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Molecular Biology
UK
2026
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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Molecular Biology

D-Index
131
Citations
80439
World Ranking
180
National Ranking
10

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2005 - Fellow of the Royal Society, United Kingdom
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Julian Downward is affiliated with The Francis Crick Institute in the United Kingdom. Their research focuses primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant work published in the subfields of Molecular Biology, Oncology, Immunology, Pulmonary and Respiratory Medicine, and Radiology, Nuclear Medicine and Imaging.

The scientist's recent publication record includes several papers relevant to cancer research and immunology. Notable recent publications include:

  • "Lung adenocarcinoma promotion by air pollutants" (2023, Nature)
  • "Therapeutic KRAS G12C inhibition drives effective interferon-mediated antitumor immunity in immunogenic lung cancers" (2022, Science Advances)
  • "Exploiting the therapeutic implications of KRAS inhibition on tumor immunity" (2024, Cancer Cell)
  • "Hematopoietic aging promotes cancer by fueling IL-1⍺-driven emergency myelopoiesis" (2024, Science)
  • "Drugging the Undruggable: Advances on RAS Targeting in Cancer" (2021, Genes)

Frequent co-authors who have collaborated extensively with Julian Downward include:

  • Míriam Molina-Arcas
  • Charles Swanton
  • Jesse Boumelha
  • Sareena Rana
  • David C. Hancock

The scientist has contributed to numerous research articles published in the following venues with high frequency:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)
  • Molecular Cancer Research

The main research topics addressed in Julian Downward's work cover areas related to cancer biology and immune response mechanisms, such as:

  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Monoclonal and Polyclonal Antibodies Research
  • PI3K/AKT/mTOR signaling in cancer
  • Immune cells in cancer
  • Melanoma and MAPK Pathways
  • RNA modifications and cancer

Julian Downward's recognitions include being named a Fellow of the Royal Society, United Kingdom, in 2005. They are also a Member of the European Molecular Biology Organization (EMBO) and a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

    Marco Gerlinger;Andrew J. Rowan;Stuart Horswell;James Larkin

  • Targeting RAS signalling pathways in cancer therapy

    Julian Downward

  • Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

    A Ullrich;L Coussens;J S Hayflick;T J Dull

  • Close similarity of epidermal growth factor receptor and v- erb-B oncogene protein sequences

    J. Downward;Y. Yarden;E. Mayes;G. Scrace

  • PHOSPHATIDYLINOSITOL-3-OH KINASE AS A DIRECT TARGET OF RAS

    Pablo Rodriguez-Viciana;Patricia H. Warne;Ritu Dhand;Bart Vanhaesebroeck

  • Mechanisms and consequences of activation of protein kinase B/Akt.

    Julian Downward

  • Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

    Andrea Kauffmann-Zeh;Pablo Rodriguez-Viciana;Eugen Ulrich;Christopher Gilbert

  • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

    László Buday;Julian Downward

  • Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

    Pablo Rodriguez-Viciana;Patricia H Warne;Asim Khwaja;Barbara M Marte

  • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

    Asim Khwaja;Pablo Rodriguez‐Viciana;Stefan Wennström;Patricia H. Warne

  • Stimulation of p21ras upon T-cell activation

    Julian Downward;Jonathan D. Graves;Patricia H. Warne;Sydonia Rayter

  • PI 3-kinase, Akt and cell survival.

    Julian Downward

  • Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.

    Subham Basu;Nicholas F Totty;Meredith S Irwin;Marius Sudol

  • Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

    Patricia H. Warne;Pablo Rodrigueza Vician;Julian Downward

  • Autophosphorylation sites on the epidermal growth factor receptor.

    J. Downward;P. Parker;M. D. Waterfield

  • Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways.

    Elzbieta Janda;Kerstin Lehmann;Iris Killisch;Martin Jechlinger

  • PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

    Barbara M. Marte;Julian Downward

  • RAS Interaction with PI3K: More Than Just Another Effector Pathway.

    Esther Castellano;Julian Downward

  • Navigating gene expression using microarrays — a technology review

    Almut Schulze;Julian Downward

  • Expression cloning and characterization of the TGF-β type III receptor

    Xiao-Fan Wang;Herbert Y. Lin;Elinor Ng-Eaton;Julian Downward

Frequent Co-Authors

Charles Swanton
Charles Swanton The Francis Crick Institute
Zoltan Szallasi
Zoltan Szallasi Boston Children's Hospital
Christopher I. Moore
Christopher I. Moore Brown University
Michael Howell
Michael Howell The Francis Crick Institute
Almut Schulze
Almut Schulze German Cancer Research Center
Mike Waterfield
Mike Waterfield Ludwig Cancer Research
Doreen A. Cantrell
Doreen A. Cantrell University of Dundee
Peter J. Parker
Peter J. Parker The Francis Crick Institute
Michael D. Waterfield
Michael D. Waterfield Ludwig Cancer Research
Alexandre Arcaro
Alexandre Arcaro University of Bern

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