World's Best Scientists 2026 revealed!
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Biology and Biochemistry
Netherlands
2025

D-Index & Metrics

Immunology

D-Index
116
Citations
47792
World Ranking
379
National Ranking
14

Research.com Recognitions

  • 2025 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2022 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2015 - Royal Netherlands Academy of Arts and Sciences
  • 2013 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Jacques Neefjes is affiliated with Leiden University Medical Center in the Netherlands. Their research spans multiple domains within life sciences, with a primary focus on biochemistry, genetics, and molecular biology, complemented by contributions to medicine and immunology and microbiology.

Their subfields of study include molecular biology, immunology, oncology, cell biology, and physiology. The main scientific topics of their work cover immune cell function and interaction, immunotherapy and immune responses, cellular transport and secretion, T-cell and B-cell immunology, cancer therapeutics and mechanisms, cancer treatment and pharmacology, as well as calcium signaling and nucleotide metabolism.

Jacques Neefjes has published extensively, with a notable presence in frequent publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, Journal of Cell Science, Molecular Immunology, and iScience.

Recent papers by Neefjes include:

  • New insights into the activities and toxicities of the old anticancer drug doxorubicin, 2020, FEBS Journal
  • Uncoupling DNA damage from chromatin damage to detoxify doxorubicin, 2020, Proceedings of the National Academy of Sciences
  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses, 2020, Immunity
  • Opportunities for Small Molecules in Cancer Immunotherapy, 2020, Trends in Immunology
  • SKIP - HOPS recruits TBC 1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport, 2020, The EMBO Journal

Collaboration has been an important aspect of Neefjes' work, with frequent co-authors including Sabina Y. van der Zanden, Birol Cabukusta, Jimmy J.L.L. Akkermans, Marlieke L.M. Jongsma, and Ilana Berlin. These partnerships have contributed to a substantial and diverse body of research.

Neefjes has received recognition in the scientific community, including being named a member of the Royal Netherlands Academy of Arts and Sciences in 2015, membership in Academia Europaea in 2013, and election to the European Molecular Biology Organization (EMBO).

Best Publications

  • Towards a systems understanding of MHC class I and MHC class II antigen presentation

    Jacques Neefjes;Marlieke L. M. Jongsma;Petra Paul;Oddmund Bakke

  • Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

    Eric A. Reits;James W Hodge;Carla A Herberts;Tom A M Groothuis

  • Empty MHC class I molecules come out in the cold

    H G Ljunggren;N J Stam;C Ohlén;J J Neefjes

  • The Rab7 effector protein RILP controls lysosomal transport by inducing the recruitment of dynein-dynactin motors

    Ingrid Jordens;Mar Fernandez-Borja;Marije Marsman;Simone Dusseljee

  • From fixed to FRAP: measuring protein mobility and activity in living cells.

    Eric A.J. Reits;Jacques J. Neefjes

  • Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments.

    Peter J. Peters;Jacques J. Neefjes;Viola Oorschot;Hidde L. Ploegh

  • Present Yourself! By MHC Class I and MHC Class II Molecules

    Kenneth L. Rock;Eric Reits;Jacques Neefjes;Jacques Neefjes

  • Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning

    Nuno Rocha;Coenraad Kuijl;Rik van der Kant;Lennert Janssen

  • Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase.

    Rob A. Gruters;Jacques J. Neefjes;Matthijs Tersmette;Ruud E. Y. de Goede

  • Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter

    Jacques J. Neefjes;Frank Momburg;Günter J. Hämmerling

  • E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro.

    J. F. M. Leeuwenberg;E. F. Smeets;J. J. Neefjes;M. A. Shaffer

  • Making sense of mass destruction: quantitating MHC class I antigen presentation.

    Jonathan W. Yewdell;Eric Reits;Jacques Neefjes

  • Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin

    Marie Johansson;Nuno Rocha;Wilbert Zwart;Ingrid Jordens

  • The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route.

    Jacques J. Neefjes;Volker Stollorz;Peter J. Peters;Hans J. Geuze

  • Cross-presentation by intercellular peptide transfer through gap junctions

    Joost Neijssen;Carla Herberts;Jan Wouter Drijfhout;Eric Reits

  • The major substrates for TAP in vivo are derived from newly synthesized proteins

    Eric A. J. Reits;Jan C. Vos;Monique Grommé;Jacques Neefjes

  • Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro

    Ton N.M. Schumacher;Marie-Thérèse Heemels;Jacques J. Neefjes;W.Martin Kast

  • MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling.

    Sidong Huang;Michael Hölzel;Theo Knijnenburg;Andreas Schlicker

  • Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin

    Baoxu Pang;Xiaohang Qiao;Lennert Janssen;Arno Velds

  • Mice lacking the MHC class II-associated invariant chain

    Stéphane Viville;Stéphane Viville;Jacques Neefjes;Vincent Lotteau;Andrée Dierich;Andrée Dierich

  • MANNOSE RECEPTOR-MEDIATED UPTAKE OF ANTIGENS STRONGLY ENHANCES HLA CLASS II-RESTRICTED ANTIGEN PRESENTATION BY CULTURED DENDRITIC CELLS

    M. C. A. A. Tan;A. M. Mommaas;J. W. Drijfhout;R. Jordens

Frequent Co-Authors

Hans Janssen
Hans Janssen KU Leuven
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Frank Momburg
Frank Momburg German Cancer Research Center
Jero Calafat
Jero Calafat Antoni van Leeuwenhoek Hospital
Günter J. Hämmerling
Günter J. Hämmerling German Cancer Research Center
Jannie Borst
Jannie Borst Leiden University Medical Center
Thijn R. Brummelkamp
Thijn R. Brummelkamp Antoni van Leeuwenhoek Hospital
Peter A. van Veelen
Peter A. van Veelen Leiden University Medical Center
Jan W. Drijfhout
Jan W. Drijfhout Leiden University Medical Center

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