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Biology and Biochemistry
Netherlands
2023
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Molecular Biology
Netherlands
2023

D-Index & Metrics

Molecular Biology

D-Index
107
Citations
47111
World Ranking
409
National Ranking
14

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2023 - Research.com Molecular Biology in Netherlands Leader Award
  • 2022 - Research.com Biology and Biochemistry in Netherlands Leader Award
  • 2013 - Royal Netherlands Academy of Arts and Sciences
  • 2012 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

René H. Medema is affiliated with the Antoni van Leeuwenhoek Hospital in the Netherlands. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and cancer-related disciplines including cancer research and oncology.

The scientist's main research topics include:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • Cancer Genomics and Diagnostics
  • Cancer-related Molecular Pathways
  • Epigenetics and DNA Methylation
  • Microtubule and mitosis dynamics

Frequent co-authors with whom René H. Medema has collaborated include:

  • Jonne A. Raaijmakers
  • Lenno Krenning
  • Anoek Friskes
  • Bas van Steensel
  • Roderick L. Beijersbergen

The scientist has published extensively in several research venues. The most frequent publication outlets are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cancer Discovery
  • Cell Reports
  • Radiotherapy and Oncology

Representative recent papers by René H. Medema include:

  • 3D genomics across the tree of life reveals condensin II as a determinant of architecture type, 2021, Science
  • Impact of chromatin context on Cas9-induced DNA double-strand break repair pathway balance, 2021, Molecular Cell
  • Degree and site of chromosomal instability define its oncogenic potential, 2020, Nature Communications
  • Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site, 2020, British Journal of Cancer
  • Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence, 2022, Cancer Discovery

Recognition of René H. Medema's scientific contributions includes membership in prestigious organizations and academies:

  • Royal Netherlands Academy of Arts and Sciences (2013)
  • Member of Academia Europaea (2012)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

    Marc van de Wetering;Elena Sancho;Cornelis Verweij;Wim de Lau

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1.

    René H. Medema;Geert J. P. L. Kops;Johannes L. Bos;Boudewijn M. T. Burgering

  • Cell death by mitotic catastrophe : a molecular definition

    Maria Castedo;Jean-Luc Perfettini;Thomas Roumier;Karine Andreau

  • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

    Pascale F Dijkers;Rene H Medema;Jan-Willem J Lammers;Leo Koenderman

  • FoxM1 is required for execution of the mitotic programme and chromosome stability

    Jamila Laoukili;Matthijs R H Kooistra;Alexandra Brás;Jos Kauw

  • Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

    P.F. Dijkers;R.H. Medema;C. Pals;L. Banerji

  • Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

    Libor Macůrek;Arne Lindqvist;Dan Lim;Michael A. Lampson

  • The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

    Marie Stahl;Pascale F. Dijkers;Geert J. P. L. Kops;Susanne M. A. Lens

  • The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

    Judith H.I. Haarhuis;Robin H. van der Weide;Vincent A. Blomen;J. Omar Yáñez-Cuna

  • The decision to enter mitosis: feedback and redundancy in the mitotic entry network.

    Arne Lindqvist;Verónica Rodríguez-Bravo;René H. Medema

  • Shared and separate functions of polo-like kinases and aurora kinases in cancer

    Susanne M. A. Lens;Emile E. Voest;René H. Medema

  • FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

    Armando van der Horst;Leon G.J. Tertoolen;Lydia M.M. de Vries-Smits;Roy A. Frye

  • Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D

    Marc Schmidt;Sylvia Fernandez de Mattos;Armando van der Horst;Rob Klompmaker

  • Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

    Aniek Janssen;Marja van der Burg;Karoly Szuhai;Geert J. P. L. Kops

  • FoxM1 Promotes β-Catenin Nuclear Localization and Controls Wnt Target-Gene Expression and Glioma Tumorigenesis

    Nu Zhang;Nu Zhang;Ping Wei;Ping Wei;Aihua Gong;Wen Tai Chiu

  • FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

    Andrew Sunters;Silvia Fernández de Mattos;Marie Stahl;Jan J. Brosens

  • Polo-like kinase-1 is a target of the DNA damage checkpoint.

    Veronique A. J. Smits;Rob Klompmaker;Lionel Arnaud;Lionel Arnaud;Gert Rijksen

  • Growth suppression by p16ink4 requires functional retinoblastoma protein

    Rene H. Medema;Rafael E. Herrera;Felix Lam;Robert A. Weinberg

  • Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

    Boudewijn M. T. Burgering;René H. Medema

Frequent Co-Authors

Geert J. P. L. Kops
Geert J. P. L. Kops Royal Netherlands Academy of Arts and Sciences
Boudewijn M. T. Burgering
Boudewijn M. T. Burgering Utrecht University
Susanne M.A. Lens
Susanne M.A. Lens Utrecht University
Johannes L. Bos
Johannes L. Bos Utrecht University
Eric Lam
Eric Lam Sun Yat-sen University
Emile E. Voest
Emile E. Voest Antoni van Leeuwenhoek Hospital
Anastassis Perrakis
Anastassis Perrakis Antoni van Leeuwenhoek Hospital
Anna Akhmanova
Anna Akhmanova Utrecht University
Shabaz Mohammed
Shabaz Mohammed University of Oxford
Paul J. Coffer
Paul J. Coffer Utrecht University

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