Gregory D. Cuny mainly focuses on Cell biology, Signal transduction, Programmed cell death, Necroptosis and Structure–activity relationship. His Cell biology research is multidisciplinary, incorporating perspectives in BMPR2, Apoptosis and Spindle apparatus, Spindle checkpoint. His work on RIPK1 as part of general Programmed cell death research is frequently linked to Jurkat cells, thereby connecting diverse disciplines of science.
While the research belongs to areas of RIPK1, Gregory D. Cuny spends his time largely on the problem of Ripoptosome, intersecting his research to questions surrounding Autophagy, Cell signaling, Kinase and Death domain. His Necroptosis research includes themes of Necrosis, Pathology and Neuroprotection. His Structure–activity relationship research is multidisciplinary, relying on both Cell culture, Stereochemistry and Enzyme.
His primary scientific interests are in Biochemistry, Cell biology, Kinase, Organic chemistry and Stereochemistry. His biological study spans a wide range of topics, including BMPR2 and Small molecule. His Kinase study incorporates themes from RIPK2 and Phosphorylation.
His studies in Stereochemistry integrate themes in fields like Microsome, Receptor, Chemical synthesis and Alkyl. His research in Structure–activity relationship intersects with topics in Cell culture and Programmed cell death, Necroptosis. His work carried out in the field of Programmed cell death brings together such families of science as Ischemia and Pathology.
Gregory D. Cuny spends much of his time researching Biochemistry, Cell biology, Enzyme, Kinase and Spinal muscular atrophy. In his work, Nucleotide salvage, Purine nucleotide salvage and Purine is strongly intertwined with Cryptosporidium parvum, which is a subfield of Biochemistry. His Cell biology study frequently links to adjacent areas such as Small molecule.
Gregory D. Cuny has researched Enzyme in several fields, including Francisella tularensis and Antibacterial activity. Gregory D. Cuny combines subjects such as RIPK2 and ADME with his study of Kinase. His Cancer research research focuses on Allosteric regulation and how it connects with Signal transduction.
Gregory D. Cuny mainly investigates Biochemistry, Enzyme, Inosine, Dehydrogenase and Mycobacterium tuberculosis. He regularly ties together related areas like Cryptosporidium parvum in his Biochemistry studies. Gregory D. Cuny has included themes like IMP dehydrogenase and Xanthosine in his Enzyme study.
His Inosine research incorporates elements of Benzoxazole, Biosynthesis and Guanine salvage, Guanine, Inosine-5′-monophosphate dehydrogenase.
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Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
Alexei Degterev;Zhihong Huang;Michael Boyce;Yaqiao Li.
Nature Chemical Biology (2005)
Identification of RIP1 kinase as a specific cellular target of necrostatins.
Alexei Degterev;Junichi Hitomi;Megan Germscheid;Irene L Ch'en.
Nature Chemical Biology (2008)
BMP type I receptor inhibition reduces heterotopic ossification
Paul B Yu;Donna Y Deng;Carol S Lai;Charles C Hong.
Nature Medicine (2008)
Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Gregory D. Cuny;Paul B. Yu;Joydev K. Laha;Xuechao Xing.
Bioorganic & Medicinal Chemistry Letters (2008)
Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice
Zerong You;Sean I Savitz;Sean I Savitz;Jinsheng Yang;Alexei Degterev.
Journal of Cerebral Blood Flow and Metabolism (2008)
Pharmacologic Inhibition of the Anaphase-Promoting Complex Induces A Spindle Checkpoint-Dependent Mitotic Arrest in the Absence of Spindle Damage
Xing Zeng;Frederic Sigoillot;Shantanu Gaur;Sungwoon Choi.
Cancer Cell (2010)
Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model.
Daniel M. Rosenbaum;Alexei Degterev;Joel David;Pearl S. Rosenbaum.
Journal of Neuroscience Research (2009)
Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line
Yichin Liu;Yichin Liu;Hilal A. Lashuel;Hilal A. Lashuel;Sungwoon Choi;Xuechao Xing.
Chemistry & Biology (2003)
Structure-activity relationship study of novel necroptosis inhibitors.
Xin Teng;Alexei Degterev;Prakash Jagtap;Xuechao Xing.
Bioorganic & Medicinal Chemistry Letters (2005)
A Mild, One‐Pot Stadler–Ziegler Synthesis of Arylsulfides Facilitated by Photoredox Catalysis in Batch and Continuous‐Flow
Xiao Wang;Gregory D. Cuny;Gregory D. Cuny;Timothy Noël.
Angewandte Chemie (2013)
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