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Biology and Biochemistry

D-Index
62
Citations
16604
World Ranking
10647
National Ranking
4626

Overview

Gregory D. Cuny is affiliated with the University of Houston in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with particular focus on subfields such as Molecular Biology, Organic Chemistry, Epidemiology, Infectious Diseases, and Materials Chemistry.

The scientist's work covers several main topics, including:

  • Biochemical and Molecular Research
  • Cell death mechanisms and regulation
  • Cytomegalovirus and herpesvirus research
  • NF-κB Signaling Pathways
  • Parasitic Infections and Diagnostics
  • Amoebic Infections and Treatments
  • Traditional and Medicinal Uses of Annonaceae

Gregory D. Cuny has contributed to a range of recent publications. Notable papers include:

  • "RIPK protein kinase family: Atypical lives of typical kinases," 2020, Seminars in Cell and Developmental Biology
  • "Necroptosis blockade prevents lung injury in severe influenza," 2024, Nature
  • "Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge," 2021, npj Vaccines
  • "Targeted Degradation of the Oncogenic Phosphatase SHP2," 2021, Biochemistry
  • "Current status and challenges in drug discovery against the globally important zoonotic cryptosporidiosis," 2021, Animal Diseases

The frequent co-authors collaborating with Gregory D. Cuny are:

  • Anantha Lakshmi Duddupudi
  • Lizbeth Hedstrom
  • Alexei Degterev
  • Seungheon Lee
  • Shibin Chacko

Frequent venues where Gregory D. Cuny's research has been published include:

  • Bioorganic & Medicinal Chemistry Letters
  • ACS Infectious Diseases
  • The Cambridge Structural Database
  • European Journal of Medicinal Chemistry
  • The Journal of Organic Chemistry

Best Publications

  • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

    Alexei Degterev;Zhihong Huang;Michael Boyce;Yaqiao Li

  • Identification of RIP1 kinase as a specific cellular target of necrostatins.

    Alexei Degterev;Junichi Hitomi;Megan Germscheid;Irene L Ch'en

  • BMP type I receptor inhibition reduces heterotopic ossification

    Paul B Yu;Donna Y Deng;Carol S Lai;Charles C Hong

  • Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.

    Gregory D. Cuny;Paul B. Yu;Joydev K. Laha;Xuechao Xing

  • Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage

    Xing Zeng;Frederic Sigoillot;Shantanu Gaur;Sungwoon Choi

  • Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

    Yichin Liu;Yichin Liu;Hilal A. Lashuel;Hilal A. Lashuel;Sungwoon Choi;Xuechao Xing

  • Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice

    Zerong You;Sean I Savitz;Sean I Savitz;Jinsheng Yang;Alexei Degterev

  • Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model.

    Daniel M. Rosenbaum;Alexei Degterev;Joel David;Pearl S. Rosenbaum

  • Structure-activity relationship study of novel necroptosis inhibitors.

    Xin Teng;Alexei Degterev;Prakash Jagtap;Xuechao Xing

  • A new class of small molecule inhibitor of BMP signaling.

    Caroline E. Sanvitale;Georgina Kerr;Apirat Chaikuad;Marie-Christine Ramel

  • A Mild, One‐Pot Stadler–Ziegler Synthesis of Arylsulfides Facilitated by Photoredox Catalysis in Batch and Continuous‐Flow

    Xiao Wang;Gregory D. Cuny;Gregory D. Cuny;Timothy Noël

  • Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

    Helena Mistry;Grace Hsieh;Sara J. Buhrlage;Min Huang

  • Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.

    Andrea U. Steinbicker;Chetana Sachidanandan;Ashley J. Vonner;Rushdia Z. Yusuf

  • Development of an ALK2-biased BMP type I receptor kinase inhibitor

    Agustin H. Mohedas;Xuechao Xing;Kelli A. Armstrong;Alex N. Bullock

  • Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

    Qiongman Kong;Ling-Chu Chang;Kou Takahashi;Qibing Liu

  • Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

    Kou Takahashi;Qiongman Kong;Yuchen Lin;Nathan Stouffer

  • Structure-activity relationship study of novel tissue transglutaminase inhibitors

    Eric Duval;April Case;Ross L. Stein;Gregory D. Cuny

  • Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases.

    Chien-Liang Glenn Lin;Qiongman Kong;Gregory D Cuny;Gregory D Cuny;Marcie A Glicksman

  • Structure Guided Design of Potent and Selective Ponatinib-Based Hybrid Inhibitors for RIPK1

    Malek Najjar;Chalada Suebsuwong;Soumya S. Ray;Roshan J. Thapa

  • Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

    Jian Xu;Manavi Chatterjee;Tyler D. Baguley;Jonathan Brouillette

Frequent Co-Authors

Lizbeth Hedstrom
Lizbeth Hedstrom Brandeis University
Junying Yuan
Junying Yuan Harvard University
Ross L. Stein
Ross L. Stein Harvard University
Boris Striepen
Boris Striepen University of Pennsylvania
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Alex N. Bullock
Alex N. Bullock University of Oxford
Youngchang Kim
Youngchang Kim Argonne National Laboratory
Kai W. Wucherpfennig
Kai W. Wucherpfennig Harvard University
Christian L. Lorson
Christian L. Lorson University of Missouri
Randall T. Peterson
Randall T. Peterson University of Utah

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