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Biology and Biochemistry
Netherlands
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
35846
World Ranking
6111
National Ranking
158

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2019 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thijn R. Brummelkamp is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions to Medicine. The scientist's work further specializes in Molecular Biology, Immunology, Oncology, Cell Biology, and Physiology.

The main topics of their research include:

  • Genomics and Chromatin Dynamics
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • RNA Research and Splicing
  • Immunotherapy and Immune Responses
  • Ubiquitin and proteasome pathways
  • PARP inhibition in cancer therapy

Frequent publication venues for their work are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • Nature
  • Nature Communications
  • Immunity

Notable recent publications include:

  • The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses, 2020, Immunity
  • DNA damage induces p53-independent apoptosis through ribosome stalling, 2024, Science
  • Posttranslational modification of microtubules by the MATCAP detyrosinase, 2022, Science
  • The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism, 2022, Nature Structural & Molecular Biology
  • Identification of an alternative triglyceride biosynthesis pathway, 2023, Nature

Collaborative research is a significant component of their work, with frequent coauthors including:

  • Vincent A. Blomen (14 co-publications)
  • Abdelghani Mazouzi (10 co-publications)
  • Matthijs Raaben (8 co-publications)
  • Benjamin D. Rowland (8 co-publications)
  • Anastassis Perrakis (7 co-publications)

Awards conferred upon Thijn R. Brummelkamp encompass membership in notable scientific organizations:

  • Member of Academia Europaea, awarded in 2019
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

    Thijn R. Brummelkamp;René Bernards;Reuven Agami

  • A Genomic and Functional Inventory of Deubiquitinating Enzymes

    Sebastian M.B. Nijman;Mark P.A. Luna-Vargas;Arno Velds;Thijn R. Brummelkamp

  • Stable suppression of tumorigenicity by virus-mediated RNA interference.

    Thijn R Brummelkamp;René Bernards;Reuven Agami

  • Ebola virus entry requires the cholesterol transporter Niemann–Pick C1

    Jan E Carette;Jan E Carette;Matthijs Raaben;Anthony C. Wong;Andrew S. Herbert

  • A large-scale RNAi screen in human cells identifies new components of the p53 pathway

    Katrien Berns;E. Marielle Hijmans;Jasper Mullenders;Thijn R. Brummelkamp

  • Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

    Jonathan B. Johnnidis;Marian H. Harris;Robert T. Wheeler;Sandra Stehling-Sun

  • YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells

    Fernando D. Camargo;Sumita Gokhale;Jonathan B. Johnnidis;Dongdong Fu

  • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

    Thijn R. Brummelkamp;Sebastian M. B. Nijman;Annette M. G. Dirac;René Bernards

  • Yap1 acts downstream of α-catenin to control epidermal proliferation

    Karin Schlegelmilch;Morvarid Mohseni;Morvarid Mohseni;Oktay Kirak;Jan Pruszak;Jan Pruszak

  • Gene essentiality and synthetic lethality in haploid human cells

    Vincent A. Blomen;Peter Májek;Lucas T. Jae;Johannes W. Bigenzahn

  • The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

    Judith H.I. Haarhuis;Robin H. van der Weide;Vincent A. Blomen;J. Omar Yáñez-Cuna

  • The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

    Sebastian M.B. Nijman;Tony T. Huang;Annette M.G. Dirac;Thijn R. Brummelkamp

  • Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

    Marc van de Wetering;Irma Oving;Vanesa Muncan;Menno Tjon Pon Fong

  • Identification of CMTM6 and CMTM4 as PD-L1 protein regulators

    Riccardo Mezzadra;Chong Sun;Lucas T. Jae;Raquel Gomez-Eerland

  • Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

    Jan E. Carette;Carla P. Guimaraes;Malini Varadarajan;Annie S. Park

  • Human Immunodeficiency Virus Type 1 Escapes from RNA Interference-Mediated Inhibition

    Atze T. Das;Thijn R. Brummelkamp;Ellen M. Westerhout;Monique Vink

  • Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

    Katsumori Segawa;Sachiko Kurata;Yuichi Yanagihashi;Thijn R. Brummelkamp

  • Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

    Susanne M.A. Lens;Rob M.F. Wolthuis;Rob Klompmaker;Jos Kauw

  • Ebola virus entry requires the host-programmed recognition of an intracellular receptor

    Emily Happy Miller;Gregor Obernosterer;Matthijs Raaben;Andrew S Herbert

  • Oncogenic BRAF Regulates Melanoma Proliferation through the Lineage Specific Factor MITF

    Claudia Wellbrock;Sareena Rana;Hugh Paterson;Helen Pickersgill

Frequent Co-Authors

Jan E. Carette
Jan E. Carette Stanford University
René Bernards
René Bernards Antoni van Leeuwenhoek Hospital
John M. Dye
John M. Dye United States Army Medical Research Institute of Infectious Diseases
Kartik Chandran
Kartik Chandran Albert Einstein College of Medicine
Reuven Agami
Reuven Agami Antoni van Leeuwenhoek Hospital
Hidde L. Ploegh
Hidde L. Ploegh Boston Children's Hospital
Giulio Superti-Furga
Giulio Superti-Furga Medical University of Vienna
Jacques Neefjes
Jacques Neefjes Leiden University Medical Center
Sean P. J. Whelan
Sean P. J. Whelan Washington University in St. Louis
Sven Rottenberg
Sven Rottenberg University of Bern

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