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Biology and Biochemistry

D-Index
71
Citations
22613
World Ranking
6554
National Ranking
3052

Overview

Stephen C. Peiper is affiliated with Thomas Jefferson University in the United States and has contributed to research across Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans molecular biology, infectious diseases, genetics, neurology, and immunology, with a strong focus on both clinical and molecular aspects of disease.

Their recent scientific publications cover diverse topics including COVID-19, cancer biology, and molecular diagnostics. Notable papers include:

  • Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke (2020) published in Journal of Neurology Neurosurgery & Psychiatry
  • Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway (2022) published in Journal of Experimental & Clinical Cancer Research
  • S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer (2020) published in Oncogene
  • Commercial Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Molecular Assays: Superior Analytical Sensitivity of cobas SARS-CoV-2 Relative to NxTAG CoV Extended Panel and ID NOW COVID-19 Test (2020) published in Archives of Pathology & Laboratory Medicine
  • Characterization and Clinical Significance of EIF1AX Mutations and Co-Mutations (2021) published in Acta Medica Academica

Frequent co-authors collaborating with Stephen C. Peiper include:

  • Zixuan Wang
  • Shaomin Wang
  • Jun He
  • Timothy Chao
  • Wilbur B. Bowne

Stephen C. Peiper's work has been published predominantly in the following venues:

  • Journal of Experimental & Clinical Cancer Research
  • Archives of Pathology & Laboratory Medicine
  • Journal of Neurology Neurosurgery & Psychiatry
  • Oncogene
  • Acta Medica Academica

Their research interests focus extensively on the following topics:

  • COVID-19 Clinical Research Studies
  • PI3K/AKT/mTOR signaling in cancer
  • Long-Term Effects of COVID-19
  • Retinal and Optic Conditions
  • Extracellular vesicles in disease
  • Immune cells in cancer
  • Nanoplatforms for cancer theranostics

Stephen C. Peiper's multidisciplinary approach integrates studies on molecular mechanisms, clinical infectious diseases, and oncologic pathways. Their work in molecular biology and genetics supports understanding of disease mechanisms, particularly in relation to COVID-19 and cancer resistance.

Best Publications

  • Identification of a major co-receptor for primary isolates of HIV-1

    H Deng;R Liu;W Ellmeier;S Choe

  • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.

    Benjamin J Doranz;Joseph Rucker;Yanjie Yi;Robert J Smyth

  • Expression of chemokine receptors by subsets of neurons in the central nervous system.

    R. Horuk;A. W. Martin;Z.-X. Wang;L. Schweitzer

  • CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.

    Jolanta Libura;Justyna Drukala;Marcin Majka;Oana Tomescu

  • CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.

    Joseph Hesselgesser;Meredith Halks-Miller;Virginia DelVecchio;Stephen C. Peiper

  • From Malaria to Chemokine Receptor: The Emerging Physiologic Role of the Duffy Blood Group Antigen

    Terence J. Hadley;Stephen C. Peiper

  • Expression of functional CXCR4 by muscle satellite cells and secretion of SDF-1 by muscle-derived fibroblasts is associated with the presence of both muscle progenitors in bone marrow and hematopoietic stem/progenitor cells in muscles.

    Mariusz Z. Ratajczak;Marcin Majka;Magda Kucia;Justyna Drukala

  • Unwelcomed Guests With Master Keys: How HIV Uses Chemokine Receptors for Cellular Entry

    Robert W. Doms;Stephen C. Peiper

  • Regulation of human chemokine receptors CXCR4: Role of phosphorylation in desensitization and internalization

    Bodduluri Haribabu;Ricardo M. Richardson;Ian Fisher;Silvano Sozzani

  • The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

    S. C. Peiper;Zi-Xuan Wang;K. Neote;A. W. Martin

  • Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.

    B J Doranz;Z H Lu;J Rucker;T Y Zhang

  • Identification of CXCR4 Domains That Support Coreceptor and Chemokine Receptor Functions

    Benjamin J. Doranz;Michael J. Orsini;Julie D. Turner;Trevor L. Hoffman

  • A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.

    Wen-bo Zhang;Jean-Marc Navenot;Bodduluri Haribabu;Hirokazu Tamamura

  • Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

    Nobutaka Fujii;Shinya Oishi;Kenichi Hiramatsu;Takanobu Araki

  • Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains

    Aimee L. Edinger;Angela Amedee;Karen Miller;Benjamin J. Doranz

  • Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen.

    T. J. Hadley;Zhao-Hai Lu;K. Wasniowska;A. W. Martin

  • Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and prototype isolates resulting from the delta ccr5 mutation.

    Shalini Rana;Gideon Besson;David G. Cook;Joseph Rucker

  • Status of SARS-CoV-2 in cerebrospinal fluid of patients with COVID-19 and stroke.

    Fadi Al Saiegh;Ritam Ghosh;Adam Leibold;Michael B. Avery

  • Both Hepatocyte Growth Factor (HGF) and Stromal-Derived Factor-1 Regulate the Metastatic Behavior of Human Rhabdomyosarcoma Cells, But Only HGF Enhances Their Resistance to Radiochemotherapy

    Kacper Jankowski;Magda Kucia;Marcin Wysoczynski;Ryan Reca

  • Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC)

    Tracey C. Dawson;Alex B. Lentsch;Alex B. Lentsch;Alex B. Lentsch;Zixuan Wang;Zixuan Wang;Zixuan Wang;John E. Cowhig;John E. Cowhig;John E. Cowhig

Frequent Co-Authors

Nobutaka Fujii
Nobutaka Fujii Kyoto University
Hirokazu Tamamura
Hirokazu Tamamura Tokyo Medical and Dental University
Shinya Oishi
Shinya Oishi Kyoto University
John O. Trent
John O. Trent University of Louisville
Naoki Yamamoto
Naoki Yamamoto Kyoto University
Akira Otaka
Akira Otaka University of Tokushima
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University
Hiroaki Ohno
Hiroaki Ohno Kyoto University
James R. Broach
James R. Broach Pennsylvania State University
Leonard G. Gomella
Leonard G. Gomella Thomas Jefferson University

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