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Jason W. Locasale

Jason W. Locasale

D-Index & Metrics

Biology and Biochemistry

D-Index
95
Citations
45050
World Ranking
1869
National Ranking
1027

Overview

Jason W. Locasale is affiliated with Duke University in the United States. Their research spans multiple fields and subfields predominantly within biochemistry, genetics, molecular biology, and medicine. The focus areas include molecular biology, cancer research, immunology, physiology, and pulmonary and respiratory medicine.

The scientist's work covers several main topics, highlighting a broad engagement with cancer-related metabolism and epigenetics. These topics include:

  • Cancer, Hypoxia, and Metabolism
  • Epigenetics and DNA Methylation
  • Metabolomics and Mass Spectrometry Studies
  • RNA modifications and cancer
  • Diet and metabolism studies
  • Immune cells in cancer
  • Metabolism, Diabetes, and Cancer

Jason W. Locasale has contributed extensively to the literature, with some recent publications as follows:

  • "Metabolomics in cancer research and emerging applications in clinical oncology," 2021, CA A Cancer Journal for Clinicians
  • "Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion," 2020, Nature Immunology
  • "The evolving metabolic landscape of chromatin biology and epigenetics," 2020, Nature Reviews Genetics
  • "Embracing cancer complexity: Hallmarks of systemic disease," 2024, Cell
  • "Transcriptional diversity and bioenergetic shift in human breast cancer metastasis revealed by single-cell RNA sequencing," 2020, Nature Cell Biology

The frequent coauthors with whom Jason W. Locasale has collaborated include Juan Liu, Xiaojing Liu, Ziwei Dai, Navdeep S. Chandel, and Annamarie E. Allen. This collaborative network reflects a focus on interdisciplinary research across cancer biology and metabolism.

The most common publication venues for their work feature high-impact journals and repositories such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • UNC Libraries
  • Nature Communications
  • Nature Metabolism

Through a broad range of scholarly output and collaboration, Jason W. Locasale's scientific contributions address complex questions related to cancer metabolism, epigenetics, immunology, and related physiological processes.

Best Publications

  • The Warburg Effect: How Does it Benefit Cancer Cells?

    Maria V. Liberti;Jason W. Locasale

  • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

    Haoqiang Ying;Alec C. Kimmelman;Costas A. Lyssiotis;Sujun Hua

  • Serine, glycine and one-carbon units: cancer metabolism in full circle

    Jason W. Locasale

  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses.

    Ping Chih Ho;Jessica Dauz Bihuniak;Andrew N. MacIntyre;Matthew Staron

  • Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    Jason W. Locasale;Alexandra R. Grassian;Tamar Melman;Costas A. Lyssiotis

  • Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

    Dimitrios Anastasiou;Dimitrios Anastasiou;George Poulogiannis;George Poulogiannis;John M. Asara;John M. Asara;Matthew B. Boxer

  • Glutamine Metabolism in Cancer: Understanding the Heterogeneity.

    Ahmad A. Cluntun;Michael J. Lukey;Richard A. Cerione;Jason W. Locasale

  • Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

    Matthew G. Vander Heiden;Matthew G. Vander Heiden;Jason W. Locasale;Jason W. Locasale;Kenneth D. Swanson;Hadar Sharfi

  • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

    Valerie A. Gerriets;Rigel J. Kishton;Amanda G. Nichols;Andrew N. Macintyre

  • A roadmap for interpreting 13 C metabolite labeling patterns from cells

    Joerg M. Buescher;Maciek R. Antoniewicz;Laszlo G. Boros;Shawn C Burgess

  • Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism.

    Marc O. Johnson;Marc O. Johnson;Melissa M. Wolf;Matthew Z. Madden;Gabriela Andrejeva

  • Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

    Ng Shyh-Chang;Jason W. Locasale;Jason W. Locasale;Costas A. Lyssiotis;Costas A. Lyssiotis;Yuxiang Zheng

  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

    Samantha J. Mentch;Mahya Mehrmohamadi;Lei Huang;Xiaojing Liu

  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

    Valerie A Gerriets;Rigel J Kishton;Marc O Johnson;Marc O Johnson;Sivan Cohen

  • Dietary methionine influences therapy in mouse cancer models and alters human metabolism

    Xia Gao;Sydney M. Sanderson;Ziwei Dai;Michael A. Reid

  • Metabolic Flux and the Regulation of Mammalian Cell Growth

    Jason W. Locasale;Lewis C. Cantley;Lewis C. Cantley

  • Metabolomics in cancer research and emerging applications in clinical oncology.

    Daniel R. Schmidt;Daniel R. Schmidt;Rutulkumar Patel;David G. Kirsch;Caroline A. Lewis

  • The impact of cellular metabolism on chromatin dynamics and epigenetics.

    Michael A. Reid;Ziwei Dai;Jason W. Locasale

  • Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

    Matthew G. Vander Heiden;Dimitrios Anastasiou;George Poulogiannis;John M. Asara

  • Amplification of phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

    J. Locasale;J. Locasale;Alexandra Grassian;Rameen Beroukhim;Matthew Langer Meyerson

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
John M. Asara
John M. Asara Beth Israel Deaconess Medical Center
Jeffrey C. Rathmell
Jeffrey C. Rathmell Vanderbilt University Medical Center
Atsuo T. Sasaki
Atsuo T. Sasaki University of Cincinnati
Matthew D. Hirschey
Matthew D. Hirschey Duke University
Costas A. Lyssiotis
Costas A. Lyssiotis University of Michigan–Ann Arbor
Jihye Paik
Jihye Paik Cornell University
Gerhard Wagner
Gerhard Wagner Harvard University
Ernst Lengyel
Ernst Lengyel University of Chicago

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