Hirokazu Tamamura

Overview

Best Publications

• Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5.

  Christopher D C Allen;K Mark Ansel;K Mark Ansel;Caroline Low;Robin Lesley

  958
  Citations

• A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line–tropic HIV-1 Infection

  Tsutomu Murakami;Toshihiro Nakajima;Yoshio Koyanagi;Kazunobu Tachibana

  592
  Citations

• A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.

  Hirokazu Tamamura;Younong Xu;Toshio Hattori;Xiaoyan Zhang

  452
  Citations

• T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer

  Hirokazu Tamamura;Akira Hori;Naoyuki Kanzaki;Kenichi Hiramatsu

  435
  Citations

• Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells

  Meike Burger;Tanja Hartmann;Tanja Hartmann;Myriam Krome;Myriam Krome;Justyna Rawluk;Justyna Rawluk

  368
  Citations

• Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers

  Yann Percherancier;Yamina A. Berchiche;Isabelle Slight;Rudolf Volkmer-Engert

  346
  Citations

• HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus.

  Norio Yamamoto;Rongge Yang;Yoshiyuki Yoshinaka;Shinji Amari

  341
  Citations

• CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells.

  Kenji Kabashima;Noriko Shiraishi;Kazunari Sugita;Tomoko Mori

  303
  Citations

• A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.

  Wen-bo Zhang;Jean-Marc Navenot;Bodduluri Haribabu;Hirokazu Tamamura

  296
  Citations

• Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

  Nobutaka Fujii;Shinya Oishi;Kenichi Hiramatsu;Takanobu Araki

  292
  Citations

• Elevated Serum Levels of Stromal-Derived Factor-1α Are Associated with Increased Osteoclast Activity and Osteolytic Bone Disease in Multiple Myeloma Patients

  Andrew C.W. Zannettino;Amanda N. Farrugia;Angela Kortesidis;Jim Manavis

  256
  Citations

• Remodeling of gp41‐C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV‐1 with Target Cells

  Akira Otaka;Miki Nakamura;Daisuke Nameki;Eiichi Kodama

  217
  Citations

• A novel anti-HIV synthetic peptide, T-22 ([Tyr5,12,Lys7]-polyphemusin II)

  Masao Masuda;Hideki Nakashima;Toshihiro Ueda;Hiroyasu Naba

  197
  Citations

• Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent.

  Hirokazu Tamamura;Miho Fujisawa;Kenichi Hiramatsu;Makiko Mizumoto

  196
  Citations

• T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure

  Rieko Arakaki;Hirokazu Tamamura;Mariappan Premanathan;Kenji Kanbara

  195
  Citations

• Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells.

  Hui Peng;Yunlong Huang;Jeremy Rose;David Erichsen

  184
  Citations

• Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes.

  Hirokazu Tamamura;Akane Omagari;Shinya Oishi;Taisei Kanamoto

  180
  Citations

• Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists.

  John O. Trent;Zi-xuan Wang;James L. Murray;Wenhai Shao

  179
  Citations

• Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140.

  Hirokazu Tamamura;Akane Omagari;Kenichi Hiramatsu;Kazuyo Gotoh

  175
  Citations

• A comparative study of the solution structures of tachyplesin I and a novel anti-HIV synthetic peptide, T22 ([Tyr5,12, Lys7]-polyphemusin II), determined by nuclear magnetic resonance.

  Hirokazu Tamamura;Masataka Kuroda;Masao Masuda;Akira Otaka

  156
  Citations