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Chemistry

D-Index
41
Citations
11203
World Ranking
17657
National Ranking
4308

Overview

Ross L. Stein is affiliated with Harvard University in the United States and primarily conducts research in the field of Biochemistry, Genetics, and Molecular Biology. Their scholarly work spans subfields such as Molecular Biology, Infectious Diseases, History and Philosophy of Science, Neurology, and Endocrinology.

The scientist's research topics focus on RNA modifications and cancer, RNA research and splicing, philosophy and history of science, COVID-19 clinical research studies, SARS-CoV-2 and COVID-19 research, long-term effects of COVID-19, and Escherichia coli research studies.

Stein has contributed to multiple publications across reputable scientific venues. Frequent publication venues include:

  • Biochemistry
  • Scientific Reports
  • Molecular Cancer Therapeutics
  • History & Philosophy of the Life Sciences
  • Cancer Research

Recent papers authored by Ross L. Stein include:

  • Kinetic Studies of the Activation of Bordetella pertussis Adenylate Cyclase by Calmodulin, 2022, Biochemistry
  • Mechanisms of macromolecular reactions, 2022, History & Philosophy of the Life Sciences
  • Kinetic and Mechanistic Studies of the Terminal Uridylyltransferase, Zcchc11 (TUT4), 2022, Biochemistry

Other notable papers coauthored or linked to research in related fields include:

  • SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication, 2023, Scientific Reports
  • Targeting the Synthetic Lethal Relationship between FOCAD and TUT7 Represents a Potential Therapeutic Opportunity for TUT4/7 Small-Molecule Inhibitors in Cancer, 2024, Molecular Cancer Therapeutics

Stein's work often intersects with collaborators. Frequent co-authors involved in multiple publications are:

  • Robinson Triboulet
  • Khikmet Sadykov
  • Darren M. Harvey
  • Christopher B. Mayo
  • Dillon Hawley

The patterns in Stein's research illustrate an integration of biochemical processes with broader biological and medical implications. This includes both mechanistic studies at the molecular level and clinical investigations related to infectious diseases and cancer biology.

Best Publications

  • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

    Kenneth L. Rock;Colette Gramm;Lisa Rothstein;Karen Clark

  • Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

    Julian Adams;Mark Behnke;Shaowu Chen;Amy A. Cruickshank

  • Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone.

    Lawrence R. Dick;Amy A. Cruikshank;Louis Grenier;Francesco D. Melandri

  • Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

    Richard K. Harrison;Ross L. Stein

  • KINETIC AND MECHANISTIC STUDIES ON THE HYDROLYSIS OF UBIQUITIN C-TERMINAL 7-AMIDO-4-METHYLCOUMARIN BY DEUBIQUITINATING ENZYMES

    Luan C. Dang;Francesco D. Melandri;Ross L. Stein

  • Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin in Cultured Cells

    Lawrence R. Dick;Amy A. Cruikshank;Antonia T. Destree;Louis Grenier

  • Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

    Yichin Liu;Yichin Liu;Hilal A. Lashuel;Hilal A. Lashuel;Sungwoon Choi;Xuechao Xing

  • SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator.

    Han Dai;Lauren Kustigian;David Carney;April W. Case

  • Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion.

    Richard K. Harrison;Ross L. Stein

  • Mechanism of Enzymatic and Nonenzymatic Prolyl Cis-Trans Isomerization

    Ross L. Stein

  • KINETIC CHARACTERIZATION OF THE CHYMOTRYPTIC ACTIVITY OF THE 20S PROTEASOME

    Ross L. Stein;Francesco Melandri;Lawrence Dick

  • New insights into proteasome function: from archaebacteria to drug development

    Alfred L Goldberg;Ross Stein;Julian Adams

  • Structure-activity relationship study of novel tissue transglutaminase inhibitors

    Eric Duval;April Case;Ross L. Stein;Gregory D. Cuny

  • Mechanism of slow-binding inhibition of human leukocyte elastase by trifluoromethyl ketones.

    Ross L. Stein;Anne M. Strimpler;Phillip D. Edwards;Joseph J. Lewis

  • Kinetics of Amyloid β-Protein Degradation Determined by Novel Fluorescence- and Fluorescence Polarization-based Assays

    Malcolm A. Leissring;Alice Lu;Margaret M. Condron;David B. Teplow

  • KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

    Luisa Quinti;Sharadha Dayalan Naidu;Ulrike Träger;Xiqun Chen

  • Mechanistic studies of enzymic and nonenzymic prolyl cis-trans isomerization

    Richard K. Harrison;Ross L. Stein

  • SIRT1 modulation as a novel approach to the treatment of diseases of aging.

    Charles A. Blum;James L. Ellis;Christine Loh;Pui Yee Ng

  • Catalysis by human leukocyte elastase: mechanistic insights into specificity requirements.

    Ross L. Stein;Anne M. Strimpler;Hitoshi Hori;James C. Powers

  • CHAPTER 28. NOVEL INHIBITORS OF THE PROTEASOME AND THEIR THERAPEUTIC USE IN INFLAMMATION

    Julian Adams;Ross Stein

Frequent Co-Authors

Gregory D. Cuny
Gregory D. Cuny University of Houston
Dennis J. Selkoe
Dennis J. Selkoe Brigham and Women's Hospital
Kevin T. Chapman
Kevin T. Chapman MSD (United States)
Richard L. Schowen
Richard L. Schowen University of Kansas
Kai W. Wucherpfennig
Kai W. Wucherpfennig Harvard University
Peter T. Lansbury
Peter T. Lansbury Harvard University
James C. Powers
James C. Powers Georgia Institute of Technology
Hilal A. Lashuel
Hilal A. Lashuel École Polytechnique Fédérale de Lausanne
Alfred L. Goldberg
Alfred L. Goldberg Harvard University
Zhenyu Yue
Zhenyu Yue Icahn School of Medicine at Mount Sinai

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