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D-Index & Metrics

Biology and Biochemistry

D-Index
107
Citations
57466
World Ranking
1079
National Ranking
648

Research.com Recognitions

  • 2019 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Jeffrey C. Rathmell is affiliated with Vanderbilt University Medical Center in the United States. Their research primarily spans the intersection of medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. The scientist explores key areas including immunology, molecular biology, cancer research, oncology, and physiology.

Their work extensively covers topics such as immune cell function and interaction, immune cells in cancer, cancer, hypoxia, and metabolism, T-cell and B-cell immunology, cancer immunotherapy and biomarkers, adipokines, inflammation, and metabolic diseases, as well as epigenetics and DNA methylation.

Among their recent publications are the following:

  • Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy, 2020, Molecular Cell
  • Cell-programmed nutrient partitioning in the tumour microenvironment, 2021, Nature
  • Metabolic programming and immune suppression in the tumor microenvironment, 2023, Cancer Cell
  • Immunometabolism: From basic mechanisms to translation, 2020, Immunological Reviews
  • Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer, 2020, Journal of Clinical Investigation

Frequent collaborators include W. Kimryn Rathmell, Matthew Z. Madden, Xiang Ye, Kelsey Voss, and Melissa M. Wolf. These partnerships have contributed to a substantial body of work.

Publication venues where this scientist frequently publishes include bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Cancer Research, Journal of Clinical Investigation, and Blood.

Jeffrey C. Rathmell was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2019.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • A guide to immunometabolism for immunologists

    Luke A. J. O'Neill;Rigel J. Kishton;Jeff Rathmell

  • Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

    Ryan D. Michalek;Valerie A. Gerriets;Sarah R. Jacobs;Andrew N. Macintyre

  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.

    Tullia Lindsten;Andrea J. Ross;Ayala King;Wei Xing Zong

  • The CD28 signaling pathway regulates glucose metabolism.

    Kenneth A Frauwirth;James L Riley;Marian H Harris;Richard V Parry

  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

    Ping Chih Ho;Jessica Dauz Bihuniak;Andrew N. MacIntyre;Matthew Staron

  • Metabolic regulation of T lymphocytes.

    Nancie J MacIver;Ryan D Michalek;Jeffrey C Rathmell

  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function.

    Andrew N. Macintyre;Valerie A. Gerriets;Amanda G. Nichols;Ryan D. Michalek

  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

    Sarah R. Jacobs;Catherine E. Herman;Nancie J. MacIver;Jessica A. Wofford

  • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

    Valerie A. Gerriets;Rigel J. Kishton;Amanda G. Nichols;Andrew N. Macintyre

  • Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

    Jeffrey C. Rathmell;Casey J. Fox;David R. Plas;Peter S. Hammerman

  • Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy.

    Jackie E. Bader;Kelsey Voss;Jeffrey C. Rathmell

  • Cell-programmed nutrient partitioning in the tumour microenvironment

    Bradley I. Reinfeld;Bradley I. Reinfeld;Matthew Z. Madden;Matthew Z. Madden;Melissa M. Wolf;Melissa M. Wolf;Anna Chytil

  • Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism

    Matthew G. Vander Heiden;David R. Plas;Jeffrey C. Rathmell;Casey J. Fox

  • Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking

    Heather L. Wieman;Jessica A. Wofford;Jeffrey C. Rathmell

  • Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease

    Jeffrey C Rathmell;Craig B Thompson

  • Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

    Aaron M. Hosios;Vivian C. Hecht;Laura V. Danai;Marc O. Johnson

  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4 + T cells

    Jeffrey C. Rathmell;Michael P. Cooke;William Y. Ho;Jeff Grein

  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival

    Nancie J. MacIver;Sarah R. Jacobs;Heather L. Wieman;Jessica A. Wofford

  • IL-7 enhances the survival and maintains the size of naive T cells

    Jeffrey C. Rathmell;Evan A. Farkash;Wei Gao;Craig B. Thompson

Frequent Co-Authors

Craig B. Thompson
Craig B. Thompson Memorial Sloan Kettering Cancer Center
Jason W. Locasale
Jason W. Locasale Duke University
W. Kimryn Rathmell
W. Kimryn Rathmell Vanderbilt University Medical Center
Olga Ilkayeva
Olga Ilkayeva Duke University
E. Dale Abel
E. Dale Abel University of California, Los Angeles
Christopher C. Goodnow
Christopher C. Goodnow Garvan Institute of Medical Research
Donald P. McDonnell
Donald P. McDonnell Duke University
Christopher B. Newgard
Christopher B. Newgard Duke University
Morris J. Birnbaum
Morris J. Birnbaum Pfizer (United States)

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