2026 Michael Wigler: Molecular Biology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Genetics	130	254	245	135	130	332	86947
Molecular Biology	130	188	169	117	105	332	86947

Research.com Recognitions

2025 - Research.com Molecular Biology in United States Leader Award
1999 - Fellow of the American Academy of Arts and Sciences
1989 - Member of the National Academy of Sciences

Overview

Michael Wigler is affiliated with Cold Spring Harbor Laboratory in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with particular emphasis on Molecular Biology, Cancer Research, Genetics, Hematology, and Oncology. Their work extensively covers topics such as Cancer Genomics and Diagnostics, Single-cell and Spatial Transcriptomics, Genomic Variations and Chromosomal Abnormalities, Molecular Biology Techniques and Applications, Acute Myeloid Leukemia Research, Autism Spectrum Disorder Research, and Genomics and Phylogenetic Studies.

Wigler's recent publications demonstrate a focus on cancer biology, genetic heterogeneity, and genomic mechanisms in disease progression. Notable papers include:

Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes (2020, Cancer Discovery)
Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer (2020, Developmental Cell)
Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing (2020, eLife)
Rates of contributory de novo mutation in high and low-risk autism families (2021, Communications Biology)
Dietary pro-oxidant therapy by a vitamin K precursor targets PI 3-kinase VPS34 function (2024, Science)

The scientist frequently collaborates with other researchers, with prominent coauthors including Dan Levy, Jude Kendall, Zihua Wang, Peter Andrews, and Joan Alexander. These collaborations often contribute to publications in well-recognized scientific venues.

Wigler has published multiple works in high-impact journals, with repeated contributions to Nucleic Acids Research, bioRxiv (Cold Spring Harbor Laboratory), Blood, Zenodo (CERN European Organization for Nuclear Research), and Gynecologic Oncology. This range reflects engagement with both preprint and peer-reviewed platforms across molecular biology and oncology disciplines.

Their membership and accolades include being named a Member of the National Academy of Sciences since 1989 and a Fellow of the American Academy of Arts and Sciences since 1999, indicating longstanding recognition by the scientific community.

Best Publications

PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Jing Li;Clifford Yen;Danny Liaw;Katrina Podsypanina

7086
Citations
Strong Association of De Novo Copy Number Mutations with Autism

Jonathan Sebat;B. Lakshmi;Dheeraj Malhotra;Jennifer Troge

3454
Citations
Large-Scale Copy Number Polymorphism in the Human Genome

Jonathan Sebat;B. Lakshmi;Jennifer Troge;Joan Alexander

3098
Citations
Tumour evolution inferred by single-cell sequencing

Nicholas E Navin;Jude Kendall;Jennifer Troge;Peter M Andrews

2899
Citations
The contribution of de novo coding mutations to autism spectrum disorder

Ivan Iossifov;Brian J. O'Roak;Stephan J. Sanders;Stephan J. Sanders;Michael Ronemus

2836
Citations
Circular binary segmentation for the analysis of array-based DNA copy number data.

Adam B. Olshen;E. S. Venkatraman;Robert Lucito;Michael Wigler

2673
Citations
Cloning the differences between two complex genomes.

N. Lisitsyn;M. H. Wigler

1899
Citations
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.

Michael Wigler;Saul Silverstein;Lih-Syng Lee;Angel Pellicer

1763
Citations
De Novo Gene Disruptions in Children on the Autistic Spectrum

Ivan Iossifov;Michael Ronemus;Dan Levy;Zihua Wang

1694
Citations
Transformation of mammalian cells with genes from procaryotes and eucaryotes

Michael Wigler;Raymond Sweet;Gek Kee Sim;Barbara Wold

1605
Citations
The lipid phosphatase activity of PTEN is critical for its tumor supressor function

M. P. Myers;I. Pass;I. H. Batty;J. Van der Kaay

1549
Citations
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

Michael Wigler;Angel Pellicer;Saul Silverstein;Richard Axel

1539
Citations
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

Michael Wigler;Angel Pellicer;Saul Silverstein;Richard Axel

1533
Citations
Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

J. Field;J. Nikawa;D. Broek;B. MacDonald

1313
Citations
In yeast, RAS proteins are controlling elements of adenylate cyclase

Takashi Toda;Isao Uno;Tatsuo Ishikawa;Scott Powers

1299
Citations
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

Lars. Zender;Mona S. Spector;Wen. Xue;Peer. Flemming

1243
Citations
Processes for inserting dna into eucaryotic cells and for producing proteinaceous materials

Richard Axel;Michael H. Wigler;Saul J. Silverstein

1240
Citations
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

Michael P. Myers;Javor P. Stolarov;Charis Eng;Jing Li

1125
Citations
Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.

P. Chardin;J. H. Camonis;N. W. Gale;L. Van Aelst

1062
Citations
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.

Roymarie Ballester;Douglas A. Marchuk;Douglas A. Marchuk;Mark Boguski;Ann M. Saulino;Ann M. Saulino

1036
Citations

Frequent Co-Authors

James W. Hicks University of Southern California

Mitchell Goldfarb Hunter College

Richard Axel Columbia University

Nicholas Navin The University of Texas MD Anderson Cancer Center

Jeffrey Field University of Pennsylvania

Manuel Perucho Discovery Institute

Jonathan Sebat University of California, San Diego

Anders Zetterberg Karolinska Institute

Saul Silverstein Columbia University

Scott W. Lowe Memorial Sloan Kettering Cancer Center

External Links

Wikipedia of Michael Wigler Personal website of Michael Wigler

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