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Biology and Biochemistry

D-Index
84
Citations
35248
World Ranking
3252
National Ranking
83

Overview

Paul J. Coffer is affiliated with Utrecht University in the Netherlands and has contributed extensively to research in medicine, immunology, and molecular biology. Their work spans a variety of interrelated fields, including immunology and microbiology, biochemistry, genetics, molecular biology, oncology, biomedical engineering, and hematology.

Their research addresses numerous specialized subfields, such as immunology, oncology, molecular biology, biomedical engineering, and hematology. Key topics examined in their scientific output include immune cell function and interaction, T-cell and B-cell immunology, CAR-T cell therapy research, cancer immunotherapy and biomarkers, immune cells in cancer, cancer cells and metastasis, and 3D printing in biomedical research.

Paul J. Coffer has published articles in several scientific venues, with frequent publications appearing in bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, iScience, Frontiers in Immunology, and Nature Communications.

Notable recent papers authored or co-authored by Paul J. Coffer include:

  • Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting (2022) in Frontiers in Immunology
  • C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition (2020) in Nature Communications
  • Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation (2023) in Cell Reports
  • Regulation of a progenitor gene program by SOX4 is essential for mammary tumor proliferation (2021) in Oncogene
  • Rnd3 Expression is Necessary to Maintain Mitochondrial Homeostasis but Dispensable for Autophagy (2022) in Frontiers in Cell and Developmental Biology

Their frequent co-authors include Enric Mocholí, Michal Mokrý, Sonia Aristín Revilla, Onno Kranenburg, and Cynthia Lisanne Frederiks.

Best Publications

  • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

    Nicholas Arpaia;Clarissa Campbell;Xiying Fan;Stanislav Dikiy

  • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

    Boudewijn M. Th. Burgering;Paul J. Coffer

  • Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

    Geert J. P. L. Kops;Tobias B. Dansen;Paulien E. Polderman;Ingrid Saarloos

  • Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

    Andrea Kauffmann-Zeh;Pablo Rodriguez-Viciana;Eugen Ulrich;Christopher Gilbert

  • Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

    Paul J. Coffer;Jing Jin;James R. Woodgett

  • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

    Pascale F Dijkers;Rene H Medema;Jan-Willem J Lammers;Leo Koenderman

  • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons

    Jonathan Gilley;Paul J. Coffer;Jonathan Ham

  • Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

    P.F. Dijkers;R.H. Medema;C. Pals;L. Banerji

  • Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

    Paul J. Coffer;James R. Woodgett

  • The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

    Marie Stahl;Pascale F. Dijkers;Geert J. P. L. Kops;Susanne M. A. Lens

  • FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

    Andrew Sunters;Silvia Fernández de Mattos;Marie Stahl;Jan J. Brosens

  • Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

    Geert J. P. L. Kops;Rene H. Medema;Janet Glassford;Marieke A. G. Essers

  • Forkhead-box transcription factors and their role in the immune system

    Paul J. Coffer;Boudewijn M. T. Burgering

  • FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B–enhanced cell survival through maintenance of mitochondrial integrity

    Pascale F. Dijkers;Kim U. Birkenkamp;Eric W.-F. Lam;N. Shaun B. Thomas

  • Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

    Kohjiro Ueki;Ritsuko Yamamoto-Honda;Yasushi Kaburagi;Toshimasa Yamauchi

  • Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor

    Dietmar M.W. Zaiss;Jorg van Loosdregt;Andrea Gorlani;Cornelis P.J. Bekker

  • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

    Jorg Van Loosdregt;Yvonne Vercoulen;Teun Guichelaar;Yoony Y J Gent

  • Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy

    Lianne van de Laar;Paul J. Coffer;Paul J. Coffer;Andrea M. Woltman

  • Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes.

    J F Tanti;S Grillo;T Grémeaux;P J Coffer

  • Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors

    KU Birkenkamp;PJ Coffer

Frequent Co-Authors

Leo Koenderman
Leo Koenderman Utrecht University
Michal Mokry
Michal Mokry Utrecht University
Edo Vellenga
Edo Vellenga University Medical Center Groningen
Eric Lam
Eric Lam Sun Yat-sen University
Berent J. Prakken
Berent J. Prakken Utrecht University
Boudewijn M. T. Burgering
Boudewijn M. T. Burgering Utrecht University
Edward E. S. Nieuwenhuis
Edward E. S. Nieuwenhuis Utrecht University
Jan Jacob Schuringa
Jan Jacob Schuringa University Medical Center Groningen
René H. Medema
René H. Medema Princess Máxima Center
Harry L.A. Janssen
Harry L.A. Janssen Erasmus University Rotterdam

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