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Biology and Biochemistry
UK
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
102
Citations
32895
World Ranking
1390
National Ranking
82

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2025 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2023 - Research.com Biology and Biochemistry in United Kingdom Leader Award
  • 2011 - Fellow of the Royal Society, United Kingdom
  • 2005 - Fellow of the Royal Society of Edinburgh
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Doreen A. Cantrell is affiliated with the University of Dundee in the United Kingdom and has an extensive research profile primarily in the fields of Immunology and Microbiology, Medicine, and Biochemistry, Genetics and Molecular Biology. Their research spans several interconnected domains including Immunology, Molecular Biology, and Oncology, with additional focus on Epidemiology and Infectious Diseases.

The scientist's work covers a variety of topics related to immune function and cellular mechanisms. Key research themes include:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • COVID-19 Clinical Research Studies
  • CAR-T cell therapy research
  • Genomics, phytochemicals, and oxidative stress
  • Immune cells in cancer
  • Sepsis Diagnosis and Treatment

Their recent significant publications reflect studies on T cell biology and immune metabolism, such as:

  • Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation (2020, eLife)
  • Protein synthesis, degradation, and energy metabolism in T cell immunity (2022, Cellular and Molecular Immunology)
  • Mitochondrial translation is required for sustained killing by cytotoxic T cells (2021, Science)
  • Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response (2022, iScience)
  • Single Cell Glucose Uptake Assays: A Cautionary Tale (2020, Immunometabolism)

Cantrell's research is frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), eLife, Nature Immunology, Wellcome Open Research, and Frontiers in Immunology.

Collaborations form an important part of Cantrell's scientific activity. Frequent co-authors include Alejandro J. Brenes, Andrew J.M. Howden, Julia M. Marchingo, Linda V. Sinclair, and Angus I. Lamond.

The scientist has been recognized with several honors, including:

  • Fellow of the Royal Society, United Kingdom (2011)
  • Fellow of the Royal Society of Edinburgh (2005)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • The interleukin-2 T-cell system: a new cell growth model.

    Doreen A. Cantrell;Kendall A. Smith

  • Stimulation of p21ras upon T-cell activation

    Julian Downward;Jonathan D. Graves;Patricia H. Warne;Sydonia Rayter

  • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

    Stephan Sauer;Ludovica Bruno;Arnulf Hertweck;David Finlay

  • T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

    Doreen Cantrell

  • Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

    Linda V Sinclair;Julia Rolf;Elizabeth Emslie;Yun-Bo Shi

  • Transient expression of interleukin 2 receptors. Consequences for T cell growth.

    Doreen A. Cantrell;Kendall A. Smith

  • Phosphoinositide 3-kinase signalling pathways.

    Doreen Ann Cantrell

  • Signaling and Function of Interleukin-2 in T Lymphocytes

    Sarah H Ross;Doreen A Cantrell

  • Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway

    Stefan C. Meuer;Rebecca E. Hussey;Doreen A. Cantrell;James C. Hodgdon

  • PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

    David K. Finlay;Ella Rosenzweig;Linda V. Sinclair;Carmen Feijoo-Carnero

  • Interleukin 2 regulates its own receptors.

    Kendall A. Smith;Doreen A. Cantrell

  • Phosphatidylinositol 3-Kinase Couples the Interleukin-2 Receptor to the Cell Cycle Regulator E2F

    Paul Brennan;Jane W Babbage;Boudewijn M.T Burgering;Bernd Groner

  • Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.

    Linda V Sinclair;David Finlay;Carmen Feijoo;Georgina H Cornish

  • Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes

    Peter Tamás;Simon A. Hawley;Rosemary G. Clarke;Kirsty J. Mustard

  • Protein kinase C and beyond

    Martin Spitaler;Doreen A Cantrell

  • Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes

    Doreen A. Cantrell;Adelina A. Davies;Michael J. Crumpton

  • Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

    Karin Rei;Catherine D. Nobes;George Thomas;Alan Hall

  • Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling.

    Eric Sebzda;Madelon Bracke;Tamara Tugal;Nancy Hogg

  • T Cell Activation and the Cytoskeleton

    Oreste Acuto;Doreen Cantrell

  • T-cell activation.

    Manuel Izquierdo;Doreen A. Cantrell

Frequent Co-Authors

Michael J. Crumpton
Michael J. Crumpton EMF Biological Research Trust
Julian Downward
Julian Downward The Francis Crick Institute
Stephen G. Ward
Stephen G. Ward University of Bath
Enrique Rozengurt
Enrique Rozengurt University of California, Los Angeles
Angus I. Lamond
Angus I. Lamond University of Dundee
Marc Foretz
Marc Foretz Université Paris Cité
Benoit Viollet
Benoit Viollet Institut Cochin
Hergen Spits
Hergen Spits University of Amsterdam
Klaus Okkenhaug
Klaus Okkenhaug University of Cambridge

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