What is he best known for?
The fields of study he is best known for:
Thijn R. Brummelkamp focuses on Cell biology, Gene, Small interfering RNA, Genetics and Genetic screen.
His research integrates issues of Cell type and YAP1 in his study of Cell biology.
Thijn R. Brummelkamp is involved in the study of Gene that focuses on Ploidy in particular.
The Small interfering RNA study combines topics in areas such as Molecular biology, RNA interference, Downregulation and upregulation and Gene expression.
His work in the fields of Genetics, such as Model organism, Synthetic lethality, Insertional mutagenesis and Cytolethal distending toxin, intersects with other areas such as Diphthamide.
The study incorporates disciplines such as Transmembrane protein, B7-H1 Antigen, PD-L1, Retinoblastoma-like protein 1 and Regulation of gene expression in addition to Genetic screen.
His most cited work include:
- A System for Stable Expression of Short Interfering RNAs in Mammalian Cells (4483 citations)
- A Genomic and Functional Inventory of Deubiquitinating Enzymes (1362 citations)
- Stable suppression of tumorigenicity by virus-mediated RNA interference. (1114 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of study are Cell biology, Genetic screen, Genetics, Gene and Virology.
The concepts of his Cell biology study are interwoven with issues in Transcription factor, DNA and Downregulation and upregulation.
His Genetic screen study incorporates themes from Gene expression, Sterol regulatory element-binding protein, Transmembrane protein, PD-L1 and Regulation of gene expression.
His work deals with themes such as RNA and Gene silencing, which intersect with Gene expression.
His study in Insertional mutagenesis, Small interfering RNA and Mutation is carried out as part of his Gene studies.
In his work, Ebolavirus is strongly intertwined with NPC1, which is a subfield of Virology.
He most often published in these fields:
- Cell biology (46.71%)
- Genetic screen (38.16%)
- Genetics (29.61%)
What were the highlights of his more recent work (between 2018-2021)?
- Cancer research (19.74%)
- T cell (10.53%)
- Signal transduction (18.42%)
In recent papers he was focusing on the following fields of study:
Thijn R. Brummelkamp mainly investigates Cancer research, T cell, Signal transduction, Antigen presentation and Cell biology.
His research investigates the connection with Cancer research and areas like DNA damage which intersect with concerns in Poly ADP ribose polymerase, Polymerase and Homologous recombination.
His Signal transduction research is multidisciplinary, relying on both Cell culture, HAP1 cells, Interferon, Suppressor and Genetic screen.
His Genetic screen research incorporates themes from Gene expression, Sterol regulatory element-binding protein, mTORC1, Lipid metabolism and Gene silencing.
As a part of the same scientific family, Thijn R. Brummelkamp mostly works in the field of Antigen presentation, focusing on Human leukocyte antigen and, on occasion, Autoimmunity, Glycosphingolipid, CD8 and Cell.
Thijn R. Brummelkamp combines subjects such as Cytoskeleton and Gene isoform with his study of Cell biology.
Between 2018 and 2021, his most popular works were:
- Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. (55 citations)
- BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity (35 citations)
- BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity (35 citations)
In his most recent research, the most cited papers focused on:
The scientist’s investigation covers issues in Signal transduction, Interferon, Cancer research, Cell culture and T cell.
Thijn R. Brummelkamp has researched Signal transduction in several fields, including Tumor necrosis factor alpha, Cytokine, NFKB1, Programmed cell death and ASK1.
He interconnects Immune checkpoint, DNA damage, HAP1 cells and Tumor microenvironment in the investigation of issues within T cell.
Many of his studies on Immune checkpoint apply to Cell biology as well.
His Cell biology research is multidisciplinary, incorporating elements of Cancer cell, Antigen, Immunotherapy, Cancer immunotherapy and CD47.
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