    W. Conrad Liles;W. Conrad Liles;Hal E. Broxmeyer;Hal E. Broxmeyer;Elin Rodger;Elin Rodger;Brent Wood;Brent Wood

  • Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer

    Chris J. Scotton;Julia L. Wilson;Kate Scott;Gordon Stamp

  • Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4.

    Sigrid Hatse;Katrien Princen;Gary Bridger;Erik De Clercq

  • Pharmacokinetics and Safety of AMD-3100, a Novel Antagonist of the CXCR-4 Chemokine Receptor, in Human Volunteers

    Craig W. Hendrix;Charles Flexner;Ronald T. MacFarland;Christen Giandomenico

  • Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100

    Bruno Nervi;Pablo Ramirez;Michael P. Rettig;Geoffrey L. Uy

  • Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection

    Craig W. Hendrix;Ann C. Collier;Michael Marcel Lederman;Dominique Schols

  • AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.

    Patrick Matthys;Sigrid Hatse;Kurt Vermeire;Anja Wuyts

  • Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor.

    Lars Ole Gerlach;Renato T. Skerlj;Gary J. Bridger;Thue W. Schwartz

  • Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.

    E De Clercq;N Yamamoto;R Pauwels;J Balzarini

  • Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)-Linked Bis-Tetraazamacrocycles That Inhibit HIV Replication. Effects of Macrocyclic Ring Size and Substituents on the Aromatic Linker

    Gary J. Bridger;Renato T. Skerlj;David Thornton;Sreenivasan Padmanabhan

  • Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

    E De Clercq;N Yamamoto;R Pauwels;M Baba

  • AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.

    Nicholas W. Lukacs;Aaron Berlin;Dominique Schols;Renato T. Skerlj

  • Molecular Mechanism of AMD3100 Antagonism in the CXCR4 Receptor: TRANSFER OF BINDING SITE TO THE CXCR3 RECEPTOR

    Mette M. Rosenkilde;Lars-Ole Gerlach;Janus S. Jakobsen;Renato T. Skerlj

  • AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates

    André Larochelle;Allen Krouse;Mark Metzger;Donald Orlic

  • Comparison of the potential multiple binding modes of bicyclam, monocylam, and noncyclam small-molecule CXC chemokine receptor 4 inhibitors.

    Rebecca S. Y. Wong;Veronique Bodart;Markus Metz;Jean Labrecque

  • Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

    Gary J. Bridger;Renato T. Skerlj;Sreenivasan Padmanabhan;Stephen A. Martellucci

  • AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

    Sigrid Hatse;Katrien Princen;Erik De Clercq;Mette M. Rosenkilde

  • Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

    Mette M. Rosenkilde;Lars Ole Gerlach;Sigrid Hatse;Renato T. Skerlj

Frequent Co-Authors

Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Thue W. Schwartz
Thue W. Schwartz University of Copenhagen
Louis M. Pelus
Louis M. Pelus Indiana University
John F. DiPersio
John F. DiPersio Washington University in St. Louis
Mette M. Rosenkilde
Mette M. Rosenkilde University of Copenhagen
David C. Dale
David C. Dale University of Washington
Giao Hangoc
Giao Hangoc Indiana University

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Best Scientists Citing Gary J. Bridger