World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
94
Citations
32588
World Ranking
934
National Ranking
461

Molecular Biology

D-Index
94
Citations
32588
World Ranking
656
National Ranking
359

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1994 - Fellow of the American Academy of Microbiology Molecular, Cellular and General Biology of Eukaryotes

Overview

James R. Broach is affiliated with Pennsylvania State University in the United States. Their research spans multiple fields, primarily focusing on Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader fields, their work delves further into various subfields including Molecular Biology, Genetics, Neurology, Pediatrics, Perinatology and Child Health, as well as Cancer Research.

The scientist's research covers a range of topics, prominently including Amyotrophic Lateral Sclerosis Research, Acute Myeloid Leukemia Research, Genomics and Phylogenetic Studies, Cancer Genomics and Diagnostics, Neurogenetic and Muscular Disorders Research, Gut Microbiota and Health, and Vibrio Bacteria Research Studies.

James R. Broach has co-authored numerous papers with frequent collaborators such as Christine Hehnly, Steven J. Schiff, Joseph N. Paulson, Jessica E. Ericson, and Lijun Zhang. These co-authors have appeared repeatedly over multiple publications, indicating ongoing research partnerships.

The scientist has published extensively in various venues. The most frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Nature, SSRN Electronic Journal, iScience, and the Journal of Personalized Medicine.

Some recent papers authored or co-authored by James R. Broach include:

  • TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A, 2022, Nature
  • Congenital Cytomegalovirus Infection Burden and Epidemiologic Risk Factors in Countries With Universal Screening, 2021, JAMA Network Open
  • Subtype-specific 3D genome alteration in acute myeloid leukaemia, 2022, Nature
  • An integrative ENCODE resource for cancer genomics, 2020, Nature Communications
  • Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus, 2020, Nature Medicine

James R. Broach has received recognition from professional organizations, including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2013. Earlier, in 1994, they were designated a Fellow of the American Academy of Microbiology for contributions in Molecular, Cellular and General Biology of Eukaryotes.

Best Publications

  • Transformation in yeast: Development of a hybrid cloning vector and isolation of the can1 gene

    James R. Broach;Jeffrey N. Strathern;James B. Hicks

  • In yeast, RAS proteins are controlling elements of adenylate cyclase

    Takashi Toda;Isao Uno;Tatsuo Ishikawa;Scott Powers

  • Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

    M Braunstein;A B Rose;S G Holmes;C D Allis

  • The Molecular biology of the yeast saccharomyces, life cycle and inheritance

    Jeffrey N. Strathern;Elizabeth W. Jones;James R. Broach

  • The Molecular biology of the yeast Saccharomyces : metabolism and gene expression

    Jeffrey N. Strathern;Elizabeth W. Jones;James R. Broach

  • Sch9 is a major target of TORC1 in Saccharomyces cerevisiae

    Jörg Urban;Alexandre Soulard;Alexandre Huber;Soyeon Lippman

  • Nutritional Control of Growth and Development in Yeast

    James R. Broach

  • A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size

    Paul Jorgensen;Ivan Rupeš;Jeffrey R. Sharom;Lisa Schneper

  • How Saccharomyces Responds to Nutrients

    Shadia Zaman;Soyeon Im Lippman;Xin Zhao;James R. Broach

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Genetic analysis of yeast RAS1 and RAS2 genes.

    T. Kataoka;S. Powers;C. McGill;O. Fasano

  • Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern.

    M Braunstein;R E Sobel;C D Allis;B M Turner

  • Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins.

    S. Powers;T. Kataoka;O. Fasano;M. Goldfarb

  • Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

    Yu Jiang;James R. Broach

  • Localization and sequence analysis of yeast origins of DNA replication.

    James Broach;Y. Y. Li;J. Feldman;M. Jayaram

  • High-throughput screening for drug discovery.

    James R. Broach;Jeremy Thorner

  • Functional homology of mammalian and yeast RAS genes

    Tohru Kataoka;Scott Powers;Scott Cameron;Ottavio Fasano

  • Integrative detection and analysis of structural variation in cancer genomes

    Jesse R. Dixon;Jie Xu;Vishnu Dileep;Ye Zhan

  • Replication and recombination functions associated with the yeast plasmid, 2μ circle

    James R. Broach;James B. Hicks

  • Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

Frequent Co-Authors

David M. Goldenberg
David M. Goldenberg Immunomedics (United States)
Steven J. Schiff
Steven J. Schiff Yale University
James W. Hicks
James W. Hicks University of Southern California
Jeffrey N. Strathern
Jeffrey N. Strathern National Institutes of Health
Stephen C. Peiper
Stephen C. Peiper Thomas Jefferson University
Nobutaka Fujii
Nobutaka Fujii Kyoto University
Michael Wigler
Michael Wigler Cold Spring Harbor Laboratory
David M. Gilbert
David M. Gilbert Florida State University
Job Dekker
Job Dekker University of Massachusetts Chan Medical School
Andrew J. Murphy
Andrew J. Murphy St. Jude Children's Research Hospital

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